A shuttle vector system for the investigation of immunoglobulin gene hypermutation: Absence of enhanced mutability in intermediate B cell lines

Somatic hypermutation focused to the rearranged V(D)J segment of the immunoglobulin (Ig) loci contributes substantially to antibody gene diversification. However, neither the precise B cell subset subject to hypermutation nor the molecular mechanism(s) involved is known. One model proposes that Ig s...

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