Effect of single and repeated oral doses of telithromycin on cardiac QT interval in healthy subjects

Background Telithromycin is the first member of a new class of antimicrobials—the ketolides. The main objective of this study was to assess the effect of various oral doses of telithromycin on QT interval during single and repeated administrations. Methods Seventeen men and 17 women participated in...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2003-03, Vol.73 (3), p.242-252
Hauptverfasser:	Démolis, Jean‐Louis, Vacheron, Françoise, Cardus, Stéphane, Funck‐Brentano, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Analysis of Variance Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Clarithromycin - administration & dosage Clarithromycin - pharmacology Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Electrocardiography - drug effects Exercise Test Female Heart Conduction System - drug effects Humans Ketolides Macrolides Male Medical sciences Pharmacology. Drug treatments Reference Values Rest
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