Increase in Erythrocyte Disaggregation Shear Stress in Hypertension
The aggregation and disaggregation behaviors of red blood cells were investigated in 17 nonnotensive and 21 hypertensive subjects with a laser reflectometry technique, and simultaneous measurements were taken of blood viscosity with a coaxial viscometer. Increased red blood cell aggregation (26%, p...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1992-08, Vol.20 (2), p.247-252 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Razavian, Seyed Mahmoud del Pino, Muriel Simon, Alain Levenson, Jaime |
| description | The aggregation and disaggregation behaviors of red blood cells were investigated in 17 nonnotensive and 21 hypertensive subjects with a laser reflectometry technique, and simultaneous measurements were taken of blood viscosity with a coaxial viscometer. Increased red blood cell aggregation (26%, p < 0.001) and disaggregation shear rate (20%, p < 0.01) and shear stress (18%, p < 0.01) were observed in hypertensive subjects when compared with nonnotensive subjects. Similar elevations in hypertensive subjects were found when the hematocrit was adjusted to 40%. Variation of red blood cell concentration caused the red blood cell disaggregation shear rate to change in an opposite direction but did not modify red blood cell aggregability and disaggregation shear stress. The increase of the reversible aggregation of red blood cells was associated with higher fibrinogen and plasma protein concentrations in hypertension. An increase in red blood cell aggregability and in the shear resistance of red blood cell aggregates may play a role in the development of the cardiovascular complication in hypertension. The quantification of red blood cell disaggregation shear stress, which represents the hydrodynamic force required to disperse the aggregates, may provide a useful parameter for clinical investigations. |
| doi_str_mv | 10.1161/01.HYP.20.2.247 |
| format | Article |
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Increased red blood cell aggregation (26%, p < 0.001) and disaggregation shear rate (20%, p < 0.01) and shear stress (18%, p < 0.01) were observed in hypertensive subjects when compared with nonnotensive subjects. Similar elevations in hypertensive subjects were found when the hematocrit was adjusted to 40%. Variation of red blood cell concentration caused the red blood cell disaggregation shear rate to change in an opposite direction but did not modify red blood cell aggregability and disaggregation shear stress. The increase of the reversible aggregation of red blood cells was associated with higher fibrinogen and plasma protein concentrations in hypertension. An increase in red blood cell aggregability and in the shear resistance of red blood cell aggregates may play a role in the development of the cardiovascular complication in hypertension. The quantification of red blood cell disaggregation shear stress, which represents the hydrodynamic force required to disperse the aggregates, may provide a useful parameter for clinical investigations.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.20.2.247</identifier><identifier>PMID: 1639467</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Proteins - analysis ; Blood Viscosity ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Erythrocyte Aggregation ; Fibrinogen - analysis ; Hematocrit ; Humans ; Hypertension - blood ; Hypertension - physiopathology ; Kinetics ; Medical sciences ; Reference Values ; Stress, Mechanical</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1992-08, Vol.20 (2), p.247-252</ispartof><rights>1992 American Heart Association, Inc.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4537-4f0479184e5659ea3207c095bdac9fad367faba8dcc3fbdb6af387b4c73fda863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5497702$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1639467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Razavian, Seyed Mahmoud</creatorcontrib><creatorcontrib>del Pino, Muriel</creatorcontrib><creatorcontrib>Simon, Alain</creatorcontrib><creatorcontrib>Levenson, Jaime</creatorcontrib><title>Increase in Erythrocyte Disaggregation Shear Stress in Hypertension</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>The aggregation and disaggregation behaviors of red blood cells were investigated in 17 nonnotensive and 21 hypertensive subjects with a laser reflectometry technique, and simultaneous measurements were taken of blood viscosity with a coaxial viscometer. Increased red blood cell aggregation (26%, p < 0.001) and disaggregation shear rate (20%, p < 0.01) and shear stress (18%, p < 0.01) were observed in hypertensive subjects when compared with nonnotensive subjects. Similar elevations in hypertensive subjects were found when the hematocrit was adjusted to 40%. Variation of red blood cell concentration caused the red blood cell disaggregation shear rate to change in an opposite direction but did not modify red blood cell aggregability and disaggregation shear stress. The increase of the reversible aggregation of red blood cells was associated with higher fibrinogen and plasma protein concentrations in hypertension. An increase in red blood cell aggregability and in the shear resistance of red blood cell aggregates may play a role in the development of the cardiovascular complication in hypertension. The quantification of red blood cell disaggregation shear stress, which represents the hydrodynamic force required to disperse the aggregates, may provide a useful parameter for clinical investigations.