The endothelin receptor antagonist, BQ-123, inhibits angiotensin II-induced contractions in rabbit aorta

The purpose of this study was to examine the specificity of the cyclic pentapeptide ET A receptor antagonist BQ-123. BQ-123 competitively antagonized endothelin-1-induced contractions in rabbit aorta, increases in inositol phosphates in cultured rat vascular smooth muscle A10 cells, and binding of [...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1992-06, Vol.185 (3), p.887-892
Hauptverfasser:	Webb, Maria L., Dickinson, Kenneth E.J., Delaney, Carol L., Liu, Eddie C.-K., Serafino, Randy, Cohen, Robert B., Monshizadegan, Hossain, Moreland, Suzanne
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin II Angiotensin II - antagonists & inhibitors Angiotensin II - pharmacology Animals aorta Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Biological and medical sciences Cell Line Cell Membrane - metabolism Cell physiology Cells, Cultured Cerebellum - metabolism Cloning, Molecular contraction endothelin Endothelins - pharmacology Endothelins - physiology Fundamental and applied biological sciences. Psychology Hormonal regulation In Vitro Techniques induction Inositol Phosphates - metabolism Kinetics Molecular and cellular biology Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Norepinephrine - pharmacology Peptides, Cyclic - pharmacology Potassium Chloride - pharmacology Rabbits Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - metabolism Receptors, Cell Surface - physiology Receptors, Endothelin Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - metabolism requirements Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!