The thrombomodulin-protein C system is essential for the maintenance of pregnancy

Disruption of the mouse gene encoding the blood coagulation inhibitor thrombomodulin (Thbd) leads to embryonic lethality caused by an unknown defect in the placenta. We show that the abortion of thrombomodulin-deficient embryos is caused by tissue factor-initiated activation of the blood coagulation...

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Veröffentlicht in:	Nature medicine 2003-03, Vol.9 (3), p.331-337
Hauptverfasser:	Weiler, Hartmut, Isermann, Berend, Sood, Rashmi, Pawlinski, Rafal, Zogg, Mark, Kalloway, Shawn, Degen, Jay L, Mackman, Nigel
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Spontaneous Animals Blood Coagulation - physiology Cell Division - physiology Coagulation Degradation products Embryo Loss Embryo, Mammalian - anatomy & histology Embryo, Mammalian - physiology Embryos Female Fibrin - metabolism Fibrinogen - genetics Fibrinogen - metabolism Fibrinolysin - metabolism In Situ Hybridization In Situ Nick-End Labeling Male Mice Mice, Inbred C57BL Mortality Placenta - cytology Placenta - metabolism Pregnancy Pregnancy Maintenance Protein C - metabolism Receptor, PAR-2 Receptors, Thrombin - metabolism Thrombin - metabolism Thrombomodulin - genetics Thrombomodulin - metabolism Thromboplastin - genetics Thromboplastin - metabolism Trophoblasts - cytology Trophoblasts - metabolism
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