Ethanol blocks the cold-induced increase in thyrotropin-releasing hormone mRNA in paraventricular nuclei but not the cold-induced increase in thyrotropin
The effects of a single intraperitoneal injection of ethanol (3 g/kg b.wt.) on the hypothalamic-pituitary-thyroid system was explored as a possible explanation of the hypothermic effect of ethanol. Serum thyroid hormones were significantly reduced by ethanol injection, but ethanol did not affect the...
Gespeichert in:
| Veröffentlicht in: | Brain research. Molecular brain research. 1992-05, Vol.13 (4), p.321-330 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 330 |
|---|---|
| container_issue | 4 |
| container_start_page | 321 |
| container_title | Brain research. Molecular brain research. |
| container_volume | 13 |
| creator | Zoeller, R.Thomas Rudeen, P.Kevin |
| description | The effects of a single intraperitoneal injection of ethanol (3 g/kg b.wt.) on the hypothalamic-pituitary-thyroid system was explored as a possible explanation of the hypothermic effect of ethanol. Serum thyroid hormones were significantly reduced by ethanol injection, but ethanol did not affect the cold-induced increase in serum thyroid hormones or thyroid-stimulating hormone (TSH). Since cold-exposure stimulates serum levels of TSH and thyroid hormones by stimulating thyroid-releasing hormone (TRH) release from neurons of the PVN, these findings demonstrate that ethanol did not block pituitary response to TRH or thyroid response to TSH. Paradoxically, ethanol increased cellular levels of TRH mRNA in the paraventricular nucleus (PVN), and blocked the cold-induced increase in TRH mRNA, suggesting that ethanol uncouples the regulation of TRH gene expression from the regulation of TRH release specifically in neurons of the PVN. Measurements of the effects of ethanol on TRH mRNA in thalamus, and β-actin, vasopressin, somatostain and corticotropin-releasing hormone (CRH) mRNAs in the PVN in addition to TRH mRNA revealed very specific effects of ethanol on the TRH neuronal system. |
| doi_str_mv | 10.1016/0169-328X(92)90215-W |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73063641</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0169328X9290215W</els_id><sourcerecordid>16367316</sourcerecordid><originalsourceid>FETCH-LOGICAL-c332t-2736510e952a4d7e0b84456ebe554b8f712dec8579e919474bf05a1159ff2d323</originalsourceid><addsrcrecordid>eNqNkU2LFDEQhoMo6zj6DxT6IKKH1lQ-ujsXYVnWD1gURFlvIZ2udqLpZDbpXtif4r817QzrTT2kEup9qirUS8hjoC-BQvOqHFVz1n19rtgLRRnI-vIO2UDXsrpRAu6SzS1ynzzI-TulFDqAE3ICXLIG2Ib8PJ93JkRf9T7aH7mad1jZ6IfahWGxOFQu2IQmY3kU8SbFOcW9C3VCX9IufKt2MU0xYDV9-nC6UnuTzDWGOTm7eJOqsFiPruqXuQpx_u8JD8m90fiMj473lnx5c_757F198fHt-7PTi9pyzuaatbyRQFFJZsTQIu07IWSDPUop-m5sgQ1oO9kqVKBEK_qRSgMg1TiygTO-Jc8OffcpXi2YZz25bNF7EzAuWbecNrwR8E8QCtbyErdEHECbYs4JR71PbjLpRgPVq3V69UWvvmjF9G_r9GUpe3Lsv_QTDn-KDl4V_elRN9kaPyYTrMu3mGSUCrZOf33AsCzt2mHS2ToMZdMuoZ31EN3f__ELyA64EQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16367316</pqid></control><display><type>article</type><title>Ethanol blocks the cold-induced increase in thyrotropin-releasing hormone mRNA in paraventricular nuclei but not the cold-induced increase in thyrotropin</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Zoeller, R.Thomas ; Rudeen, P.Kevin</creator><creatorcontrib>Zoeller, R.Thomas ; Rudeen, P.Kevin</creatorcontrib><description>The effects of a single intraperitoneal injection of ethanol (3 g/kg b.wt.) on the hypothalamic-pituitary-thyroid system was explored as a possible explanation of the hypothermic effect of ethanol. Serum thyroid hormones were significantly reduced by ethanol injection, but ethanol did not affect the cold-induced increase in serum thyroid hormones or thyroid-stimulating hormone (TSH). Since cold-exposure stimulates serum levels of TSH and thyroid hormones by stimulating thyroid-releasing hormone (TRH) release from neurons of the PVN, these findings demonstrate that