Microsomal cytochrome P450 levels and activities of isolated rat livers perfused with albumin

We recently showed that the perfusion of isolated rat livers with perfusates containing bovine serum albumin (BSA) would significantly stimulate the release of tumor necrosis factor (TNF)-alpha. Here, we hypothesize that BSA-induced increase in the release of TNF-alpha, and possibly other cytokines,...

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Veröffentlicht in:	Pharmaceutical research 2003, Vol.20 (1), p.81-88
Hauptverfasser:	VUPPUGALLA, Ragini, SHAH, Rakhi B, CHIMALAKONDA, Anjaneya P, FISHER, Charles W, MEHVAR, Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - metabolism Animals Aspartate Aminotransferases - metabolism Bile - drug effects Bile - metabolism Biological and medical sciences Cytochrome P-450 Enzyme System - metabolism Cytokines - metabolism General pharmacology In Vitro Techniques Isoenzymes - metabolism Liver - drug effects Liver - enzymology Liver - metabolism Male Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - enzymology NADH Dehydrogenase - metabolism Nitrates - metabolism Nitrites - metabolism Organ Size - drug effects Perfusion Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Serum Albumin, Bovine - pharmacokinetics Serum Albumin, Bovine - pharmacology
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