Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy
To compare serum cytokine levels in patients with hyperemesis gravidarum with levels in healthy pregnant and nonpregnant women. Case–control study. Clinical and academic research center. Thirty women with hyperemesis gravidarum, 30 healthy women in the first trimester of pregnancy, and 30 healthy no...
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| Veröffentlicht in: | Fertility and sterility 2003-03, Vol.79 (3), p.498-502 |
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| container_title | Fertility and sterility |
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| creator | Kaplan, Petek Balkanli Gücer, Fatih Sayin, N.Cenk Yüksel, Mahmut Yüce, M.Ali Yardim, Turgut |
| description | To compare serum cytokine levels in patients with hyperemesis gravidarum with levels in healthy pregnant and nonpregnant women.
Case–control study.
Clinical and academic research center.
Thirty women with hyperemesis gravidarum, 30 healthy women in the first trimester of pregnancy, and 30 healthy nonpregnant women.
Serum levels of interleukin-1β, interleukin-2 receptor, interleukin-6, interleukin-8, and tumor necrosis factor (TNF)-α..
Median serum levels of interleukin-2 receptor and interleukin-8 did not differ significantly among the three groups. Serum levels of interleukin-1β and interleukin-6 were significantly higher in healthy pregnant women than in healthy nonpregnant women. Median TNF-α levels were significantly higher in women with hyperemesis (25.8 pg/mL [range, 4.9–140 pg/mL]) than in healthy pregnant and nonpregnant women (10.85 pg/mL [range, 4.1–35.8 pg/mL] and 12 pg/mL [4.3–68.2 pg/mL], respectively).
Levels of TNF-α were significantly higher in patients with hyperemesis gravidarum than in healthy pregnant and nonpregnant women. Thus, TNF-α may be involved in the etiology of hyperemesis gravidarum. |
| doi_str_mv | 10.1016/S0015-0282(02)04699-X |
| format | Article |
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Case–control study.
Clinical and academic research center.
Thirty women with hyperemesis gravidarum, 30 healthy women in the first trimester of pregnancy, and 30 healthy nonpregnant women.
Serum levels of interleukin-1β, interleukin-2 receptor, interleukin-6, interleukin-8, and tumor necrosis factor (TNF)-α..
Median serum levels of interleukin-2 receptor and interleukin-8 did not differ significantly among the three groups. Serum levels of interleukin-1β and interleukin-6 were significantly higher in healthy pregnant women than in healthy nonpregnant women. Median TNF-α levels were significantly higher in women with hyperemesis (25.8 pg/mL [range, 4.9–140 pg/mL]) than in healthy pregnant and nonpregnant women (10.85 pg/mL [range, 4.1–35.8 pg/mL] and 12 pg/mL [4.3–68.2 pg/mL], respectively).
Levels of TNF-α were significantly higher in patients with hyperemesis gravidarum than in healthy pregnant and nonpregnant women. Thus, TNF-α may be involved in the etiology of hyperemesis gravidarum.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(02)04699-X</identifier><identifier>PMID: 12620429</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cytokines - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hyperemesis gravidarum ; Hyperemesis Gravidarum - blood ; Interleukin-1 - blood ; interleukin-1β ; interleukin-2 receptor ; interleukin-6 ; Interleukin-6 - blood ; interleukin-8 ; Interleukin-8 - blood ; Mother. Fetoplacental unit. Mammary gland. Milk ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy. Parturition. Lactation ; Receptors, Interleukin-2 - blood ; TNF-α ; Tumor Necrosis Factor-alpha - analysis ; Vertebrates: reproduction</subject><ispartof>Fertility and sterility, 2003-03, Vol.79 (3), p.498-502</ispartof><rights>2003 American Society for Reproductive Medicine</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-21fa3906b6f127de00de38cadf38880d345d66984be63bec4c7d2d0b045dc29f3</citedby><cites>FETCH-LOGICAL-c490t-21fa3906b6f127de00de38cadf38880d345d66984be63bec4c7d2d0b045dc29f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(02)04699-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14626799$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12620429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaplan, Petek Balkanli</creatorcontrib><creatorcontrib>Gücer, Fatih</creatorcontrib><creatorcontrib>Sayin, N.Cenk</creatorcontrib><creatorcontrib>Yüksel, Mahmut</creatorcontrib><creatorcontrib>Yüce, M.Ali</creatorcontrib><creatorcontrib>Yardim, Turgut</creatorcontrib><title>Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To compare serum cytokine levels in patients with hyperemesis gravidarum with levels in healthy pregnant and nonpregnant women.
Case–control study.
Clinical and academic research center.
Thirty women with hyperemesis gravidarum, 30 healthy women in the first trimester of pregnancy, and 30 healthy nonpregnant women.
Serum levels of interleukin-1β, interleukin-2 receptor, interleukin-6, interleukin-8, and tumor necrosis factor (TNF)-α..
Median serum levels of interleukin-2 receptor and interleukin-8 did not differ significantly among the three groups. Serum levels of interleukin-1β and interleukin-6 were significantly higher in healthy pregnant women than in healthy nonpregnant women. Median TNF-α levels were significantly higher in women with hyperemesis (25.8 pg/mL [range, 4.9–140 pg/mL]) than in healthy pregnant and nonpregnant women (10.85 pg/mL [range, 4.1–35.8 pg/mL] and 12 pg/mL [4.3–68.2 pg/mL], respectively).