ethanol did not block pituitary response to TRH or thyroid response to TSH. Paradoxically, ethanol increased cellular levels of TRH mRNA in the paraventricular nucleus (PVN), and blocked the cold-induced increase in TRH mRNA, suggesting that ethanol uncouples the regulation of TRH gene expression from the regulation of TRH release specifically in neurons of the PVN. Measurements of the effects of ethanol on TRH mRNA in thalamus, and β-actin, vasopressin, somatostain and corticotropin-releasing hormone (CRH) mRNAs in the PVN in addition to TRH mRNA revealed very specific effects of ethanol on the TRH neuronal system.</description><identifier>ISSN: 0169-328X</identifier><identifier>EISSN: 1872-6941</identifier><identifier>DOI: 10.1016/0169-328X(92)90215-W</identifier><identifier>PMID: 1352612</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Alcoholism and acute alcohol poisoning ; Animals ; Base Sequence ; Biological and medical sciences ; Body Temperature Regulation - drug effects ; Cold ; Cold Temperature ; Corticotropin-Releasing Hormone - biosynthesis ; Corticotropin-Releasing Hormone - genetics ; Depression, Chemical ; Ethanol ; Ethanol - pharmacology ; Gene Expression Regulation - drug effects ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - metabolism ; Hypothermia - chemically induced ; Hypothermia - physiopathology ; Male ; Medical sciences ; Molecular Sequence Data ; Paraventricular Hypothalamic Nucleus - drug effects ; Paraventricular Hypothalamic Nucleus - metabolism ; Paraventricular nucleus ; Rats ; Rats, Inbred Strains ; RNA, Messenger - biosynthesis ; Somatostatin - biosynthesis ; Somatostatin - genetics ; Thyroid Gland - drug effects ; Thyroid Gland - metabolism ; Thyroid Hormones - blood ; Thyrotropin - biosynthesis ; Thyrotropin - genetics ; Thyrotropin-Releasing Hormone - biosynthesis ; Thyrotropin-Releasing Hormone - genetics ; Thyrotropin-releasing hormone mRNA ; Toxicology ; Trans-synaptic regulation, In situ hybridization</subject><ispartof>Brain research. Molecular brain research., 1992-05, Vol.13 (4), p.321-330</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-2736510e952a4d7e0b84456ebe554b8f712dec8579e919474bf05a1159ff2d323</citedby><cites>FETCH-LOGICAL-c332t-2736510e952a4d7e0b84456ebe554b8f712dec8579e919474bf05a1159ff2d323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5200426$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1352612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zoeller, R.Thomas</creatorcontrib><creatorcontrib>Rudeen, P.Kevin</creatorcontrib><title>Ethanol blocks the cold-induced increase in thyrotropin-releasing hormone mRNA in paraventricular nuclei but not the cold-induced increase in thyrotropin</title><title>Brain research. Molecular brain research.</title><addtitle>Brain Res Mol Brain Res</addtitle><description>The effects of a single intraperitoneal injection of ethanol (3 g/kg b.wt.) on the hypothalamic-pituitary-thyroid system was explored as a possible explanation of the hypothermic effect of ethanol. Serum thyroid hormones were significantly reduced by ethanol injection, but ethanol did not affect the cold-induced increase in serum thyroid hormones or thyroid-stimulating hormone (TSH). Since cold-exposure stimulates serum levels of TSH and thyroid hormones by stimulating thyroid-releasing hormone (TRH) release from neurons of the PVN, these findings demonstrate that ethanol did not block pituitary response to TRH or thyroid response to TSH. Paradoxically, ethanol increased cellular levels of TRH mRNA in the paraventricular nucleus (PVN), and blocked the cold-induced increase in TRH mRNA, suggesting that ethanol uncouples the regulation of TRH gene expression from the regulation of TRH release specifically in neurons of the PVN. Measurements of the effects of ethanol on TRH mRNA in thalamus, and β-actin, vasopressin, somatostain and corticotropin-releasing hormone (CRH) mRNAs in the PVN in addition to TRH mRNA revealed very specific effects of ethanol on the TRH neuronal system.