The roles of membrane microdomains (rafts) in T cell activation

Detergent‐resistant membrane microdomains enriched in sphingolipids, cholesterol and glycosylphosphatidylinositol‐anchored proteins play essential roles in T cell receptor (TCR) signaling. These ‘membrane rafts’ accumulate several cytoplasmic lipid‐modified molecules, including Src‐family kinases, c...

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Veröffentlicht in:	Immunological reviews 2003-02, Vol.191 (1), p.148-164
1. Verfasser:	HOREJSI, Vaclav
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cytoskeleton - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Membrane Microdomains - physiology Receptors, Antigen, T-Cell - physiology Signal Transduction - physiology T-Lymphocytes - physiology
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