Leucocyte adhesion protein deficiency in Irish setter dogs
Investigation of 12 Irish setter puppies from six litters with severe recurrent infections, neutrophilia and low body weight revealed a leucocyte adhesion protein deficiency with a total lack of CD11b and CD18. Their neutrophil function was severely impaired with a totally absent capacity to ingest...
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| Veröffentlicht in: | Veterinary immunology and immunopathology 1992-05, Vol.32 (3), p.261-280 |
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| container_title | Veterinary immunology and immunopathology |
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| creator | Trowald-Wigh, Gunilla Håkansson, Lena Johannisson, Anders Norrgren, Leif Hård af Segerstad, Carl |
| description | Investigation of 12 Irish setter puppies from six litters with severe recurrent infections, neutrophilia and low body weight revealed a leucocyte adhesion protein deficiency with a total lack of CD11b and CD18. Their neutrophil function was severely impaired with a totally absent capacity to ingest C3b-opsonized particles, a significantly impaired capacity to ingest IgG-opsonized particles and significantly diminished adherence to nylon wool when compared with neutrophils from healthy control dogs. The chemiluminescence of patient neutrophils activated by C3b-opsonized particles was, consequently, significantly decreased compared with that of control neutrophils, while the respiratory burst assayed by phorbolmyristate acid (PMA) stimulated nitroblue tetrazolium (NBT)-reduction was normal in the patient group. Random migration and chemotactic responses of patient and control neutrophils, were similar.
The etiology, pathogenesis and clinical manifestations of the Irish setter leucocyte adhesion deficiency were similar to that of the leucocyte adhesion deficiency in humans. |
| doi_str_mv | 10.1016/0165-2427(92)90050-Z |
| format | Article |
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The etiology, pathogenesis and clinical manifestations of the Irish setter leucocyte adhesion deficiency were similar to that of the leucocyte adhesion deficiency in humans.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/0165-2427(92)90050-Z</identifier><identifier>PMID: 1352926</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Antigens, CD - genetics ; Biological and medical sciences ; Bone Marrow - immunology ; CD11 Antigens ; CD18 Antigens ; Cell Adhesion ; Chemotaxis ; Dog Diseases - immunology ; Dogs ; Experimental and animal immunopathology. Animal models ; Female ; Flow Cytometry ; Immunologic Deficiency Syndromes - blood ; Immunologic Deficiency Syndromes - genetics ; Immunologic Deficiency Syndromes - veterinary ; Immunopathology ; Luminescent Measurements ; Male ; Medical sciences ; Microscopy, Electron, Scanning ; Neutrophils - immunology ; Neutrophils - ultrastructure ; Nitroblue Tetrazolium ; Phagocytosis ; Receptors, Leukocyte-Adhesion - genetics</subject><ispartof>Veterinary immunology and immunopathology, 1992-05, Vol.32 (3), p.261-280</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-97cb2f3014f04d3bb9081210ea4e71666bfbc194e28f2a0e84fcda593c80a28d3</citedby><cites>FETCH-LOGICAL-c332t-97cb2f3014f04d3bb9081210ea4e71666bfbc194e28f2a0e84fcda593c80a28d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016524279290050Z$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4519881$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1352926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trowald-Wigh, Gunilla</creatorcontrib><creatorcontrib>Håkansson, Lena</creatorcontrib><creatorcontrib>Johannisson, Anders</creatorcontrib><creatorcontrib>Norrgren, Leif</creatorcontrib><creatorcontrib>Hård af Segerstad, Carl</creatorcontrib><title>Leucocyte adhesion protein deficiency in Irish setter dogs</title><title>Veterinary immunology and immunopathology</title><addtitle>Vet Immunol Immunopathol</addtitle><description>Investigation of 12 Irish setter puppies from six litters with severe recurrent infections, neutrophilia and low body weight revealed a leucocyte adhesion protein deficiency with a total lack of CD11b and CD18. Their neutrophil function was severely impaired with a totally absent capacity to ingest C3b-opsonized particles, a significantly impaired capacity to ingest IgG-opsonized particles and significantly diminished adherence to nylon wool when compared with neutrophils from healthy control dogs. The chemiluminescence of patient neutrophils activated by C3b-opsonized particles was, consequently, significantly decreased compared with that of control neutrophils, while the respiratory burst assayed by phorbolmyristate acid (PMA) stimulated nitroblue tetrazolium (NBT)-reduction was normal in the patient group. Random migration and chemotactic responses of patient and control neutrophils, were similar.