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Body Temperature Regulation - drug effects</subject><subject>Cold</subject><subject>Cold Temperature</subject><subject>Corticotropin-Releasing Hormone - biosynthesis</subject><subject>Corticotropin-Releasing Hormone - genetics</subject><subject>Depression, Chemical</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Hypothermia - chemically induced</subject><subject>Hypothermia - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Paraventricular Hypothalamic Nucleus - drug effects</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Paraventricular nucleus</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Somatostatin - biosynthesis</subject><subject>Somatostatin - genetics</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Hormones - blood</subject><subject>Thyrotropin - biosynthesis</subject><subject>Thyrotropin - genetics</subject><subject>Thyrotropin-Releasing Hormone - biosynthesis</subject><subject>Thyrotropin-Releasing Hormone - genetics</subject><subject>Thyrotropin-releasing hormone mRNA</subject><subject>Toxicology</subject><subject>Trans-synaptic regulation, In situ hybridization</subject><issn>0169-328X</issn><issn>1872-6941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2LFDEQhoMo6zj6DxT6IKKH1lQ-ujsXYVnWD1gURFlvIZ2udqLpZDbpXtif4r817QzrTT2kEup9qirUS8hjoC-BQvOqHFVz1n19rtgLRRnI-vIO2UDXsrpRAu6SzS1ynzzI-TulFDqAE3ICXLIG2Ib8PJ93JkRf9T7aH7mad1jZ6IfahWGxOFQu2IQmY3kU8SbFOcW9C3VCX9IufKt2MU0xYDV9-nC6UnuTzDWGOTm7eJOqsFiPruqXuQpx_u8JD8m90fiMj473lnx5c_757F198fHt-7PTi9pyzuaatbyRQFFJZsTQIu07IWSDPUop-m5sgQ1oO9kqVKBEK_qRSgMg1TiygTO-Jc8OffcpXi2YZz25bNF7EzAuWbecNrwR8E8QCtbyErdEHECbYs4JR71PbjLpRgPVq3V69UWvvmjF9G_r9GUpe3Lsv_QTDn-KDl4V_elRN9kaPyYTrMu3mGSUCrZOf33AsCzt2mHS2ToMZdMuoZ31EN3f__ELyA64EQ</recordid><startdate>199205</startdate><enddate>199205</enddate><creator>Zoeller, R.Thomas</creator><creator>Rudeen, P.Kevin</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>199205</creationdate><title>Ethanol blocks the cold-induced increase in thyrotropin-releasing hormone mRNA in paraventricular nuclei but not the cold-induced increase in thyrotropin</title><author>Zoeller, R.Thomas ; Rudeen, P.Kevin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-2736510e952a4d7e0b84456ebe554b8f712dec8579e919474bf05a1159ff2d323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Body Temperature Regulation - drug effects</topic><topic>Cold</topic><topic>Cold Temperature</topic><topic>Corticotropin-Releasing Hormone - biosynthesis</topic><topic>Corticotropin-Releasing Hormone - genetics</topic><topic>Depression, Chemical</topic><topic>Ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - metabolism</topic><topic>Hypothermia - chemically induced</topic><topic>Hypothermia - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Paraventricular Hypothalamic Nucleus - drug effects</topic><topic>Paraventricular Hypothalamic Nucleus - metabolism</topic><topic>Paraventricular nucleus</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Somatostatin - biosynthesis</topic><topic>Somatostatin - genetics</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Hormones - blood</topic><topic>Thyrotropin - biosynthesis</topic><topic>Thyrotropin - genetics</topic><topic>Thyrotropin-Releasing Hormone - biosynthesis</topic><topic>Thyrotropin-Releasing Hormone - genetics</topic><topic>Thyrotropin-releasing hormone mRNA</topic><topic>Toxicology</topic><topic>Trans-synaptic regulation, In situ hybridization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zoeller, R.Thomas</creatorcontrib><creatorcontrib>Rudeen, P.Kevin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research. Molecular brain research.