Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants

Camptothecin derivatives are clinically used anti-neoplastic alkaloids that biogenetically belong to monoterpenoid indole alkaloids. Camptothecin-related alkaloids from the methanol extracts of Ophiorrhiza pumila, Camptotheca acuminata and Nothapodytes foetida plants were profiled and identified usi...

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Veröffentlicht in:	Phytochemistry (Oxford) 2003-02, Vol.62 (3), p.461-470
Hauptverfasser:	Yamazaki, Yasuyo, Urano, Akiko, Sudo, Hiroshi, Kitajima, Mariko, Takayama, Hiromitsu, Yamazaki, Mami, Aimi, Norio, Saito, Kazuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinone Anthraquinones - chemistry Anthraquinones - isolation & purification Anti-tumor alkaloid Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - metabolism Biological and medical sciences Camptotheca acuminata Camptothecin Camptothecin - analogs & derivatives Camptothecin - biosynthesis Carbon-Nitrogen Lyases - metabolism Chemical constitution Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Icacinaceae Indole Alkaloids - chemistry Indole Alkaloids - isolation & purification Indole Alkaloids - metabolism Nothapodytes foetida Nyssaceae Ophiorrhiza pumila Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Leaves - chemistry Plant Leaves - enzymology Plant physiology and development Plant Roots - chemistry Plant Roots - enzymology Plant Stems - chemistry Plant Stems - enzymology Plants, Medicinal - metabolism RNA, Messenger - biosynthesis Rubiaceae Sesquiterpenes Spectrometry, Mass, Electrospray Ionization Strictosidine synthase (STR) Terpenes Tissue Distribution
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