Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas

To investigate whether GnRH agonists or danazol therapy normalizes estrogen metabolism in the eutopic endometrium of women with endometriosis, adenomyosis, or leiomyomas. Prospective clinical study. University hospital. Fifty-three women with endometriosis, adenomyosis, or leiomyomas. Patients recei...

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Veröffentlicht in:	Fertility and sterility 2003-03, Vol.79, p.735-742
Hauptverfasser:	Ishihara, Hiroaki, Kitawaki, J.o, Kado, Noriko, Koshiba, Hisato, Fushiki, Shinji, Honjo, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomyosis Adult Antineoplastic Agents, Hormonal - pharmacology Aromatase - biosynthesis Aromatase - genetics Aromatase - metabolism aromatase cytochrome P450 Biological and medical sciences Buserelin - pharmacology danazol Danazol - pharmacology endometriosis Endometriosis - drug therapy Endometriosis - enzymology Endometriosis - metabolism endometrium Estrogen Antagonists - pharmacology Estrogens - metabolism Female Genital system. Reproduction GnRH agonists Gonadotropin-Releasing Hormone - agonists Humans In Vitro Techniques Ki-67 Antigen - metabolism Leiomyoma - drug therapy Leiomyoma - enzymology Leiomyoma - metabolism leiomyomas Leuprolide - pharmacology Medical sciences Middle Aged Pharmacology. Drug treatments Prospective Studies Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism RNA, Neoplasm - chemistry RNA, Neoplasm - genetics steroid receptors Uterine Diseases - drug therapy Uterine Diseases - enzymology Uterine Diseases - metabolism Uterine Neoplasms - drug therapy Uterine Neoplasms - enzymology Uterine Neoplasms - metabolism
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