Is gastroscopy still a valid diagnostic tool in detecting gastric MALT lymphomas? A dilemma beyond the eye. Mucosa-associated lymphoid tissue
Primary gastric lymphomas are distinct entities with an indolent clinical course and biologic behavior. They account for 2-8% of all gastric malignancies. We conducted this study to evaluate the role of gastroscopy as the principal diagnostic method in detecting gastric MALT lymphomas. Sixty-three c...
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| Veröffentlicht in: | Surgical endoscopy 2003-03, Vol.17 (3), p.469-474 |
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| creator | Kelessis, N G Vassilopoulos, P P Tsamakidis, K G Bai, M G Avital, S Rosenthal, R J |
| description | Primary gastric lymphomas are distinct entities with an indolent clinical course and biologic behavior. They account for 2-8% of all gastric malignancies. We conducted this study to evaluate the role of gastroscopy as the principal diagnostic method in detecting gastric MALT lymphomas.
Sixty-three consecutive patients with gastric MALT lymphomas, who were evaluated and treated at our institution between January 1978 and December 1997, are retrospectively reviewed. There were 36 males and 27 females, with a mean age of 53 years (range 20-80 years). All patients underwent the standard diagnostic evaluation, including gastroscopy and biopsy. Patients were staged according to revised Musshof modification of the Ann Arbor classification system, whereas histological evaluation was made according to the Isaacson classification system for gastric MALT lymphomas.
According to endoscopic findings, the antrum harbored the neoplasm in 31 patients (49%), the body in 38% (24 patients), and the fundus in 4% (3 patients), whereas in 5 patients (8%) the neoplasm occupied the entire stomach. The macroscopic appearance was not in most cases pathognomonic of the disease. Three macroscopic patterns were recognized at endoscopy: (a) the ulcerative in 51% (32 patients), (b) the polypoid in 33% (21 patients) and (c) the diffuse infiltrative in 16% (10 patients). The neoplasm was characterized as a benign disease in 24 patients (38%), with malignancy being suspected in 62% (39 patients). Endoscopy displayed a sensitivity of 61% in detecting malignancy; however, the sensitivity dropped to 27% when endoscopic diagnosis of non-Hodgkin's lymphoma was hypothesized.
Although the impact of gastroscopy as a diagnostic tool in the patients of our study was of limited value, due to the nonspecific gross pattern of gastric MALT lymphomas, it should be maintained in the diagnostic intervention of the upper GI tract pathologies. |
| format | Article |
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Sixty-three consecutive patients with gastric MALT lymphomas, who were evaluated and treated at our institution between January 1978 and December 1997, are retrospectively reviewed. There were 36 males and 27 females, with a mean age of 53 years (range 20-80 years). All patients underwent the standard diagnostic evaluation, including gastroscopy and biopsy. Patients were staged according to revised Musshof modification of the Ann Arbor classification system, whereas histological evaluation was made according to the Isaacson classification system for gastric MALT lymphomas.
According to endoscopic findings, the antrum harbored the neoplasm in 31 patients (49%), the body in 38% (24 patients), and the fundus in 4% (3 patients), whereas in 5 patients (8%) the neoplasm occupied the entire stomach. The macroscopic appearance was not in most cases pathognomonic of the disease. Three macroscopic patterns were recognized at endoscopy: (a) the ulcerative in 51% (32 patients), (b) the polypoid in 33% (21 patients) and (c) the diffuse infiltrative in 16% (10 patients). The neoplasm was characterized as a benign disease in 24 patients (38%), with malignancy being suspected in 62% (39 patients). Endoscopy displayed a sensitivity of 61% in detecting malignancy; however, the sensitivity dropped to 27% when endoscopic diagnosis of non-Hodgkin's lymphoma was hypothesized.
