In vivo and in vitro effects of glucocorticosteroids on arachidonic acid metabolism and monocyte function in nonasthmatic humans

Glucocorticosteroids are used as anti-inflammatory agents in a range of diseases, however, their mechanism of action is unknown. Recently, inhibition of arachidonic acid metabolism has been suggested as one possible mechanism of action. A series of experiments were undertaken in nonasthmatic humans...

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Veröffentlicht in:	The European respiratory journal 1992-06, Vol.5 (6), p.712-716
Hauptverfasser:	Manso, G, Baker, AJ, Taylor, IK, Fuller, RW
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Adult Aerosols Anti-Inflammatory Agents - pharmacology Arachidonic Acid - metabolism Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Budesonide Dexamethasone - pharmacology Double-Blind Method Drug Evaluation Female Glucocorticoids Humans In Vitro Techniques Leukotriene E4 Male Medical sciences Monocytes - drug effects Pharmacology. Drug treatments Prednisolone - pharmacology Pregnenediones - pharmacology SRS-A - analogs & derivatives SRS-A - urine Thromboxanes - metabolism
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