Effect of Treatment of Anaemia with Erythropoietin on Neuromuscular Function in Patients on Long Term Haemodialysis
To study the effect of treatment of anaemia with recombinant human erythropoietin (r-HUEPO) on neuromuscular function in patients undergoing haemodialysis for chronic renal failure, six patients were given r-HUEPO in an initial dose of 50 u/kg three times a week and their haemoglobin concentration w...
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| Veröffentlicht in: | Scandinavian journal of urology and nephrology 1992, Vol.26 (1), p.65-69 |
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| container_title | Scandinavian journal of urology and nephrology |
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| creator | Sobh, Mohamed A. El-Tantawy, Abd El-Halim Said, Ehab Atta, Mohamed Gehad Refaie, Ayman Nagati, Mohamed Ghoneim, Mohamed |
| description | To study the effect of treatment of anaemia with recombinant human erythropoietin (r-HUEPO) on neuromuscular function in patients undergoing haemodialysis for chronic renal failure, six patients were given r-HUEPO in an initial dose of 50 u/kg three times a week and their haemoglobin concentration was measured. The dose was increased by 25 u/kg every four weeks if the response was not satisfactory. In five patients anaemia had been corrected within 12 weeks of initiation of treatment. Neuromuscular function was evaluated before treatment, half way through, and after correction of anaemia by clinical examination and neurophysiological studies including motor nerve conduction velocity, distal latency, electromyography and test for neuromuscular fatigue. After correction of anaemia there was a significant increase in motor nerve conduction velocity, a decrease in the duration of motor unit action potential, and a lessening of neuromuscular fatigue. We conclude that treatment of anaemia with r-HUEPO in patients with chronic renal failure undergoing haemodialysis may improve neuromuscular function. |
| doi_str_mv | 10.3109/00365599209180398 |
| format | Article |
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The dose was increased by 25 u/kg every four weeks if the response was not satisfactory. In five patients anaemia had been corrected within 12 weeks of initiation of treatment. Neuromuscular function was evaluated before treatment, half way through, and after correction of anaemia by clinical examination and neurophysiological studies including motor nerve conduction velocity, distal latency, electromyography and test for neuromuscular fatigue. After correction of anaemia there was a significant increase in motor nerve conduction velocity, a decrease in the duration of motor unit action potential, and a lessening of neuromuscular fatigue. We conclude that treatment of anaemia with r-HUEPO in patients with chronic renal failure undergoing haemodialysis may improve neuromuscular function.</description><identifier>ISSN: 0036-5599</identifier><identifier>EISSN: 1651-2065</identifier><identifier>DOI: 10.3109/00365599209180398</identifier><identifier>PMID: 1631509</identifier><identifier>CODEN: SJUNAS</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Adult ; anaemia ; Anemia - drug therapy ; Anemia - etiology ; Biological and medical sciences ; dialysis ; Electromyography ; erythropoietin ; Erythropoietin - pharmacology ; Erythropoietin - therapeutic use ; Hormones. Endocrine system ; Humans ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Middle Aged ; Motor Neurons - drug effects ; Muscle Contraction - drug effects ; Muscles - drug effects ; Muscles - physiopathology ; Neural Conduction - drug effects ; neuromuscular ; Neuromuscular Diseases - drug therapy ; Neuromuscular Diseases - etiology ; Pharmacology. Drug treatments ; Recombinant Proteins - pharmacology ; Recombinant Proteins - therapeutic use ; Renal Dialysis - adverse effects ; Uremia - etiology</subject><ispartof>Scandinavian journal of urology and nephrology, 1992, Vol.26 (1), p.65-69</ispartof><rights>1992 Informa UK Ltd 1992</rights><rights>1992 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-e452a6446aa3b5af94f04ebcb2dcdbec039b3997bd2239971aea5a1cd5f92e93</citedby><cites>FETCH-LOGICAL-c345t-e452a6446aa3b5af94f04ebcb2dcdbec039b3997bd2239971aea5a1cd5f92e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365599209180398$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365599209180398$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5405850$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1631509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sobh, Mohamed A.