The development of COX2 inhibitors

Key Points Prostaglandins are bioactive lipids that have potent actions in both pathological (inflammation, fever and pain) and physiological (protection of gastric mucosa, platelet agrregation) events. Prostaglandins are formed enzymatically by the cyclooxygenase (COX1) enzyme from unesterified fat...

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Veröffentlicht in:	Nature reviews. Drug discovery 2003-03, Vol.2 (3), p.179-191
1. Verfasser:	Flower, Rod J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biomedical and Life Sciences Biomedicine Biotechnology Cancer Research COX-2 inhibitors Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Drug Design Humans Isoenzymes - metabolism Isoenzymes - physiology Medicinal Chemistry Membrane Proteins Molecular Medicine Nonsteroidal anti-inflammatory drugs Pharmacology/Toxicology Product development Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandin-Endoperoxide Synthases - physiology review-article Structure-Activity Relationship
Online-Zugang:	Volltext
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