In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E
The activities of three mycotoxins isolated from the hyphomycete Metarhizium anisopliae: destruxin A, B, and E (DA, DB and DE) are described and compared in vitro on leukemic cells. Their antitumor effect was investigated by flow cytometry on growth, cell viability and cell cycle perturbation 48 h a...
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| Veröffentlicht in: | Biology of the cell 1992, Vol.74 (3), p.267-271 |
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| container_title | Biology of the cell |
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| creator | Odier, Françoise Vey, Alain Bureau, JP |
| description | The activities of three mycotoxins isolated from the hyphomycete
Metarhizium anisopliae: destruxin A, B, and E (DA, DB and DE) are described and compared
in vitro on leukemic cells. Their antitumor effect was investigated by flow cytometry on growth, cell viability and cell cycle perturbation 48 h after destruxin exposure. Against P388 leukemic cells, DE displayed greater antiproliferative activity than DA and DB. The minimum concentration required to inhibit 50% of cell proliferation is 0.33 μg/ml for DE, 11.7 μg/ml for DA and 9.4 μg/ml for DB. Cell cycle modifications were only observed with DE at 50 and 10 μg/ml and consisted in an accumulation of the cells in GO/1 phase. DA and DB did not modify the number of cells in G0/1 of the cell cycle. Nevertheless a decrease in the number of cells in G2 + M phase was induced by the three destruxins. |
| doi_str_mv | 10.1016/0248-4900(92)90037-2 |
| format | Article |
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Metarhizium anisopliae: destruxin A, B, and E (DA, DB and DE) are described and compared
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Metarhizium anisopliae: destruxin A, B, and E (DA, DB and DE) are described and compared
in vitro on leukemic cells. Their antitumor effect was investigated by flow cytometry on growth, cell viability and cell cycle perturbation 48 h after destruxin exposure. Against P388 leukemic cells, DE displayed greater antiproliferative activity than DA and DB. The minimum concentration required to inhibit 50% of cell proliferation is 0.33 μg/ml for DE, 11.7 μg/ml for DA and 9.4 μg/ml for DB. Cell cycle modifications were only observed with DE at 50 and 10 μg/ml and consisted in an accumulation of the cells in GO/1 phase. DA and DB did not modify the number of cells in G0/1 of the cell cycle. Nevertheless a decrease in the number of cells in G2 + M phase was induced by the three destruxins.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>antiproliferative activity</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Division - drug effects</subject><subject>Depression, Chemical</subject><subject>Depsipeptides</subject><subject>destruxin</subject><subject>DNA</subject><subject>flow cytometry</subject><subject>Fungal Proteins</subject><subject>Interphase - drug effects</subject><subject>Leukemia P388 - pathology</subject><subject>Mice</subject><subject>Mice, Inbred DBA</subject><subject>mouse leukemic cells</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Structure-Activity Relationship</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>0248-4900</issn><issn>1768-322X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1TAQhS0EKpfCPwDJK1QkUvyMHRZI7VUpVSvKgkfFAstxxsg0N0ntpPT-e5ymKjvEahbnnNGZbxB6Tsk-JbR8Q5jQhagI2avYqzy4KtgDtKKq1AVn7OIhWt1bHqMnKf0ihIhKyx20Q0umKSUr9OOkw9dhjD0G78GNuPfYT91P22K3dW3fwJDCAMMYGki473AL0yVsgsMO2ja9xWmcmu2cyvoYp5vQJXzwGh9i2zX46Cl65G2b4Nnd3EVf3h99Xn8ozs6PT9YHZ4UTrJQF5V5yJ3y-QVXMSud96Shwa2tNpHKVrG3jfO15JVQpS5WrUqZZ3ehKUi74Lnq57B1ifzXlJmYT0tzQdtBPyShOSqIZz0axGF3sU4rgzRDDxsatocTMWM3MzMzMTMXMLVbDcuzF3f6p3kDzN7RwzHq16L9DC9v_2mkOz9e5kMzZYsmGNMLNfdbGS1MqrqT59vHYnH76yr-LC33b5d3ihwz0OkA0yQXoHDQh5g-apg__PuYPp46l6A</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Odier, Françoise</creator><creator>Vey, Alain</creator><creator>Bureau, JP</creator><general>Elsevier SAS</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E</title><author>Odier, Françoise ; Vey, Alain ; Bureau, JP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4265-13f53c4f037792a5cff6c1e3aab8057c95badcfbf39476567fec1282bd8951343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>antiproliferative activity</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Division - drug effects</topic><topic>Depression, Chemical</topic><topic>Depsipeptides</topic><topic>destruxin</topic><topic>DNA</topic><topic>flow cytometry</topic><topic>Fungal Proteins</topic><topic>Interphase - drug effects</topic><topic>Leukemia P388 - pathology</topic><topic>Mice</topic><topic>Mice, Inbred DBA</topic><topic>mouse leukemic cells</topic><topic>Peptides, Cyclic - pharmacology</topic><topic>Structure-Activity Relationship</topic><topic>Tumor Cells, Cultured - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Odier, Françoise</creatorcontrib><creatorcontrib>Vey, Alain</creatorcontrib><creatorcontrib>Bureau, JP</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of the cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Odier, Françoise</au><au>Vey, Alain</au><au>Bureau, JP</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E</atitle><jtitle>Biology of the cell</jtitle><addtitle>Biol Cell</addtitle><date>1992</date><risdate>1992</risdate><volume>74</volume><issue>3</issue><spage>267</spage><epage>271</epage><pages>267-271</pages><issn>0248-4900</issn><eissn>1768-322X</eissn><abstract>The activities of three mycotoxins isolated from the hyphomycete
Metarhizium anisopliae: destruxin A, B, and E (DA, DB and DE) are described and compared
in vitro on leukemic cells. Their antitumor effect was investigated by flow cytometry on growth, cell viability and cell cycle perturbation 48 h after destruxin exposure. Against P388 leukemic cells, DE displayed greater antiproliferative activity than DA and DB. The minimum concentration required to inhibit 50% of cell proliferation is 0.33 μg/ml for DE, 11.7 μg/ml for DA and 9.4 μg/ml for DB. Cell cycle modifications were only observed with DE at 50 and 10 μg/ml and consisted in an accumulation of the cells in GO/1 phase. DA and DB did not modify the number of cells in G0/1 of the cell cycle. Nevertheless a decrease in the number of cells in G2 + M phase was induced by the three destruxins.</abstract><cop>Oxford, UK</cop><pub>Elsevier SAS</pub><pmid>1628110</pmid><doi>10.1016/0248-4900(92)90037-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biology of the cell, 1992, Vol.74 (3), p.267-271 |
| issn | 0248-4900 1768-322X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antineoplastic Agents - pharmacology antiproliferative activity Cell Cycle - drug effects Cell Division - drug effects Depression, Chemical Depsipeptides destruxin DNA flow cytometry Fungal Proteins Interphase - drug effects Leukemia P388 - pathology Mice Mice, Inbred DBA mouse leukemic cells Peptides, Cyclic - pharmacology Structure-Activity Relationship Tumor Cells, Cultured - drug effects |
| title | In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E |
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