Hypoxia produces cell death in the rat hippocampus in the presence of an A1 adenosine receptor antagonist : an anatomical and behavioral study
Endogenous adenosine depresses synaptic transmission in rat hippocampal slices during periods of hypoxia, a potentially neuroprotective cellular response that is attenuated by the adenosine antagonist 8-cyclopentyltheophylline. In this study, rats were exposed to moderate hypoxic conditions (5% O2-...
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| Veröffentlicht in: | Neuroscience 1992-06, Vol.48 (4), p.807-812 |
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| creator | BOISSARD, C. G LINDNER, M. D GRIBKOFF, V. K |
| description | Endogenous adenosine depresses synaptic transmission in rat hippocampal slices during periods of hypoxia, a potentially neuroprotective cellular response that is attenuated by the adenosine antagonist 8-cyclopentyltheophylline. In this study, rats were exposed to moderate hypoxic conditions (5% O2- 95% N2, 40 min x three days) in the presence or absence of 8-cyclopentyltheophylline, and the effects of reducing adenosinergic inhibition during hypoxia were assessed histologically and behaviorally. Half the rats exposed to low levels of oxygen in the presence of 8-cyclopentyltheophylline (10 mg/kg) suffered unilateral or bilateral hippocampal damage largely limited to the CA1 subfield. Animals which had suffered hippocampal damage were also impaired in their performance of a working memory version of the Morris Water Maze, but not a passive avoidance task (step-through). Hypoxia alone did not result in neuronal damage or behavioral impairment. These results provide further evidence that endogenous adenosine provides an important level of neuronal protection during even prolonged periods of hypoxia. |
| doi_str_mv | 10.1016/0306-4522(92)90268-7 |
| format | Article |
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G</creatorcontrib><creatorcontrib>LINDNER, M. D</creatorcontrib><creatorcontrib>GRIBKOFF, V. K</creatorcontrib><title>Hypoxia produces cell death in the rat hippocampus in the presence of an A1 adenosine receptor antagonist : an anatomical and behavioral study</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Endogenous adenosine depresses synaptic transmission in rat hippocampal slices during periods of hypoxia, a potentially neuroprotective cellular response that is attenuated by the adenosine antagonist 8-cyclopentyltheophylline. In this study, rats were exposed to moderate hypoxic conditions (5% O2- 95% N2, 40 min x three days) in the presence or absence of 8-cyclopentyltheophylline, and the effects of reducing adenosinergic inhibition during hypoxia were assessed histologically and behaviorally. Half the rats exposed to low levels of oxygen in the presence of 8-cyclopentyltheophylline (10 mg/kg) suffered unilateral or bilateral hippocampal damage largely limited to the CA1 subfield. Animals which had suffered hippocampal damage were also impaired in their performance of a working memory version of the Morris Water Maze, but not a passive avoidance task (step-through). Hypoxia alone did not result in neuronal damage or behavioral impairment. These results provide further evidence that endogenous adenosine provides an important level of neuronal protection during even prolonged periods of hypoxia.</description><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Death - drug effects</subject><subject>Central nervous system</subject><subject>Cognition - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - pathology</subject><subject>Hippocampus - physiopathology</subject><subject>Hypoxia - pathology</subject><subject>Hypoxia - physiopathology</subject><subject>Male</subject><subject>Memory - drug effects</subject><subject>Motor Activity - drug effects</subject><subject>Purinergic Antagonists</subject><subject>Pyramidal Tracts - drug effects</subject><subject>Pyramidal Tracts - pathology</subject><subject>Pyramidal Tracts - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Reference Values</subject><subject>Theophylline - analogs & derivatives</subject><subject>Theophylline - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUduKFDEQDaKs4-gfKORBRB9ac-2Lb8uirrDgy7431UnFiUwnbZIW5yf8ZtPMuBaBqso5p6BOEfKSs_ec8fYDk6xtlBbi7SDeDUy0fdM9Ijved7LptFKPye6B8pQ8y_kHq6GVvCJXvK2IaHfkz-1pib890CVFuxrM1ODxSC1COVAfaDkgTVDowS9LNDAva_73vSTMGAzS6CgEes0pWAwx-1AlaHApMVWgwPcYfC7048aCACXO3sCxlpZOeIBfPqba5rLa03PyxMEx44tL3pP7z5_ub26bu29fvt5c3zVGqLY0rbYaLMheaFSm49C1ALL2k3O9MKLvOu4mq-SEXCN3_STYMHGr3SAHhXJP3pzH1q1_rpjLOPu8LQ4B45rHrrrTaj1UojoTTYo5J3TjkvwM6TRyNm5XGDeLx83icahvu0JV78mry_x1mtH-F51tr_jrCw65WuESBOPzA01LqRVn8i8D85Fe</recordid><startdate>199206</startdate><enddate>199206</enddate><creator>BOISSARD, C. G</creator><creator>LINDNER, M. D</creator><creator>GRIBKOFF, V. K</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199206</creationdate><title>Hypoxia produces cell death in the rat hippocampus in the presence of an A1 adenosine receptor antagonist : an anatomical and behavioral study</title><author>BOISSARD, C. G ; LINDNER, M. D ; GRIBKOFF, V. K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c246t-65d5ada3825e4c71a76aa3a38bff82c28771fbd43be15e1f8b209b1d5f9394e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Avoidance Learning - drug effects</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Death - drug effects</topic><topic>Central nervous system</topic><topic>Cognition - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - pathology</topic><topic>Hippocampus - physiopathology</topic><topic>Hypoxia - pathology</topic><topic>Hypoxia - physiopathology</topic><topic>Male</topic><topic>Memory - drug effects</topic><topic>Motor Activity - drug effects</topic><topic>Purinergic Antagonists</topic><topic>Pyramidal Tracts - drug effects</topic><topic>Pyramidal Tracts - pathology</topic><topic>Pyramidal Tracts - physiopathology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Reference Values</topic><topic>Theophylline - analogs & derivatives</topic><topic>Theophylline - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOISSARD, C. G</creatorcontrib><creatorcontrib>LINDNER, M. D</creatorcontrib><creatorcontrib>GRIBKOFF, V. 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K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoxia produces cell death in the rat hippocampus in the presence of an A1 adenosine receptor antagonist : an anatomical and behavioral study</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1992-06</date><risdate>1992</risdate><volume>48</volume><issue>4</issue><spage>807</spage><epage>812</epage><pages>807-812</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Endogenous adenosine depresses synaptic transmission in rat hippocampal slices during periods of hypoxia, a potentially neuroprotective cellular response that is attenuated by the adenosine antagonist 8-cyclopentyltheophylline. In this study, rats were exposed to moderate hypoxic conditions (5% O2- 95% N2, 40 min x three days) in the presence or absence of 8-cyclopentyltheophylline, and the effects of reducing adenosinergic inhibition during hypoxia were assessed histologically and behaviorally. Half the rats exposed to low levels of oxygen in the presence of 8-cyclopentyltheophylline (10 mg/kg) suffered unilateral or bilateral hippocampal damage largely limited to the CA1 subfield. Animals which had suffered hippocampal damage were also impaired in their performance of a working memory version of the Morris Water Maze, but not a passive avoidance task (step-through). Hypoxia alone did not result in neuronal damage or behavioral impairment. These results provide further evidence that endogenous adenosine provides an important level of neuronal protection during even prolonged periods of hypoxia.</abstract><cop>Oxford</cop><pub>Elsevier</pub><pmid>1630626</pmid><doi>10.1016/0306-4522(92)90268-7</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neuroscience, 1992-06, Vol.48 (4), p.807-812 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Avoidance Learning - drug effects Biochemistry and metabolism Biological and medical sciences Cell Death - drug effects Central nervous system Cognition - drug effects Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology Hypoxia - pathology Hypoxia - physiopathology Male Memory - drug effects Motor Activity - drug effects Purinergic Antagonists Pyramidal Tracts - drug effects Pyramidal Tracts - pathology Pyramidal Tracts - physiopathology Rats Rats, Inbred F344 Reference Values Theophylline - analogs & derivatives Theophylline - pharmacology Vertebrates: nervous system and sense organs |
| title | Hypoxia produces cell death in the rat hippocampus in the presence of an A1 adenosine receptor antagonist : an anatomical and behavioral study |
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