Leucocyte adhesion protein deficiency in Irish setter dogs

Investigation of 12 Irish setter puppies from six litters with severe recurrent infections, neutrophilia and low body weight revealed a leucocyte adhesion protein deficiency with a total lack of CD11b and CD18. Their neutrophil function was severely impaired with a totally absent capacity to ingest...

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Veröffentlicht in:	Veterinary immunology and immunopathology 1992-05, Vol.32 (3), p.261-280
Hauptverfasser:	Trowald-Wigh, Gunilla, Håkansson, Lena, Johannisson, Anders, Norrgren, Leif, Hård af Segerstad, Carl
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Biological and medical sciences Bone Marrow - immunology CD11 Antigens CD18 Antigens Cell Adhesion Chemotaxis Dog Diseases - immunology Dogs Experimental and animal immunopathology. Animal models Female Flow Cytometry Immunologic Deficiency Syndromes - blood Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - veterinary Immunopathology Luminescent Measurements Male Medical sciences Microscopy, Electron, Scanning Neutrophils - immunology Neutrophils - ultrastructure Nitroblue Tetrazolium Phagocytosis Receptors, Leukocyte-Adhesion - genetics
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