A high-performance liquid chromatographic assay for CI-973, a new anticancer platinum diamine complex, in human plasma and urine ultrafiltrates

CI-973 is a new platinum compound with antitumor properties that is currently undergoing phase II clinical trials. A high-performance liquid chromatographic (HPLC) assay was developed and validated for ultrafiltrates of human plasma and urine to support phase I clinical trials. Plasma ultrafiltrate...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1992, Vol.30 (3), p.193-198
Hauptverfasser:	BULLEN, W. W, ANDRESS, L. D, TSUN CHANG, WHITFIELD, L. R, WELCH, M. L, NEWMAN, R. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents - blood Antineoplastic Agents - urine Biological and medical sciences Carboplatin - analogs & derivatives Carboplatin - blood Carboplatin - urine Chromatography, High Pressure Liquid - methods Drug Stability General pharmacology Humans Medical sciences Pharmacology. Drug treatments Ultrafiltration Water
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