Activation of MMP-2 by Porphyromonas gingivalis in human periodontal ligament cells

It has been reported that matrix metalloproteinase (MMP) produced by host cells plays a major role in periodontal tissue destruction. In addition, secreted virulence factors from Porphyromonas gingivalis can alter MMP secretion and cause activation in host cells that lead to the tissue degradation....

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Veröffentlicht in:	Journal of periodontal research 2003-04, Vol.38 (2), p.115-121
Hauptverfasser:	Pattamapun, Kassara, Tiranathanagul, Siriluck, Yongchaitrakul, Tussanee, Kuwatanasuchat, Jintakorn, Pavasant, Prasit
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Culture Techniques Chelating Agents - pharmacology Cysteine Proteinase Inhibitors - pharmacology Dentistry Edetic Acid - pharmacology Enzyme Activation Facial bones, jaws, teeth, parodontium: diseases, semeiology Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Humans Matrix Metalloproteinase 2 - analysis Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase Inhibitors matrix metalloproteinase-2 activation Matrix Metalloproteinases, Membrane-Associated Medical sciences membrane-type-1 matrix metalloproteinase Metalloendopeptidases - analysis Metalloendopeptidases - genetics Non tumoral diseases Otorhinolaryngology. Stomatology Periodontal Ligament - cytology Periodontal Ligament - enzymology periodontal ligament fibroblasts Phenanthrolines - pharmacology Porphyromonas gingivalis - enzymology Porphyromonas gingivalis - metabolism Porphyromonas gingivalis Protein Biosynthesis - genetics Serine Proteinase Inhibitors - pharmacology Time Factors Tissue Inhibitor of Metalloproteinases - pharmacology Transcription, Genetic - genetics Up-Regulation Virulence Factors - metabolism
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