Artificial‐infection protocols allow immunodetection of novel Borrelia burgdorferi antigens suitable as vaccine candidates against Lyme disease

Vaccination with recombinant outer surface protein A (OspA) from Borrelia burgdorferi provides excellent antibody‐mediated protection against challenge with the pathogen in animal models and in humans. However, the bactericidal antibodies are ineffective in the reservoir host, since OspA is expresse...

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Veröffentlicht in:	European journal of immunology 2003-03, Vol.33 (3), p.708-719
Hauptverfasser:	Wallich, Reinhard, Jahraus, Oliver, Stehle, Thomas, Tran, Thi Thanh Thao, Brenner, Christiane, Hofmann, Heidelore, Gern, Lise, Simon, Markus M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - therapeutic use Antigens, Bacterial - analysis Antigens, Bacterial - immunology Artificial infection Bacterial Vaccines - immunology Base Sequence Borrelia burgdorferi Borrelia burgdorferi - genetics Borrelia burgdorferi - immunology Female Humans Immune Sera - immunology Lyme disease Lyme Disease - prevention & control Mice Mice, SCID Molecular Sequence Data Rabbits Recombinant Proteins - immunology Ticks - microbiology Vaccine Vaccines, Synthetic - immunology
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