Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder
We previously demonstrated that apolipoprotein D (apoD) levels are elevated in the dorsolateral prefrontal cortex and caudate obtained postmortem from subjects with schizophrenia and bipolar disorder compared to controls, suggesting a focal compensatory response to neuropathology associated with psy...
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| Veröffentlicht in: | Molecular psychiatry 2003-02, Vol.8 (2), p.167-175 |
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| creator | Thomas, E A Dean, B Scarr, E Copolov, D Sutcliffe, J G |
| description | We previously demonstrated that apolipoprotein D (apoD) levels are elevated in the dorsolateral prefrontal cortex and caudate obtained postmortem from subjects with schizophrenia and bipolar disorder compared to controls, suggesting a focal compensatory response to neuropathology associated with psychiatric disorders. We have now extended those studies by measuring apoD protein levels in additional brain regions from post-mortem samples of schizophrenic and bipolar disorder subjects using an enzyme-linked immunosorbent assay. Increased apoD levels were observed in the lateral prefrontal cortex (Brodmann Area 46) in both schizophrenia (46%) and bipolar disorder (111%), and in the orbitofrontal cortex (Brodmann Area 11) (44.3 and 37.9% for schizophrenia and bipolar disorder, respectively). However, differences between the disease groups were observed in other brain regions. In subjects with schizophrenia, but not bipolar disorder, apoD levels were significantly elevated in the amygdala (42.8%) and thalamus (31.7%), while in bipolar disorder, but not schizophrenia, additional increases were detected in the parietal cortex (Brodmann Area 40; 123%) and the cingulate cortex (Brodmann Area 24; 57.7%). These data demonstrate that there is anatomical overlap in the pathophysiologies of schizophrenia and bipolar disorder, as well as areas of pathology that distinguish the two disorders. |
| doi_str_mv | 10.1038/sj.mp.4001223 |
| format | Article |
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We have now extended those studies by measuring apoD protein levels in additional brain regions from post-mortem samples of schizophrenic and bipolar disorder subjects using an enzyme-linked immunosorbent assay. Increased apoD levels were observed in the lateral prefrontal cortex (Brodmann Area 46) in both schizophrenia (46%) and bipolar disorder (111%), and in the orbitofrontal cortex (Brodmann Area 11) (44.3 and 37.9% for schizophrenia and bipolar disorder, respectively). However, differences between the disease groups were observed in other brain regions. In subjects with schizophrenia, but not bipolar disorder, apoD levels were significantly elevated in the amygdala (42.8%) and thalamus (31.7%), while in bipolar disorder, but not schizophrenia, additional increases were detected in the parietal cortex (Brodmann Area 40; 123%) and the cingulate cortex (Brodmann Area 24; 57.7%). These data demonstrate that there is anatomical overlap in the pathophysiologies of schizophrenia and bipolar disorder, as well as areas of pathology that distinguish the two disorders.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/sj.mp.4001223</identifier><identifier>PMID: 12610649</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Adult and adolescent clinical studies ; Amygdala ; Amygdala - metabolism ; Amygdala - pathology ; Anatomy ; Apolipoproteins ; Autopsy ; Behavioral Sciences ; Biological and medical sciences ; Biological Psychology ; Bipolar disorder ; Bipolar Disorder - metabolism ; Bipolar Disorder - pathology ; Bipolar disorders ; Brain ; Brain - metabolism ; Brain - pathology ; Brain architecture ; Brain research ; Brodmann's area ; Cortex (cingulate) ; Cortex (parietal) ; Diagnosis, Differential ; Disease ; Enzyme-linked immunosorbent assay ; Female ; Gyrus Cinguli - metabolism ; Gyrus Cinguli - pathology ; Humans ; immediate-communication ; Ligands ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Mental disorders ; Middle Aged ; Molecular biology ; Mood disorders ; Neurosciences ; Parietal Lobe - metabolism ; Parietal Lobe - pathology ; Pathology ; Pharmacotherapy ; Physiology ; Prefrontal cortex ; Prefrontal Cortex - metabolism ; Prefrontal Cortex - pathology ; Proteins ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Research centers ; Schizophrenia ; Schizophrenia - metabolism ; Schizophrenia - pathology ; T-Box Domain Proteins - metabolism ; Thalamus ; Thalamus - metabolism ; Thalamus - pathology ; Tropical medicine ; Xenopus Proteins</subject><ispartof>Molecular psychiatry, 2003-02, Vol.8 (2), p.167-175</ispartof><rights>Springer Nature Limited 2003</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group 2003</rights><rights>Nature Publishing Group 2003.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-83bcf434f0a90aad6dd79e21ae5e6371d397902aa45f4a1b73f21a455a9735b93</citedby><cites>FETCH-LOGICAL-c513t-83bcf434f0a90aad6dd79e21ae5e6371d397902aa45f4a1b73f21a455a9735b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.mp.4001223$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.mp.4001223$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14568077$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12610649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomas, E A</creatorcontrib><creatorcontrib>Dean, B</creatorcontrib><creatorcontrib>Scarr, E</creatorcontrib><creatorcontrib>Copolov, D</creatorcontrib><creatorcontrib>Sutcliffe, J G</creatorcontrib><title>Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>We previously demonstrated that apolipoprotein D (apoD) levels are elevated in the dorsolateral prefrontal cortex and caudate obtained postmortem from subjects with schizophrenia and bipolar disorder compared to controls, suggesting a focal compensatory response to neuropathology associated with psychiatric disorders. We have now extended those studies by measuring apoD protein levels in additional brain regions from