Quantitation of Human Immunodeficiency Virus Provirus and Circulating Virus: Relationship with Immunologic Parameters
Virologic and seroimmunologic parameters were determined in 56 persons infected with human immunodeficiency virus (HIV). The provirus level varied from 10 to 100,000/106 CD4+ lymphocytes, and genomic HIV RNA was detectable in 39 of 56 patients at a relative concentration varying from 10 to >250 c...
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| Veröffentlicht in: | The Journal of infectious diseases 1992-08, Vol.166 (2), p.269-276 |
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| container_title | The Journal of infectious diseases |
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| creator | Yerly, S. Chamot, E. Hirschel, B. Perrin, L. H. |
| description | Virologic and seroimmunologic parameters were determined in 56 persons infected with human immunodeficiency virus (HIV). The provirus level varied from 10 to 100,000/106 CD4+ lymphocytes, and genomic HIV RNA was detectable in 39 of 56 patients at a relative concentration varying from 10 to >250 copies/ml, of serum. Provirus expressed as copies per 106 CD4+ lymphocytes and as circulating virus per milliliter of serum increased with disease progression and decrease of CD4+ cell concentration. The mean provirus concentration expressed per milliliter of blood varied little among categories of patients with various levels of CD4+ cells, but there was a progressive increase of circulating HIV genomic RNA. These virologic data suggest that during the course of HIV infection, an increasing proportion of the remaining CD4+ lymphocytes harbor the HIV genome and produce infectious virus. Finally, there was a marked correlation between increased provirus and genomic RNA concentration and three seroimmunologic markers: decrease in CD4+cell count, p24 antigenemia, and disappearance of antibodies to HIV core antigen. |
| doi_str_mv | 10.1093/infdis/166.2.269 |
| format | Article |
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H.</creator><creatorcontrib>Yerly, S. ; Chamot, E. ; Hirschel, B. ; Perrin, L. H.</creatorcontrib><description>Virologic and seroimmunologic parameters were determined in 56 persons infected with human immunodeficiency virus (HIV). The provirus level varied from 10 to 100,000/106 CD4+ lymphocytes, and genomic HIV RNA was detectable in 39 of 56 patients at a relative concentration varying from 10 to >250 copies/ml, of serum. Provirus expressed as copies per 106 CD4+ lymphocytes and as circulating virus per milliliter of serum increased with disease progression and decrease of CD4+ cell concentration. The mean provirus concentration expressed per milliliter of blood varied little among categories of patients with various levels of CD4+ cells, but there was a progressive increase of circulating HIV genomic RNA. These virologic data suggest that during the course of HIV infection, an increasing proportion of the remaining CD4+ lymphocytes harbor the HIV genome and produce infectious virus. Finally, there was a marked correlation between increased provirus and genomic RNA concentration and three seroimmunologic markers: decrease in CD4+cell count, p24 antigenemia, and disappearance of antibodies to HIV core antigen.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/166.2.269</identifier><identifier>PMID: 1353103</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>AIDS ; AIDS/HIV ; Antibodies ; Base Sequence ; Biological and medical sciences ; Blood ; CD4-Positive T-Lymphocytes - microbiology ; DNA ; DNA, Viral - blood ; Female ; Genomics ; HIV ; HIV Antibodies - blood ; HIV Core Protein p24 - blood ; HIV Infections - immunology ; HIV Infections - microbiology ; HIV-1 - genetics ; HIV-1 - growth & development ; HIV-1 - immunology ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Leukocyte Count ; Lymphocytes ; Major Articles ; Male ; Medical sciences ; Molecular Sequence Data ; Nucleic Acid Probes - chemistry ; Proviruses ; Proviruses - genetics ; Proviruses - growth & development ; Proviruses - immunology ; RNA ; RNA, Viral - blood ; Viruses</subject><ispartof>The Journal of infectious diseases, 1992-08, Vol.166 (2), p.269-276</ispartof><rights>Copyright 1992 The University of Chicago</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3409-5f06a62fbd1e8cd5712705e141c4310290bb633197bcd974e9624762243d59563</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30112924$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30112924$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4412290$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1353103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yerly, S.</creatorcontrib><creatorcontrib>Chamot, E.</creatorcontrib><creatorcontrib>Hirschel, B.</creatorcontrib><creatorcontrib>Perrin, L. H.</creatorcontrib><title>Quantitation of Human Immunodeficiency Virus Provirus and Circulating Virus: Relationship with Immunologic Parameters</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Virologic and seroimmunologic parameters were determined in 56 persons infected with human immunodeficiency virus (HIV). The provirus level varied from 10 to 100,000/106 CD4+ lymphocytes, and genomic HIV RNA was detectable in 39 of 56 patients at a relative concentration varying from 10 to >250 copies/ml, of serum. Provirus expressed as copies per 106 CD4+ lymphocytes and as circulating virus per milliliter of serum increased with disease progression and decrease of CD4+ cell concentration. The mean provirus concentration expressed per milliliter of blood varied little among categories of patients with various levels of CD4+ cells, but there was a progressive increase of circulating HIV genomic RNA. These virologic data suggest that during the course of HIV infection, an increasing proportion of the remaining CD4+ lymphocytes harbor the HIV genome and produce infectious virus. Finally, there was a marked correlation between increased provirus and genomic RNA concentration and three seroimmunologic markers: decrease in CD4+cell count, p24 antigenemia, and disappearance of antibodies to HIV core antigen.