</creatorcontrib><creatorcontrib>El-Tantawy, Abd El-Halim</creatorcontrib><creatorcontrib>Said, Ehab</creatorcontrib><creatorcontrib>Atta, Mohamed Gehad</creatorcontrib><creatorcontrib>Refaie, Ayman</creatorcontrib><creatorcontrib>Nagati, Mohamed</creatorcontrib><creatorcontrib>Ghoneim, Mohamed</creatorcontrib><title>Effect of Treatment of Anaemia with Erythropoietin on Neuromuscular Function in Patients on Long Term Haemodialysis</title><title>Scandinavian journal of urology and nephrology</title><addtitle>Scand J Urol Nephrol</addtitle><description>To study the effect of treatment of anaemia with recombinant human erythropoietin (r-HUEPO) on neuromuscular function in patients undergoing haemodialysis for chronic renal failure, six patients were given r-HUEPO in an initial dose of 50 u/kg three times a week and their haemoglobin concentration was measured. The dose was increased by 25 u/kg every four weeks if the response was not satisfactory. In five patients anaemia had been corrected within 12 weeks of initiation of treatment. Neuromuscular function was evaluated before treatment, half way through, and after correction of anaemia by clinical examination and neurophysiological studies including motor nerve conduction velocity, distal latency, electromyography and test for neuromuscular fatigue. After correction of anaemia there was a significant increase in motor nerve conduction velocity, a decrease in the duration of motor unit action potential, and a lessening of neuromuscular fatigue. We conclude that treatment of anaemia with r-HUEPO in patients with chronic renal failure undergoing haemodialysis may improve neuromuscular function.</description><subject>Adult</subject><subject>anaemia</subject><subject>Anemia - drug therapy</subject><subject>Anemia - etiology</subject><subject>Biological and medical sciences</subject><subject>dialysis</subject><subject>Electromyography</subject><subject>erythropoietin</subject><subject>Erythropoietin - pharmacology</subject><subject>Erythropoietin - therapeutic use</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor Neurons - drug effects</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscles - drug effects</subject><subject>Muscles - physiopathology</subject><subject>Neural Conduction - drug effects</subject><subject>neuromuscular</subject><subject>Neuromuscular Diseases - drug therapy</subject><subject>Neuromuscular Diseases - etiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Renal Dialysis - adverse effects</subject><subject>Uremia - etiology</subject><issn>0036-5599</issn><issn>1651-2065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFvEzEQhS0EKiHwAzgg7QFx22Kv104suFRVSpEi4JD7atY7Jq68drC9qvLv6yWBCiH1NLLf955mHiFvGb3kjKqPlHIphFINVWxNuVo_IwsmBasbKsVzspj1egZeklcp3VFKG8nkBblgkjNB1YKkjTGocxVMtYsIeUT_-3HlAUcL1b3N-2oTj3kfwyFYzNZXwVffcIphnJKeHMTqZvI62_JdxB-QbclIM7UN_me1wzhWtyUtDBbcMdn0mrww4BK-Oc8l2d1sdte39fb7l6_XV9ta81bkGlvRgGxbCcB7AUa1hrbY674Z9NCjLvf2XKlVPzTNPBkgCGB6EEY1qPiSfDjFHmL4NWHK3WiTRufAY5hSt-JUqlXxLgk7gTqGlCKa7hDtCPHYMdrNPXf_9Vw8787hUz_i8Og4FVv092cdkgZnInht019MtFSsBS3Y5xNmvQlxhPsQ3dBlOLoQ_3j4U1t8-se-R3B5ryFidxem6Eu7T9zwABAerHU</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Sobh, Mohamed A.</creator><creator>El-Tantawy, Abd El-Halim</creator><creator>Said, Ehab</creator><creator>Atta, Mohamed Gehad</creator><creator>Refaie, Ayman</creator><creator>Nagati, Mohamed</creator><creator>Ghoneim, Mohamed</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Effect of Treatment of Anaemia with Erythropoietin on Neuromuscular Function in Patients on Long Term Haemodialysis</title><author>Sobh, Mohamed A. ; El-Tantawy, Abd El-Halim ; Said, Ehab ; Atta, Mohamed Gehad ; Refaie, Ayman ; Nagati, Mohamed ; Ghoneim, Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-e452a6446aa3b5af94f04ebcb2dcdbec039b3997bd2239971aea5a1cd5f92e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>anaemia</topic><topic>Anemia - drug therapy</topic><topic>Anemia - etiology</topic><topic>Biological and medical sciences</topic><topic>dialysis</topic><topic>Electromyography</topic><topic>erythropoietin</topic><topic>Erythropoietin - pharmacology</topic><topic>Erythropoietin - therapeutic use</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor Neurons - drug effects</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscles - drug effects</topic><topic>Muscles - physiopathology</topic><topic>Neural Conduction - drug effects</topic><topic>neuromuscular</topic><topic>Neuromuscular Diseases - drug therapy</topic><topic>Neuromuscular Diseases - etiology</topic><topic>Pharmacology. 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| ispartof | Scandinavian journal of urology and nephrology, 1992, Vol.26 (1), p.65-69 |
| issn | 0036-5599 1651-2065 |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adult anaemia Anemia - drug therapy Anemia - etiology Biological and medical sciences dialysis Electromyography erythropoietin Erythropoietin - pharmacology Erythropoietin - therapeutic use Hormones. Endocrine system Humans Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged Motor Neurons - drug effects Muscle Contraction - drug effects Muscles - drug effects Muscles - physiopathology Neural Conduction - drug effects neuromuscular Neuromuscular Diseases - drug therapy Neuromuscular Diseases - etiology Pharmacology. Drug treatments Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Renal Dialysis - adverse effects Uremia - etiology |
| title | Effect of Treatment of Anaemia with Erythropoietin on Neuromuscular Function in Patients on Long Term Haemodialysis |
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