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zoeller, R.Thomas</au><au>Rudeen, P.Kevin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethanol blocks the cold-induced increase in thyrotropin-releasing hormone mRNA in paraventricular nuclei but not the cold-induced increase in thyrotropin</atitle><jtitle>Brain research. Molecular brain research.</jtitle><addtitle>Brain Res Mol Brain Res</addtitle><date>1992-05</date><risdate>1992</risdate><volume>13</volume><issue>4</issue><spage>321</spage><epage>330</epage><pages>321-330</pages><issn>0169-328X</issn><eissn>1872-6941</eissn><abstract>The effects of a single intraperitoneal injection of ethanol (3 g/kg b.wt.) on the hypothalamic-pituitary-thyroid system was explored as a possible explanation of the hypothermic effect of ethanol. Serum thyroid hormones were significantly reduced by ethanol injection, but ethanol did not affect the cold-induced increase in serum thyroid hormones or thyroid-stimulating hormone (TSH). Since cold-exposure stimulates serum levels of TSH and thyroid hormones by stimulating thyroid-releasing hormone (TRH) release from neurons of the PVN, these findings demonstrate that ethanol did not block pituitary response to TRH or thyroid response to TSH. Paradoxically, ethanol increased cellular levels of TRH mRNA in the paraventricular nucleus (PVN), and blocked the cold-induced increase in TRH mRNA, suggesting that ethanol uncouples the regulation of TRH gene expression from the regulation of TRH release specifically in neurons of the PVN. Measurements of the effects of ethanol on TRH mRNA in thalamus, and β-actin, vasopressin, somatostain and corticotropin-releasing hormone (CRH) mRNAs in the PVN in addition to TRH mRNA revealed very specific effects of ethanol on the TRH neuronal system.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1352612</pmid><doi>10.1016/0169-328X(92)90215-W</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-328X |
| ispartof | Brain research. Molecular brain research., 1992-05, Vol.13 (4), p.321-330 |
| issn | 0169-328X 1872-6941 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73063641 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Alcoholism and acute alcohol poisoning Animals Base Sequence Biological and medical sciences Body Temperature Regulation - drug effects Cold Cold Temperature Corticotropin-Releasing Hormone - biosynthesis Corticotropin-Releasing Hormone - genetics Depression, Chemical Ethanol Ethanol - pharmacology Gene Expression Regulation - drug effects Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Hypothermia - chemically induced Hypothermia - physiopathology Male Medical sciences Molecular Sequence Data Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - metabolism Paraventricular nucleus Rats Rats, Inbred Strains RNA, Messenger - biosynthesis Somatostatin - biosynthesis Somatostatin - genetics Thyroid Gland - drug effects Thyroid Gland - metabolism Thyroid Hormones - blood Thyrotropin - biosynthesis Thyrotropin - genetics Thyrotropin-Releasing Hormone - biosynthesis Thyrotropin-Releasing Hormone - genetics Thyrotropin-releasing hormone mRNA Toxicology Trans-synaptic regulation, In situ hybridization |
| title | Ethanol blocks the cold-induced increase in thyrotropin-releasing hormone mRNA in paraventricular nuclei but not the cold-induced increase in thyrotropin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T15%3A23%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ethanol%20blocks%20the%20cold-induced%20increase%20in%20thyrotropin-releasing%20hormone%20mRNA%20in%20paraventricular%20nuclei%20but%20not%20the%20cold-induced%20increase%20in%20thyrotropin&rft.jtitle=Brain%20research.%20Molecular%20brain%20research.&rft.au=Zoeller,%20R.Thomas&rft.date=1992-05&rft.volume=13&rft.issue=4&rft.spage=321&rft.epage=330&rft.pages=321-330&rft.issn=0169-328X&rft.eissn=1872-6941&rft_id=info:doi/10.1016/0169-328X(92)90215-W&rft_dat=%3Cproquest_cross%3E16367316%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16367316&rft_id=info:pmid/1352612&rft_els_id=0169328X9290215W&rfr_iscdi=true |