Hematologic effects of inactivating the Ras processing enzyme Rce1

Posttranslational processing of Ras proteins has attracted considerable interest as a potential target for anticancer drug discovery. Rce1 encodes an endoprotease that facilitates membrane targeting of Ras and other prenylated proteins by releasing the carboxyl-terminal 3 amino acids (ie, the -AAX o...

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Veröffentlicht in:	Blood 2003-03, Vol.101 (6), p.2250-2252
Hauptverfasser:	Aiyagari, Abigail L, Taylor, Brigit R, Aurora, Vikas, Young, Stephen G, Shannon, Kevin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Bone Marrow Cells - enzymology Endopeptidases - deficiency Endopeptidases - genetics Endopeptidases - physiology Enzyme Activation Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Hematopoiesis - radiation effects Hematopoietic Stem Cell Transplantation Heterozygote Leukocyte Count Liver - cytology Liver - embryology Mice Mice, Inbred C57BL Mice, Knockout Mitogen-Activated Protein Kinases - metabolism Mutation
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