Role of hepatic lysosomes in the degradation of metallothionein

The degradation of metallothionein (MT) by rat liver was examined. Degradation of MT by liver homogenate was greater than by cytosol. In addition, MT degradation by the homogenate at pH 5.5 was more than that at pH 7.2. Because lysosomal proteases function at acidic pH, these findings suggest the im...

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Veröffentlicht in:	Toxicology and applied pharmacology 1992-07, Vol.115 (1), p.64-71
Hauptverfasser:	Choudhuri, Supratim, McKim, James M., Klaassen, Curtis D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cathepsins - antagonists & inhibitors Cathepsins - metabolism Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Leucine - analogs & derivatives Leucine - pharmacology Leupeptins - pharmacology Liver - cytology Liver - metabolism Lysosomes - enzymology Lysosomes - metabolism Male Metalloproteins Metallothionein - metabolism Other metalloproteins Pepstatins - pharmacology Proteins Rats Rats, Inbred Strains
Online-Zugang:	Volltext
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