post-mortem samples of schizophrenic and bipolar disorder subjects using an enzyme-linked immunosorbent assay. Increased apoD levels were observed in the lateral prefrontal cortex (Brodmann Area 46) in both schizophrenia (46%) and bipolar disorder (111%), and in the orbitofrontal cortex (Brodmann Area 11) (44.3 and 37.9% for schizophrenia and bipolar disorder, respectively). However, differences between the disease groups were observed in other brain regions. In subjects with schizophrenia, but not bipolar disorder, apoD levels were significantly elevated in the amygdala (42.8%) and thalamus (31.7%), while in bipolar disorder, but not schizophrenia, additional increases were detected in the parietal cortex (Brodmann Area 40; 123%) and the cingulate cortex (Brodmann Area 24; 57.7%). These data demonstrate that there is anatomical overlap in the pathophysiologies of schizophrenia and bipolar disorder, as well as areas of pathology that distinguish the two disorders.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Amygdala</subject><subject>Amygdala - metabolism</subject><subject>Amygdala - pathology</subject><subject>Anatomy</subject><subject>Apolipoproteins</subject><subject>Autopsy</subject><subject>Behavioral Sciences</subject><subject>Biological and medical sciences</subject><subject>Biological Psychology</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - metabolism</subject><subject>Bipolar Disorder - pathology</subject><subject>Bipolar disorders</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain architecture</subject><subject>Brain research</subject><subject>Brodmann's area</subject><subject>Cortex (cingulate)</subject><subject>Cortex (parietal)</subject><subject>Diagnosis, Differential</subject><subject>Disease</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Gyrus Cinguli - pathology</subject><subject>Humans</subject><subject>immediate-communication</subject><subject>Ligands</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Molecular biology</subject><subject>Mood disorders</subject><subject>Neurosciences</subject><subject>Parietal Lobe - metabolism</subject><subject>Parietal Lobe - pathology</subject><subject>Pathology</subject><subject>Pharmacotherapy</subject><subject>Physiology</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Prefrontal Cortex - pathology</subject><subject>Proteins</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Research centers</topic><topic>Schizophrenia</topic><topic>Schizophrenia - metabolism</topic><topic>Schizophrenia - pathology</topic><topic>T-Box Domain Proteins - metabolism</topic><topic>Thalamus</topic><topic>Thalamus - metabolism</topic><topic>Thalamus - pathology</topic><topic>Tropical medicine</topic><topic>Xenopus Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomas, E A</creatorcontrib><creatorcontrib>Dean, B</creatorcontrib><creatorcontrib>Scarr, E</creatorcontrib><creatorcontrib>Copolov, D</creatorcontrib><creatorcontrib>Sutcliffe, J G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomas, E A</au><au>Dean, B</au><au>Scarr, E</au><au>Copolov, D</au><au>Sutcliffe, J G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>8</volume><issue>2</issue><spage>167</spage><epage>175</epage><pages>167-175</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>We previously demonstrated that apolipoprotein D (apoD) levels are elevated in the dorsolateral prefrontal cortex and caudate obtained postmortem from subjects with schizophrenia and bipolar disorder compared to controls, suggesting a focal compensatory response to neuropathology associated with psychiatric disorders. We have now extended those studies by measuring apoD protein levels in additional brain regions from post-mortem samples of schizophrenic and bipolar disorder subjects using an enzyme-linked immunosorbent assay. Increased apoD levels were observed in the lateral prefrontal cortex (Brodmann Area 46) in both schizophrenia (46%) and bipolar disorder (111%), and in the orbitofrontal cortex (Brodmann Area 11) (44.3 and 37.9% for schizophrenia and bipolar disorder, respectively). However, differences between the disease groups were observed in other brain regions. In subjects with schizophrenia, but not bipolar disorder, apoD levels were significantly elevated in the amygdala (42.8%) and thalamus (31.7%), while in bipolar disorder, but not schizophrenia, additional increases were detected in the parietal cortex (Brodmann Area 40; 123%) and the cingulate cortex (Brodmann Area 24; 57.7%). These data demonstrate that there is anatomical overlap in the pathophysiologies of schizophrenia and bipolar disorder, as well as areas of pathology that distinguish the two disorders.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>12610649</pmid><doi>10.1038/sj.mp.4001223</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Amygdala Amygdala - metabolism Amygdala - pathology Anatomy Apolipoproteins Autopsy Behavioral Sciences Biological and medical sciences Biological Psychology Bipolar disorder Bipolar Disorder - metabolism Bipolar Disorder - pathology Bipolar disorders Brain Brain - metabolism Brain - pathology Brain architecture Brain research Brodmann's area Cortex (cingulate) Cortex (parietal) Diagnosis, Differential Disease Enzyme-linked immunosorbent assay Female Gyrus Cinguli - metabolism Gyrus Cinguli - pathology Humans immediate-communication Ligands Male Medical sciences Medicine Medicine & Public Health Mental disorders Middle Aged Molecular biology Mood disorders Neurosciences Parietal Lobe - metabolism Parietal Lobe - pathology Pathology Pharmacotherapy Physiology Prefrontal cortex Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Proteins Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Research centers Schizophrenia Schizophrenia - metabolism Schizophrenia - pathology T-Box Domain Proteins - metabolism Thalamus Thalamus - metabolism Thalamus - pathology Tropical medicine Xenopus Proteins |
| title | Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder |
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