The etiology, pathogenesis and clinical manifestations of the Irish setter leucocyte adhesion deficiency were similar to that of the leucocyte adhesion deficiency in humans.</description><subject>Animals</subject><subject>Antigens, CD - genetics</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - immunology</subject><subject>CD11 Antigens</subject><subject>CD18 Antigens</subject><subject>Cell Adhesion</subject><subject>Chemotaxis</subject><subject>Dog Diseases - immunology</subject><subject>Dogs</subject><subject>Experimental and animal immunopathology. Animal models</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Immunologic Deficiency Syndromes - blood</subject><subject>Immunologic Deficiency Syndromes - genetics</subject><subject>Immunologic Deficiency Syndromes - veterinary</subject><subject>Immunopathology</subject><subject>Luminescent Measurements</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - ultrastructure</subject><subject>Nitroblue Tetrazolium</subject><subject>Phagocytosis</subject><subject>Receptors, Leukocyte-Adhesion - genetics</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEQgIMotVb_gcIeRPSwmtfuJh4EKT4KBS966SVkk4mNtLuabIX-e9MH9aaHYRjmm2HmQ-iU4GuCSXmTosgpp9WlpFcS4wLnkz3UJ6JiOS0Y30f9HXKIjmL8wAmSQvRQj7CCSlr20e0YFqY1yw4ybacQfdtkn6HtwDeZBeeNh8Yss1SNgo_TLELXQchs-x6P0YHTswgn2zxAb48Pr8PnfPzyNBrej3PDGO1yWZmaOoYJd5hbVtcSC0IJBs2hImVZ1q42RHKgwlGNQXBnrC4kMwJrKiwboIvN3nTX1wJip-Y-GpjNdAPtIqqK4VLg9PV_ICkp51jyBPINaEIbYwCnPoOf67BUBKuVW7USp1bilKRq7VZN0tjZdv-inoP9HdrITP3zbV9Ho2cu6Mb4uMN4QZJ8krC7DQZJ2reHoOLaMlgfwHTKtv7vO34A4hyUWA</recordid><startdate>199205</startdate><enddate>199205</enddate><creator>Trowald-Wigh, Gunilla</creator><creator>Håkansson, Lena</creator><creator>Johannisson, Anders</creator><creator>Norrgren, Leif</creator><creator>Hård af Segerstad, Carl</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199205</creationdate><title>Leucocyte adhesion protein deficiency in Irish setter dogs</title><author>Trowald-Wigh, Gunilla ; Håkansson, Lena ; Johannisson, Anders ; Norrgren, Leif ; Hård af Segerstad, Carl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-97cb2f3014f04d3bb9081210ea4e71666bfbc194e28f2a0e84fcda593c80a28d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Antigens, CD - genetics</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - immunology</topic><topic>CD11 Antigens</topic><topic>CD18 Antigens</topic><topic>Cell Adhesion</topic><topic>Chemotaxis</topic><topic>Dog Diseases - immunology</topic><topic>Dogs</topic><topic>Experimental and animal immunopathology. Animal models</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Immunologic Deficiency Syndromes - blood</topic><topic>Immunologic Deficiency Syndromes - genetics</topic><topic>Immunologic Deficiency Syndromes - veterinary</topic><topic>Immunopathology</topic><topic>Luminescent Measurements</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - ultrastructure</topic><topic>Nitroblue Tetrazolium</topic><topic>Phagocytosis</topic><topic>Receptors, Leukocyte-Adhesion - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trowald-Wigh, Gunilla</creatorcontrib><creatorcontrib>Håkansson, Lena</creatorcontrib><creatorcontrib>Johannisson, Anders</creatorcontrib><creatorcontrib>Norrgren, Leif</creatorcontrib><creatorcontrib>Hård af Segerstad, Carl</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trowald-Wigh, Gunilla</au><au>Håkansson, Lena</au><au>Johannisson, Anders</au><au>Norrgren, Leif</au><au>Hård af Segerstad, Carl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leucocyte adhesion protein deficiency in Irish setter dogs</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>1992-05</date><risdate>1992</risdate><volume>32</volume><issue>3</issue><spage>261</spage><epage>280</epage><pages>261-280</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>Investigation of 12 Irish setter puppies from six litters with severe recurrent infections, neutrophilia and low body weight revealed a leucocyte adhesion protein deficiency with a total lack of CD11b and CD18. Their neutrophil function was severely impaired with a totally absent capacity to ingest C3b-opsonized particles, a significantly impaired capacity to ingest IgG-opsonized particles and significantly diminished adherence to nylon wool when compared with neutrophils from healthy control dogs. The chemiluminescence of patient neutrophils activated by C3b-opsonized particles was, consequently, significantly decreased compared with that of control neutrophils, while the respiratory burst assayed by phorbolmyristate acid (PMA) stimulated nitroblue tetrazolium (NBT)-reduction was normal in the patient group. Random migration and chemotactic responses of patient and control neutrophils, were similar.
The etiology, pathogenesis and clinical manifestations of the Irish setter leucocyte adhesion deficiency were similar to that of the leucocyte adhesion deficiency in humans.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1352926</pmid><doi>10.1016/0165-2427(92)90050-Z</doi><tpages>20</tpages></addata></record> |
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| ispartof | Veterinary immunology and immunopathology, 1992-05, Vol.32 (3), p.261-280 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antigens, CD - genetics Biological and medical sciences Bone Marrow - immunology CD11 Antigens CD18 Antigens Cell Adhesion Chemotaxis Dog Diseases - immunology Dogs Experimental and animal immunopathology. Animal models Female Flow Cytometry Immunologic Deficiency Syndromes - blood Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - veterinary Immunopathology Luminescent Measurements Male Medical sciences Microscopy, Electron, Scanning Neutrophils - immunology Neutrophils - ultrastructure Nitroblue Tetrazolium Phagocytosis Receptors, Leukocyte-Adhesion - genetics |
| title | Leucocyte adhesion protein deficiency in Irish setter dogs |
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