Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor

Background & Aims: Factors associated with the development and malignant progression of Barrett's esophagus are poorly understood. Gastrin is a mitogen capable of inducing growth in normal and malignant gastrointestinal mucosa. It is unknown whether gastrin can influence cellular events in...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2003-03, Vol.124 (3), p.615-625
Hauptverfasser:	Haigh, Chris R., Attwood, Stephen E.A., Thompson, David G., Jankowski, Janusz A., Kirton, Chris M., Pritchard, D.Mark, Varro, Andrea, Dimaline, Rod
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Autoradiography Barrett Esophagus - metabolism Barrett Esophagus - pathology Binding, Competitive Biological and medical sciences Blotting, Northern Cell Division - drug effects Cell Division - physiology Computer Systems Esophagus Female Gastric Mucosa - pathology Gastrins - metabolism Gastrins - pharmacokinetics Gastrins - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Humans Iodine Radioisotopes Male Medical sciences Metaplasia Middle Aged Other diseases. Semiology Radioimmunoassay Receptor, Cholecystokinin B Receptors, Cholecystokinin - metabolism Reverse Transcriptase Polymerase Chain Reaction Thymidine - metabolism Tumor Cells, Cultured
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