Clinical application of hematopoietic progenitor cell expansion: current status and future prospects
In the past decade, we have witnessed significant advances in ex vivo hematopoietic stem cell culture expansion, progressing to the point where clinical trials are being designed and conducted. Preclinical milestone investigations provided data to enable expansion of portions of hematopoietic grafts...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2003-02, Vol.31 (4), p.241-252 |
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| creator | Devine, S M Lazarus, H M Emerson, S G |
| description | In the past decade, we have witnessed significant advances in
ex vivo
hematopoietic stem cell culture expansion, progressing to the point where clinical trials are being designed and conducted. Preclinical milestone investigations provided data to enable expansion of portions of hematopoietic grafts in a clinical setting, indicating safety and feasibility of this approach. Data derived from current clinical trials indicate successful reconstitution of hematopoiesis after myeloablative chemoradiotherapy using infusion of
ex vivo
-expanded perfusion cultures. Future avenues of exploration will focus upon refining preclinical and clinical studies in which cocktails of available cytokines, novel molecules and sophisticated expansion systems will explore expansion of blood, marrow and umbilical cord blood cells. |
| doi_str_mv | 10.1038/sj.bmt.1703813 |
| format | Article |
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ex vivo
hematopoietic stem cell culture expansion, progressing to the point where clinical trials are being designed and conducted. Preclinical milestone investigations provided data to enable expansion of portions of hematopoietic grafts in a clinical setting, indicating safety and feasibility of this approach. Data derived from current clinical trials indicate successful reconstitution of hematopoiesis after myeloablative chemoradiotherapy using infusion of
ex vivo
-expanded perfusion cultures. Future avenues of exploration will focus upon refining preclinical and clinical studies in which cocktails of available cytokines, novel molecules and sophisticated expansion systems will explore expansion of blood, marrow and umbilical cord blood cells.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1703813</identifier><identifier>PMID: 12621458</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood cells ; Bone marrow ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Cell Biology ; Cell culture ; Cell Culture Techniques - methods ; Chemoradiotherapy ; Clinical trials ; Cord blood ; Cytokines ; Hematology ; Hematopoiesis ; Hematopoietic Stem Cell Mobilization - methods ; Hematopoietic Stem Cell Mobilization - trends ; Hematopoietic stem cells ; Hematopoietic Stem Cells - cytology ; Humans ; Internal Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; mini-review ; Perfusion ; Progenitor cells ; Public Health ; Stem cell transplantation ; Stem Cell Transplantation - methods ; Stem Cell Transplantation - trends ; Stem Cells ; Tissue Donors ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Umbilical cord</subject><ispartof>Bone marrow transplantation (Basingstoke), 2003-02, Vol.31 (4), p.241-252</ispartof><rights>Springer Nature Limited 2003</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2, 2003</rights><rights>Nature Publishing Group 2003.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-40af37cff2cbf07d9cfa023f663b3a35f87b095fca88f4f050936f4b11104bbb3</citedby><cites>FETCH-LOGICAL-c554t-40af37cff2cbf07d9cfa023f663b3a35f87b095fca88f4f050936f4b11104bbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.bmt.1703813$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.bmt.1703813$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14637928$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12621458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Devine, S M</creatorcontrib><creatorcontrib>Lazarus, H M</creatorcontrib><creatorcontrib>Emerson, S G</creatorcontrib><title>Clinical application of hematopoietic progenitor cell expansion: current status and future prospects</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>In the past decade, we have witnessed significant advances in
ex vivo
hematopoietic stem cell culture expansion, progressing to the point where clinical trials are being designed and conducted. Preclinical milestone investigations provided data to enable expansion of portions of hematopoietic grafts in a clinical setting, indicating safety and feasibility of this approach. Data derived from current clinical trials indicate successful reconstitution of hematopoiesis after myeloablative chemoradiotherapy using infusion of
ex vivo
