Selective Ligands and Cellular Effectors of a G Protein-Coupled Endothelial Cannabinoid Receptor

The cannabinoid analog abnormal cannabidiol [abn-cbd; (−)-4-(3–3,4-trans-p-menthadien-[1,8]-yl)-olivetol] does not bind to CB1 or CB2 receptors, yet it acts as a full agonist in relaxing rat isolated mesenteric artery segments. Vasorelaxation by abn-cbd is endothelium-dependent, pertussis toxin-sens...

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Veröffentlicht in:	Molecular pharmacology 2003-03, Vol.63 (3), p.699-705
Hauptverfasser:	Offertáler, László, Mo, Fong-Ming, Bátkai, Sándor, Liu, Jie, Begg, Malcolm, Razdan, Raj K, Martin, Billy R, Bukoski, Richard D, Kunos, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cannabidiol - pharmacology Endothelium, Vascular - physiology GTP-Binding Proteins - metabolism Humans In Vitro Techniques Ligands Male Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB2 Receptors, Cannabinoid Receptors, Drug - physiology Vasodilation - drug effects
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