Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production

Nitric oxide (NO) production and mononuclear cell NO synthase 2 (NOS2) expression are high in healthy Tanzanian children but low in those with cerebral malaria. Factors that downregulate NOS2 also diminish factors involved in cellular uptake and biosynthesis of L-arginine, the substrate for NO synth...

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Veröffentlicht in:	The Lancet (British edition) 2003-02, Vol.361 (9358), p.676-678
Hauptverfasser:	Lopansri, Bert K, Anstey, Nicholas M, Weinberg, J Brice, Stoddard, Gregory J, Hobbs, Maurine R, Levesque, Marc C, Mwaikambo, Esther D, Granger, Donald L
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine Arginine - blood Biological and medical sciences Biosynthesis Blood Brain Case-Control Studies Child, Preschool Children Children & youth Cryopreservation Cytokines Fatalities Female Human protozoal diseases Humans Infectious diseases Logistic Models Malaria Malaria, Cerebral - blood Male Medical sciences Multivariate analysis Nitric oxide Nitric Oxide - biosynthesis Nitric-oxide synthase Oxidative stress Parasites Parasitic diseases Plasma Plasmodium falciparum Proteins Protozoal diseases Regression analysis Sickle cell disease Substrates Tanzania Tropical medicine Vector-borne diseases
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