</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Proteins - analysis</subject><subject>Blood Viscosity</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Erythrocyte Aggregation</subject><subject>Fibrinogen - analysis</subject><subject>Hematocrit</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - physiopathology</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Reference Values</subject><subject>Stress, Mechanical</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1r3DAQhkVpSTcf554KPpTe7Iw-LFnHskm7gUALaSE5ibE82nXrtbeSl7D_vgq7pANiEO-jF_Ew9oFDxbnm18Cr1dOPSkAlKqHMG7bgtVClqrV8yxbArSot54_v2XlKvwG4UsqcsTOupVXaLNjybvSRMFHRj8VtPMybOPnDTMVNn3C9jrTGuZ_G4mFDGIuHOVJKL-jqsKM405hyeMneBRwSXZ32Bfv19fbnclXef_92t_xyX3pVS1OqAMpY3iiqdW0JpQDjwdZth94G7KQ2AVtsOu9laLtWY5CNaZU3MnTYaHnBPh97d3H6u6c0u22fPA0DjjTtkzMSjNANZPD6CPo4pRQpuF3stxgPjoN70eaAu6zNCXDCZW35xcdT9b7dUvefP3rK-adTjsnjECKOvk-vWK2sMSAypo7Y8zTMFNOfYf9M0WV3w7xxkEflD5bcWgFNvpX5cCP_ARmlhYs</recordid><startdate>199208</startdate><enddate>199208</enddate><creator>Razavian, Seyed Mahmoud</creator><creator>del Pino, Muriel</creator><creator>Simon, Alain</creator><creator>Levenson, Jaime</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199208</creationdate><title>Increase in Erythrocyte Disaggregation Shear Stress in Hypertension</title><author>Razavian, Seyed Mahmoud ; del Pino, Muriel ; Simon, Alain ; Levenson, Jaime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4537-4f0479184e5659ea3207c095bdac9fad367faba8dcc3fbdb6af387b4c73fda863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Proteins - analysis</topic><topic>Blood Viscosity</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Erythrocyte Aggregation</topic><topic>Fibrinogen - analysis</topic><topic>Hematocrit</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - physiopathology</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Reference Values</topic><topic>Stress, Mechanical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Razavian, Seyed Mahmoud</creatorcontrib><creatorcontrib>del Pino, Muriel</creatorcontrib><creatorcontrib>Simon, Alain</creatorcontrib><creatorcontrib>Levenson, Jaime</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Razavian, Seyed Mahmoud</au><au>del Pino, Muriel</au><au>Simon, Alain</au><au>Levenson, Jaime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase in Erythrocyte Disaggregation Shear Stress in Hypertension</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1992-08</date><risdate>1992</risdate><volume>20</volume><issue>2</issue><spage>247</spage><epage>252</epage><pages>247-252</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>The aggregation and disaggregation behaviors of red blood cells were investigated in 17 nonnotensive and 21 hypertensive subjects with a laser reflectometry technique, and simultaneous measurements were taken of blood viscosity with a coaxial viscometer. Increased red blood cell aggregation (26%, p < 0.001) and disaggregation shear rate (20%, p < 0.01) and shear stress (18%, p < 0.01) were observed in hypertensive subjects when compared with nonnotensive subjects. Similar elevations in hypertensive subjects were found when the hematocrit was adjusted to 40%. Variation of red blood cell concentration caused the red blood cell disaggregation shear rate to change in an opposite direction but did not modify red blood cell aggregability and disaggregation shear stress. The increase of the reversible aggregation of red blood cells was associated with higher fibrinogen and plasma protein concentrations in hypertension. An increase in red blood cell aggregability and in the shear resistance of red blood cell aggregates may play a role in the development of the cardiovascular complication in hypertension. The quantification of red blood cell disaggregation shear stress, which represents the hydrodynamic force required to disperse the aggregates, may provide a useful parameter for clinical investigations.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>1639467</pmid><doi>10.1161/01.HYP.20.2.247</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 1992-08, Vol.20 (2), p.247-252 |
| issn | 0194-911X 1524-4563 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Proteins - analysis Blood Viscosity Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Erythrocyte Aggregation Fibrinogen - analysis Hematocrit Humans Hypertension - blood Hypertension - physiopathology Kinetics Medical sciences Reference Values Stress, Mechanical |
| title | Increase in Erythrocyte Disaggregation Shear Stress in Hypertension |
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