Characterization of (−)-Matairesinol as a Potent Inhibitor of Casein Kinase I in Vitro

The inhibitory effects of (−)-matairesinol (MTS) isolated from Thujopsis dolabrata var. hondai on the activities of four distinct Ser/Thr-protein kinases [two casein kinases (CK-I and CK-II), A-kinase and C-kinase] were determined in vitro. It was found that (i) MTS inhibits the activities of CK-I a...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2003, Vol.26(3), pp.371-374
Hauptverfasser:	Yokoyama, Takamasa, Okano, Maiko, Noshita, Toshiro, Funayama, Shinji, Ohtsuki, Kenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	(−)-matairesinol Autoradiography - methods Biological and medical sciences casein kinase I Casein Kinases Creatine Kinase - classification Creatine Kinase - drug effects Creatine Kinase - metabolism Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Furans - pharmacology In Vitro Techniques Kinetics Lignans - pharmacology Medical sciences Phosphorus Isotopes - metabolism Phosphorylation - drug effects potent CK-I inhibitor Protein Kinase Inhibitors Protein Kinases - classification Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Substrate Specificity Thujopsis dolabrata var. hondai
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