Although the impact of gastroscopy as a diagnostic tool in the patients of our study was of limited value, due to the nonspecific gross pattern of gastric MALT lymphomas, it should be maintained in the diagnostic intervention of the upper GI tract pathologies.</description><identifier>EISSN: 1432-2218</identifier><identifier>PMID: 12404054</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biopsy ; Duodenoscopy ; Esophagoscopy ; Female ; Gastroscopy - methods ; Humans ; Lymphoma, B-Cell, Marginal Zone - diagnosis ; Lymphoma, B-Cell, Marginal Zone - pathology ; Male ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity ; Stomach - pathology ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - pathology</subject><ispartof>Surgical endoscopy, 2003-03, Vol.17 (3), p.469-474</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12404054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelessis, N G</creatorcontrib><creatorcontrib>Vassilopoulos, P P</creatorcontrib><creatorcontrib>Tsamakidis, K G</creatorcontrib><creatorcontrib>Bai, M G</creatorcontrib><creatorcontrib>Avital, S</creatorcontrib><creatorcontrib>Rosenthal, R J</creatorcontrib><title>Is gastroscopy still a valid diagnostic tool in detecting gastric MALT lymphomas? A dilemma beyond the eye. Mucosa-associated lymphoid tissue</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><description>Primary gastric lymphomas are distinct entities with an indolent clinical course and biologic behavior. They account for 2-8% of all gastric malignancies. We conducted this study to evaluate the role of gastroscopy as the principal diagnostic method in detecting gastric MALT lymphomas.
Sixty-three consecutive patients with gastric MALT lymphomas, who were evaluated and treated at our institution between January 1978 and December 1997, are retrospectively reviewed. There were 36 males and 27 females, with a mean age of 53 years (range 20-80 years). All patients underwent the standard diagnostic evaluation, including gastroscopy and biopsy. Patients were staged according to revised Musshof modification of the Ann Arbor classification system, whereas histological evaluation was made according to the Isaacson classification system for gastric MALT lymphomas.
According to endoscopic findings, the antrum harbored the neoplasm in 31 patients (49%), the body in 38% (24 patients), and the fundus in 4% (3 patients), whereas in 5 patients (8%) the neoplasm occupied the entire stomach. The macroscopic appearance was not in most cases pathognomonic of the disease. Three macroscopic patterns were recognized at endoscopy: (a) the ulcerative in 51% (32 patients), (b) the polypoid in 33% (21 patients) and (c) the diffuse infiltrative in 16% (10 patients). The neoplasm was characterized as a benign disease in 24 patients (38%), with malignancy being suspected in 62% (39 patients). Endoscopy displayed a sensitivity of 61% in detecting malignancy; however, the sensitivity dropped to 27% when endoscopic diagnosis of non-Hodgkin's lymphoma was hypothesized.
Although the impact of gastroscopy as a diagnostic tool in the patients of our study was of limited value, due to the nonspecific gross pattern of gastric MALT lymphomas, it should be maintained in the diagnostic intervention of the upper GI tract pathologies.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Duodenoscopy</subject><subject>Esophagoscopy</subject><subject>Female</subject><subject>Gastroscopy - methods</subject><subject>Humans</subject><subject>Lymphoma, B-Cell, Marginal Zone - diagnosis</subject><subject>Lymphoma, B-Cell, Marginal Zone - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Stomach - pathology</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - pathology</subject><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1qwzAQhEWhNGnaVyg69eYiW_KPTiWEtgkk9JK7WcvrREW2XK9c8EP0nWtIelrYnW-HmRu2jJVMoiSJiwW7J_oSQigdp3dsESdKKJGqJfvdET8BhcGT8f3EKVjnOPAfcLbmtYVT5-ed4cF7x23Hawxogu1OF2y-HNb7I3dT2599C_TK1zPmsG2BVzj5rubhjBwnfOGH0XiCCIi8sRCwvmKzU7BEIz6w2wYc4eN1rtjx_e242Ub7z4_dZr2P-lSpqClQohJaNNhgJnVWVQUUutFZIqCRCuNGaTMnTOMiMVprkWcG8iqvVVYZI-SKPV_e9oP_HpFC2Voy6Bx06EcqcykyWUg1C5-uwrFqsS77wbYwTOV_f_IPQtZtaQ</recordid><startdate>200303</startdate><enddate>200303</enddate><creator>Kelessis, N G</creator><creator>Vassilopoulos, P P</creator><creator>Tsamakidis, K