-expanded perfusion cultures. Future avenues of exploration will focus upon refining preclinical and clinical studies in which cocktails of available cytokines, novel molecules and sophisticated expansion systems will explore expansion of blood, marrow and umbilical cord blood cells.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood cells</subject><subject>Bone marrow</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cell Biology</subject><subject>Cell culture</subject><subject>Cell Culture Techniques - methods</subject><subject>Chemoradiotherapy</subject><subject>Clinical trials</subject><subject>Cord blood</subject><subject>Cytokines</subject><subject>Hematology</subject><subject>Hematopoiesis</subject><subject>Hematopoietic Stem Cell Mobilization - methods</subject><subject>Hematopoietic Stem Cell Mobilization - trends</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>mini-review</subject><subject>Perfusion</subject><subject>Progenitor cells</subject><subject>Public Health</subject><subject>Stem cell transplantation</subject><subject>Stem Cell Transplantation - methods</subject><subject>Stem Cell Transplantation - trends</subject><subject>Stem Cells</subject><subject>Tissue Donors</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Transplantation</subject><subject>Umbilical cord</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kstv1DAQxi0EokvhyhFZIHrLdhw_knCrVrykSlzgbDlee9erxA62I5X_HkeNtAW18sGv3zczHn8IvSWwJUDb63Ta9mPekqZsCH2GNoQ1ouJU8OdoA7VoK0pFd4FepXQCIIwBf4kuSC1qwni7Qfvd4LzTasBqmoayyC54HCw-mlHlMAVnstN4iuFgvMshYm2GAZu7SflU0E9YzzEan3HKKs8JK7_Hds5zNIsoTUbn9Bq9sGpI5s06X6JfXz7_3H2rbn98_b67ua005yxXDJSljba21r2FZt9pq6CmVgjaU0W5bZseOm61alvLLHDoqLCsJ4QA6_ueXqKr-7gl8-_ZpCxHl5Z6lTdhTrKhIBpOoYAf_gNPYY6-1CZrwWoiAGhTqPdPUqQU1VF4EOqgBiOdtyFHpZe88oa0NaMcWlao7SNUGXszOh28sa6c_yO4eiA4GjXkYwrDvHxPejSyLt1O0Vg5RTeq-EcSkItFZDrJYhG5WqQI3q2vmvvR7M_46okCfFwBlYoxbFReu3TmmKBNVy_c9T2XypU_mHhuzxOp_wICKtMJ</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Devine, S M</creator><creator>Lazarus, H M</creator><creator>Emerson, S G</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Clinical application of hematopoietic progenitor cell expansion: current status and future prospects</title><author>Devine, S M ; Lazarus, H M ; Emerson, S G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-40af37cff2cbf07d9cfa023f663b3a35f87b095fca88f4f050936f4b11104bbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood cells</topic><topic>Bone marrow</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Cell Biology</topic><topic>Cell culture</topic><topic>Cell Culture Techniques - methods</topic><topic>Chemoradiotherapy</topic><topic>Clinical trials</topic><topic>Cord blood</topic><topic>Cytokines</topic><topic>Hematology</topic><topic>Hematopoiesis</topic><topic>Hematopoietic Stem Cell Mobilization - methods</topic><topic>Hematopoietic Stem Cell Mobilization - trends</topic><topic>Hematopoietic stem cells</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>mini-review</topic><topic>Perfusion</topic><topic>Progenitor cells</topic><topic>Public Health</topic><topic>Stem cell transplantation</topic><topic>Stem Cell Transplantation - methods</topic><topic>Stem Cell Transplantation - trends</topic><topic>Stem Cells</topic><topic>Tissue Donors</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Transplantation</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devine, S M</creatorcontrib><creatorcontrib>Lazarus, H M</creatorcontrib><creatorcontrib>Emerson, S G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devine, S M</au><au>Lazarus, H M</au><au>Emerson, S G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical application of hematopoietic progenitor cell expansion: current status and future prospects</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>31</volume><issue>4</issue><spage>241</spage><epage>252</epage><pages>241-252</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><coden>BMTRE9</coden><abstract>In the past decade, we have witnessed significant advances in
ex vivo
hematopoietic stem cell culture expansion, progressing to the point where clinical trials are being designed and conducted. Preclinical milestone investigations provided data to enable expansion of portions of hematopoietic grafts in a clinical setting, indicating safety and feasibility of this approach. Data derived from current clinical trials indicate successful reconstitution of hematopoiesis after myeloablative chemoradiotherapy using infusion of
ex vivo
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| ispartof | Bone marrow transplantation (Basingstoke), 2003-02, Vol.31 (4), p.241-252 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood cells Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Cell Biology Cell culture Cell Culture Techniques - methods Chemoradiotherapy Clinical trials Cord blood Cytokines Hematology Hematopoiesis Hematopoietic Stem Cell Mobilization - methods Hematopoietic Stem Cell Mobilization - trends Hematopoietic stem cells Hematopoietic Stem Cells - cytology Humans Internal Medicine Medical sciences Medicine Medicine & Public Health mini-review Perfusion Progenitor cells Public Health Stem cell transplantation Stem Cell Transplantation - methods Stem Cell Transplantation - trends Stem Cells Tissue Donors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Umbilical cord |
| title | Clinical application of hematopoietic progenitor cell expansion: current status and future prospects |
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