High-resolution crystal structure of Trypanosoma brucei UDP-galactose 4′-epimerase: a potential target for structure-based development of novel trypanocides

The crystal structure of UDP-galactose 4′-epimerase from the protozoan parasite Trypanosoma brucei in complex with the cofactor NAD + and a fragment of the substrates, UDP, has been determined at 2.0 Å resolution ( 1 A ̊ =0.1 nm). This enzyme, recently proven to be essential for this pathogenic para...

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