Biomechanical Properties of Reperfused Transmural Myocardial Infarcts in Rabbits During the First Week After Infarction: Implications for Left Ventricular Rupture
Left ventricular (lv) rupture potential was studied after transmural myocardial infarction (MI) in rabbits by measuring 1) the tensile strength of infarcted tissue strips, 2) the force required to initiate a tear (tear threshold) in the central infarcted region, and 3) the intracavitary pressure req...
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| Veröffentlicht in: | Circulation research 1992-08, Vol.71 (2), p.401-413 |
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| creator | Connelly, Carolyn M Ngoy, Soeun Schoen, Frederick J Apstein, Carl S |
| description | Left ventricular (lv) rupture potential was studied after transmural myocardial infarction (MI) in rabbits by measuring 1) the tensile strength of infarcted tissue strips, 2) the force required to initiate a tear (tear threshold) in the central infarcted region, and 3) the intracavitary pressure required to rupture the infarcted ventricle. During the first week after MI, infarcts resulting from a permanent coronary occlusion were compared with infarcts reperfused “late” (i.e., 3 hours) after coronary occlusion with a resultant hemorrhagic transmural infarct but no reduction in infarct size. The reperfused hemorrhagic infarcted strips had less tensile strength than strips from permanently occluded infarcts in the initial 24 hours after MI (16±1 versus 24±3 g/mm, p |
| doi_str_mv | 10.1161/01.res.71.2.401 |
| format | Article |
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During the first week after MI, infarcts resulting from a permanent coronary occlusion were compared with infarcts reperfused “late” (i.e., 3 hours) after coronary occlusion with a resultant hemorrhagic transmural infarct but no reduction in infarct size. The reperfused hemorrhagic infarcted strips had less tensile strength than strips from permanently occluded infarcts in the initial 24 hours after MI (16±1 versus 24±3 g/mm, p<0.05), but the tear threshold and response to increased lv pressure were not influenced by infarct reperfusion at this time. By 3 days after MI, reperfused infarcts had equal tensile strength, had greater resistance to infarct tearing, and could withstand a greater lv distending pressure compared with permanently occluded infarcts. By 5 days after MI, reperfused infarcts maintained a greater tear threshold but had less tensile strength than permanently occluded infarcts, although all infarct values were equivalent or greater than normal lv values. By 7 days after MI, reperfused and permanently occluded infarcts were equally strong by all measurements. Thus, late reperfusion of transmural infarcts increased resistance to infarct tearing and lv rupture above that of nonreperfused permanently occluded infarcts by 3 days after MI and enhanced tissue strength after an initial 24-hour vulnerable period. These findings suggest that late reperfusion may accelerate myocardial healing after MI.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.res.71.2.401</identifier><identifier>PMID: 1628396</identifier><identifier>CODEN: CIRUAL</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Animals ; Biological and medical sciences ; Biomechanical Phenomena ; Fundamental and applied biological sciences. Psychology ; Heart - physiopathology ; Heart Rupture, Post-Infarction - etiology ; Heart Ventricles - physiopathology ; Hemodynamics. Rheology ; Male ; Myocardial Infarction - physiopathology ; Myocardial Reperfusion ; Myocardial Reperfusion Injury - physiopathology ; Rabbits ; Tensile Strength ; Time Factors ; Vertebrates: cardiovascular system</subject><ispartof>Circulation research, 1992-08, Vol.71 (2), p.401-413</ispartof><rights>1992 American Heart Association, Inc.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5098-58b4a45ac117f10ef1434aff45eedc8266cd1f7371efcc3ce3bd82b488a29933</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4354160$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1628396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Connelly, Carolyn M</creatorcontrib><creatorcontrib>Ngoy, Soeun</creatorcontrib><creatorcontrib>Schoen, Frederick J</creatorcontrib><creatorcontrib>Apstein, Carl S</creatorcontrib><title>Biomechanical Properties of Reperfused Transmural Myocardial Infarcts in Rabbits During the First Week After Infarction: Implications for Left Ventricular Rupture</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>Left ventricular (lv) rupture potential was studied after transmural myocardial infarction (MI) in rabbits by measuring 1) the tensile strength of infarcted tissue strips, 2) the force required to initiate a tear (tear threshold) in the central infarcted region, and 3) the intracavitary pressure required to rupture the infarcted ventricle. During the first week after MI, infarcts resulting from a permanent coronary occlusion were compared with infarcts reperfused “late” (i.e., 3 hours) after coronary occlusion with a resultant hemorrhagic transmural infarct but no reduction in infarct size. The reperfused hemorrhagic infarcted strips had less tensile strength than strips from permanently occluded infarcts in the initial 24 hours after MI (16±1 versus 24±3 g/mm, p<0.05), but the tear threshold and response to increased lv pressure were not influenced by infarct reperfusion at this time. By 3 days after MI, reperfused infarcts had equal tensile strength, had greater resistance to infarct tearing, and could withstand a greater lv distending pressure compared with permanently occluded infarcts. By 5 days after MI, reperfused infarcts maintained a greater tear threshold but had less tensile strength than permanently occluded infarcts, although all infarct values were equivalent or greater than normal lv values. By 7 days after MI, reperfused and permanently occluded infarcts were equally strong by all measurements. Thus, late reperfusion of transmural infarcts increased resistance to infarct tearing and lv rupture above that of nonreperfused permanently occluded infarcts by 3 days after MI and enhanced tissue strength after an initial 24-hour vulnerable period. These findings suggest that late reperfusion may accelerate myocardial healing after MI.