</description><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Antibodies</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>CD4-Positive T-Lymphocytes - microbiology</subject><subject>DNA</subject><subject>DNA, Viral - blood</subject><subject>Female</subject><subject>Genomics</subject><subject>HIV</subject><subject>HIV Antibodies - blood</subject><subject>HIV Core Protein p24 - blood</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - microbiology</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - growth & development</subject><subject>HIV-1 - immunology</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Leukocyte Count</subject><subject>Lymphocytes</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Nucleic Acid Probes - chemistry</subject><subject>Proviruses</subject><subject>Proviruses - genetics</subject><subject>Proviruses - growth & development</subject><subject>Proviruses - immunology</subject><subject>RNA</subject><subject>RNA, Viral - blood</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFvFCEUh4nR1HX17sVkDsbbbIHHQPFmN7Zb3cRq1BgvhGGYljoDKwyt_e_FztqeeMn3e194P4ReErwiWMKh833n0iHhfEVXlMtHaEEaEDXnBB6jBcaU1uRIyqfoWUpXGGMGXBygAwINEAwLlD9n7Sc36ckFX4W-2uRR--psHLMPne2dcdab2-q7izlV5zFc3w3ad9XaRZOHsugvZvy2-mKHO1G6dLvqxk2Xe9EQLpypznXUo51sTM_Rk14Pyb7Yv0v07eT91_Wm3n46PVu_29YGGJZ102OuOe3bjtgj0zWCUIEbSxgxrHyfSty2HIBI0ZpOCmYlp0xwShl0jWw4LNGb2buL4Xe2aVKjS8YOg_Y25KQEYAFUQgniOWhiSCnaXu2iG3W8VQSrf02ruWlVmlZUlabLyqu9O7ej7R4W5moLf73nOhk99FF7UwT_Y4wRWg540FylKcR7DJgQKsshS1TP3KXJ_rnnOv5SXIBo1ObHT7VhHz5uj-mpOoG_AuahRQ</recordid><startdate>199208</startdate><enddate>199208</enddate><creator>Yerly, S.</creator><creator>Chamot, E.</creator><creator>Hirschel, B.</creator><creator>Perrin, L. H.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199208</creationdate><title>Quantitation of Human Immunodeficiency Virus Provirus and Circulating Virus: Relationship with Immunologic Parameters</title><author>Yerly, S. ; Chamot, E. ; Hirschel, B. ; Perrin, L. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3409-5f06a62fbd1e8cd5712705e141c4310290bb633197bcd974e9624762243d59563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Antibodies</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>CD4-Positive T-Lymphocytes - microbiology</topic><topic>DNA</topic><topic>DNA, Viral - blood</topic><topic>Female</topic><topic>Genomics</topic><topic>HIV</topic><topic>HIV Antibodies - blood</topic><topic>HIV Core Protein p24 - blood</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - microbiology</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - growth & development</topic><topic>HIV-1 - immunology</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Leukocyte Count</topic><topic>Lymphocytes</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Nucleic Acid Probes - chemistry</topic><topic>Proviruses</topic><topic>Proviruses - genetics</topic><topic>Proviruses - growth & development</topic><topic>Proviruses - immunology</topic><topic>RNA</topic><topic>RNA, Viral - blood</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yerly, S.</creatorcontrib><creatorcontrib>Chamot, E.</creatorcontrib><creatorcontrib>Hirschel, B.</creatorcontrib><creatorcontrib>Perrin, L. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yerly, S.</au><au>Chamot, E.</au><au>Hirschel, B.</au><au>Perrin, L. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitation of Human Immunodeficiency Virus Provirus and Circulating Virus: Relationship with Immunologic Parameters</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1992-08</date><risdate>1992</risdate><volume>166</volume><issue>2</issue><spage>269</spage><epage>276</epage><pages>269-276</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Virologic and seroimmunologic parameters were determined in 56 persons infected with human immunodeficiency virus (HIV). The provirus level varied from 10 to 100,000/106 CD4+ lymphocytes, and genomic HIV RNA was detectable in 39 of 56 patients at a relative concentration varying from 10 to >250 copies/ml, of serum. Provirus expressed as copies per 106 CD4+ lymphocytes and as circulating virus per milliliter of serum increased with disease progression and decrease of CD4+ cell concentration. The mean provirus concentration expressed per milliliter of blood varied little among categories of patients with various levels of CD4+ cells, but there was a progressive increase of circulating HIV genomic RNA. These virologic data suggest that during the course of HIV infection, an increasing proportion of the remaining CD4+ lymphocytes harbor the HIV genome and produce infectious virus. Finally, there was a marked correlation between increased provirus and genomic RNA concentration and three seroimmunologic markers: decrease in CD4+cell count, p24 antigenemia, and disappearance of antibodies to HIV core antigen.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>1353103</pmid><doi>10.1093/infdis/166.2.269</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 1992-08, Vol.166 (2), p.269-276 |
| issn | 0022-1899 1537-6613 |
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| subjects | AIDS AIDS/HIV Antibodies Base Sequence Biological and medical sciences Blood CD4-Positive T-Lymphocytes - microbiology DNA DNA, Viral - blood Female Genomics HIV HIV Antibodies - blood HIV Core Protein p24 - blood HIV Infections - immunology HIV Infections - microbiology HIV-1 - genetics HIV-1 - growth & development HIV-1 - immunology Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Leukocyte Count Lymphocytes Major Articles Male Medical sciences Molecular Sequence Data Nucleic Acid Probes - chemistry Proviruses Proviruses - genetics Proviruses - growth & development Proviruses - immunology RNA RNA, Viral - blood Viruses |
| title | Quantitation of Human Immunodeficiency Virus Provirus and Circulating Virus: Relationship with Immunologic Parameters |
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