Levels of TNF-α were significantly higher in patients with hyperemesis gravidarum than in healthy pregnant and nonpregnant women. Thus, TNF-α may be involved in the etiology of hyperemesis gravidarum.</description><subject>Biological and medical sciences</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hyperemesis gravidarum</subject><subject>Hyperemesis Gravidarum - blood</subject><subject>Interleukin-1 - blood</subject><subject>interleukin-1β</subject><subject>interleukin-2 receptor</subject><subject>interleukin-6</subject><subject>Interleukin-6 - blood</subject><subject>interleukin-8</subject><subject>Interleukin-8 - blood</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Receptors, Interleukin-2 - blood</subject><subject>TNF-α</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Vertebrates: reproduction</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1OGzEURi1EBSnlEUDegMpi6LU945lZIRS1gETFokViZ3ns68QwP8GeBOXt65AIlt1cS9b5rj8fQk4YXDJg8scfAFZkwCv-HfgF5LKus6c9MmFFIbNCFmKfTD6QQ_I1xmcAkKzkB-SQcckh5_WEzH7rEUOvWxoxLDtq1uPw4nukLa6wjdT39G3oME0_zul8vcCAHUYf6Szolbd6E0rQOEfqfIgjHYNPQFpKB0cXAWe97s36G_nidBvxeHcekcdfP_9Ob7P7h5u76fV9ZvIaxowzp0UNspGO8dIigEVRGW2dqKoKrMgLK2Vd5Q1K0aDJTWm5hQbSveG1E0fkfLt3EYbXZeqhOh8Ntq3ucVhGVQqQeSWKBBZb0IQhxoBOLVJxHdaKgdoYVu-G1UZfGurdsHpKudPdA8umQ_uZ2ilNwNkO0NHo1oX0fR8_uVxyWdYb7mrLJc248hhUNB57g9YHNKOyg_9PlX_3x5pE</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Kaplan, Petek Balkanli</creator><creator>Gücer, Fatih</creator><creator>Sayin, N.Cenk</creator><creator>Yüksel, Mahmut</creator><creator>Yüce, M.Ali</creator><creator>Yardim, Turgut</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy</title><author>Kaplan, Petek Balkanli ; Gücer, Fatih ; Sayin, N.Cenk ; Yüksel, Mahmut ; Yüce, M.Ali ; Yardim, Turgut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-21fa3906b6f127de00de38cadf38880d345d66984be63bec4c7d2d0b045dc29f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hyperemesis gravidarum</topic><topic>Hyperemesis Gravidarum - blood</topic><topic>Interleukin-1 - blood</topic><topic>interleukin-1β</topic><topic>interleukin-2 receptor</topic><topic>interleukin-6</topic><topic>Interleukin-6 - blood</topic><topic>interleukin-8</topic><topic>Interleukin-8 - blood</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Receptors, Interleukin-2 - blood</topic><topic>TNF-α</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaplan, Petek Balkanli</creatorcontrib><creatorcontrib>Gücer, Fatih</creatorcontrib><creatorcontrib>Sayin, N.Cenk</creatorcontrib><creatorcontrib>Yüksel, Mahmut</creatorcontrib><creatorcontrib>Yüce, M.Ali</creatorcontrib><creatorcontrib>Yardim, Turgut</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaplan, Petek Balkanli</au><au>Gücer, Fatih</au><au>Sayin, N.Cenk</au><au>Yüksel, Mahmut</au><au>Yüce, M.Ali</au><au>Yardim, Turgut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>79</volume><issue>3</issue><spage>498</spage><epage>502</epage><pages>498-502</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To compare serum cytokine levels in patients with hyperemesis gravidarum with levels in healthy pregnant and nonpregnant women.
Case–control study.
Clinical and academic research center.
Thirty women with hyperemesis gravidarum, 30 healthy women in the first trimester of pregnancy, and 30 healthy nonpregnant women.
Serum levels of interleukin-1β, interleukin-2 receptor, interleukin-6, interleukin-8, and tumor necrosis factor (TNF)-α..
Median serum levels of interleukin-2 receptor and interleukin-8 did not differ significantly among the three groups. Serum levels of interleukin-1β and interleukin-6 were significantly higher in healthy pregnant women than in healthy nonpregnant women. Median TNF-α levels were significantly higher in women with hyperemesis (25.8 pg/mL [range, 4.9–140 pg/mL]) than in healthy pregnant and nonpregnant women (10.85 pg/mL [range, 4.1–35.8 pg/mL] and 12 pg/mL [4.3–68.2 pg/mL], respectively).
Levels of TNF-α were significantly higher in patients with hyperemesis gravidarum than in healthy pregnant and nonpregnant women. Thus, TNF-α may be involved in the etiology of hyperemesis gravidarum.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12620429</pmid><doi>10.1016/S0015-0282(02)04699-X</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Cytokines - blood Female Fundamental and applied biological sciences. Psychology Humans Hyperemesis gravidarum Hyperemesis Gravidarum - blood Interleukin-1 - blood interleukin-1β interleukin-2 receptor interleukin-6 Interleukin-6 - blood interleukin-8 Interleukin-8 - blood Mother. Fetoplacental unit. Mammary gland. Milk Pregnancy Pregnancy Trimester, First Pregnancy. Parturition. Lactation Receptors, Interleukin-2 - blood TNF-α Tumor Necrosis Factor-alpha - analysis Vertebrates: reproduction |
| title | Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy |
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