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart - physiopathology</subject><subject>Heart Rupture, Post-Infarction - etiology</subject><subject>Heart Ventricles - physiopathology</subject><subject>Hemodynamics. Rheology</subject><subject>Male</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Reperfusion</subject><subject>Myocardial Reperfusion Injury - physiopathology</subject><subject>Rabbits</subject><subject>Tensile Strength</subject><subject>Time Factors</subject><subject>Vertebrates: cardiovascular system</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1vFDEMhiMEKkvhzAkpB8RttnGS-eJWSgsrLQItKzhGmYzDhs5MhmSiqn-HX0qqXeBgxa_82Fb8EvIS2BqgggsG64BxXcOaryWDR2QFJZeFLGt4TFaMsbaohWBPybMYfzIGUvD2jJxBxRvRVivy-53zI5qDnpzRA_0S_IxhcRipt3SHWdgUsaf7oKc4ppCZT_fe6NC7nG4mq4NZInUT3emuczl9n4KbftDlgPTGhbjQ74i39NIuGP7yzk9v6Wach7zzQURqfaBbtAv9htMSnEmDDnSX5iUFfE6eWD1EfHF6z8n-5np_9bHYfv6wubrcFqZkbVOUTSe1LLUBqC0wtPmvUlsrS8TeNLyqTA-2FjWgNUYYFF3f8E42jeZtK8Q5eXMcOwf_K2Fc1OiiwWHQE_oUVS1Y2XIhM3hxBE3wMQa0ag5u1OFeAVMPpigGanf9VdWguMqm5I5Xp9GpG7H_zx9dyPXXp7qO2QWbb21c_IdJUUqoWMbkEbvzQ75mvB3SHQZ1QD0sB5W9ZoIBL6BtOWuyKnJAI_4Alfin-Q</recordid><startdate>199208</startdate><enddate>199208</enddate><creator>Connelly, Carolyn M</creator><creator>Ngoy, Soeun</creator><creator>Schoen, Frederick J</creator><creator>Apstein, Carl S</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199208</creationdate><title>Biomechanical Properties of Reperfused Transmural Myocardial Infarcts in Rabbits During the First Week After Infarction: Implications for Left Ventricular Rupture</title><author>Connelly, Carolyn M ; Ngoy, Soeun ; Schoen, Frederick J ; Apstein, Carl S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5098-58b4a45ac117f10ef1434aff45eedc8266cd1f7371efcc3ce3bd82b488a29933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart - physiopathology</topic><topic>Heart Rupture, Post-Infarction - etiology</topic><topic>Heart Ventricles - physiopathology</topic><topic>Hemodynamics. Rheology</topic><topic>Male</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Reperfusion</topic><topic>Myocardial Reperfusion Injury - physiopathology</topic><topic>Rabbits</topic><topic>Tensile Strength</topic><topic>Time Factors</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Connelly, Carolyn M</creatorcontrib><creatorcontrib>Ngoy, Soeun</creatorcontrib><creatorcontrib>Schoen, Frederick J</creatorcontrib><creatorcontrib>Apstein, Carl S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Connelly, Carolyn M</au><au>Ngoy, Soeun</au><au>Schoen, Frederick J</au><au>Apstein, Carl S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomechanical Properties of Reperfused Transmural Myocardial Infarcts in Rabbits During the First Week After Infarction: Implications for Left Ventricular Rupture</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1992-08</date><risdate>1992</risdate><volume>71</volume><issue>2</issue><spage>401</spage><epage>413</epage><pages>401-413</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><coden>CIRUAL</coden><abstract>Left ventricular (lv) rupture potential was studied after transmural myocardial infarction (MI) in rabbits by measuring 1) the tensile strength of infarcted tissue strips, 2) the force required to initiate a tear (tear threshold) in the central infarcted region, and 3) the intracavitary pressure required to rupture the infarcted ventricle. During the first week after MI, infarcts resulting from a permanent coronary occlusion were compared with infarcts reperfused “late” (i.e., 3 hours) after coronary occlusion with a resultant hemorrhagic transmural infarct but no reduction in infarct size. The reperfused hemorrhagic infarcted strips had less tensile strength than strips from permanently occluded infarcts in the initial 24 hours after MI (16±1 versus 24±3 g/mm, p<0.05), but the tear threshold and response to increased lv pressure were not influenced by infarct reperfusion at this time. By 3 days after MI, reperfused infarcts had equal tensile strength, had greater resistance to infarct tearing, and could withstand a greater lv distending pressure compared with permanently occluded infarcts. By 5 days after MI, reperfused infarcts maintained a greater tear threshold but had less tensile strength than permanently occluded infarcts, although all infarct values were equivalent or greater than normal lv values. By 7 days after MI, reperfused and permanently occluded infarcts were equally strong by all measurements. Thus, late reperfusion of transmural infarcts increased resistance to infarct tearing and lv rupture above that of nonreperfused permanently occluded infarcts by 3 days after MI and enhanced tissue strength after an initial 24-hour vulnerable period. These findings suggest that late reperfusion may accelerate myocardial healing after MI.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>1628396</pmid><doi>10.1161/01.res.71.2.401</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation research, 1992-08, Vol.71 (2), p.401-413 |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biological and medical sciences Biomechanical Phenomena Fundamental and applied biological sciences. Psychology Heart - physiopathology Heart Rupture, Post-Infarction - etiology Heart Ventricles - physiopathology Hemodynamics. Rheology Male Myocardial Infarction - physiopathology Myocardial Reperfusion Myocardial Reperfusion Injury - physiopathology Rabbits Tensile Strength Time Factors Vertebrates: cardiovascular system |
| title | Biomechanical Properties of Reperfused Transmural Myocardial Infarcts in Rabbits During the First Week After Infarction: Implications for Left Ventricular Rupture |
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