G</creator><creator>Bai, M G</creator><creator>Avital, S</creator><creator>Rosenthal, R J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200303</creationdate><title>Is gastroscopy still a valid diagnostic tool in detecting gastric MALT lymphomas? A dilemma beyond the eye. Mucosa-associated lymphoid tissue</title><author>Kelessis, N G ; Vassilopoulos, P P ; Tsamakidis, K G ; Bai, M G ; Avital, S ; Rosenthal, R J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p544-f8e3e4090fefe6396bb8a89f9620af34e1f49c4045182c999076ca7b7d46bcc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy</topic><topic>Duodenoscopy</topic><topic>Esophagoscopy</topic><topic>Female</topic><topic>Gastroscopy - methods</topic><topic>Humans</topic><topic>Lymphoma, B-Cell, Marginal Zone - diagnosis</topic><topic>Lymphoma, B-Cell, Marginal Zone - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Stomach - pathology</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelessis, N G</creatorcontrib><creatorcontrib>Vassilopoulos, P P</creatorcontrib><creatorcontrib>Tsamakidis, K G</creatorcontrib><creatorcontrib>Bai, M G</creatorcontrib><creatorcontrib>Avital, S</creatorcontrib><creatorcontrib>Rosenthal, R J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelessis, N G</au><au>Vassilopoulos, P P</au><au>Tsamakidis, K G</au><au>Bai, M G</au><au>Avital, S</au><au>Rosenthal, R J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is gastroscopy still a valid diagnostic tool in detecting gastric MALT lymphomas? A dilemma beyond the eye. Mucosa-associated lymphoid tissue</atitle><jtitle>Surgical endoscopy</jtitle><addtitle>Surg Endosc</addtitle><date>2003-03</date><risdate>2003</risdate><volume>17</volume><issue>3</issue><spage>469</spage><epage>474</epage><pages>469-474</pages><eissn>1432-2218</eissn><abstract>Primary gastric lymphomas are distinct entities with an indolent clinical course and biologic behavior. They account for 2-8% of all gastric malignancies. We conducted this study to evaluate the role of gastroscopy as the principal diagnostic method in detecting gastric MALT lymphomas.
Sixty-three consecutive patients with gastric MALT lymphomas, who were evaluated and treated at our institution between January 1978 and December 1997, are retrospectively reviewed. There were 36 males and 27 females, with a mean age of 53 years (range 20-80 years). All patients underwent the standard diagnostic evaluation, including gastroscopy and biopsy. Patients were staged according to revised Musshof modification of the Ann Arbor classification system, whereas histological evaluation was made according to the Isaacson classification system for gastric MALT lymphomas.
According to endoscopic findings, the antrum harbored the neoplasm in 31 patients (49%), the body in 38% (24 patients), and the fundus in 4% (3 patients), whereas in 5 patients (8%) the neoplasm occupied the entire stomach. The macroscopic appearance was not in most cases pathognomonic of the disease. Three macroscopic patterns were recognized at endoscopy: (a) the ulcerative in 51% (32 patients), (b) the polypoid in 33% (21 patients) and (c) the diffuse infiltrative in 16% (10 patients). The neoplasm was characterized as a benign disease in 24 patients (38%), with malignancy being suspected in 62% (39 patients). Endoscopy displayed a sensitivity of 61% in detecting malignancy; however, the sensitivity dropped to 27% when endoscopic diagnosis of non-Hodgkin's lymphoma was hypothesized.
Although the impact of gastroscopy as a diagnostic tool in the patients of our study was of limited value, due to the nonspecific gross pattern of gastric MALT lymphomas, it should be maintained in the diagnostic intervention of the upper GI tract pathologies.</abstract><cop>Germany</cop><pmid>12404054</pmid><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biopsy Duodenoscopy Esophagoscopy Female Gastroscopy - methods Humans Lymphoma, B-Cell, Marginal Zone - diagnosis Lymphoma, B-Cell, Marginal Zone - pathology Male Middle Aged Retrospective Studies Sensitivity and Specificity Stomach - pathology Stomach Neoplasms - diagnosis Stomach Neoplasms - pathology |
| title | Is gastroscopy still a valid diagnostic tool in detecting gastric MALT lymphomas? A dilemma beyond the eye. Mucosa-associated lymphoid tissue |
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