Product-assisted catalysis in base-excision DNA repair

Most spontaneous damage to bases in DNA is corrected through the action of the base-excision DNA repair pathway. Base excision repair is initiated by DNA glycosylases, lesion-specific enzymes that intercept aberrant bases in DNA and catalyze their excision. How such proteins accomplish the feat of c...

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Veröffentlicht in:	Nature structural & molecular biology 2003-03, Vol.10 (3), p.204-211
Hauptverfasser:	Verdine, Gregory L, Fromme, J. Christopher, Bruner, Steven D, Yang, Wei, Karplus, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Base Pairing Biochemistry Biological Microscopy Biomedical and Life Sciences Borohydrides - chemistry Catalysis Deoxyribonucleic acid DNA DNA Repair - physiology DNA-Formamidopyrimidine Glycosylase Guanine - analogs & derivatives Guanine - chemistry Guanine - metabolism Imaging, Three-Dimensional Lesions Life Sciences Lysine - chemistry Lysine - metabolism Membrane Biology Models, Molecular N-Glycosyl Hydrolases - chemistry N-Glycosyl Hydrolases - genetics N-Glycosyl Hydrolases - metabolism Protein Conformation Protein Structure Schiff Bases - chemistry Schiff Bases - metabolism
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