Value of external irradiation for locally advanced papillary thyroid cancer
To look for the possible efficacy of external beam irradiation (EBRT) for locally advanced papillary thyroid cancers Between August 1981 and September 1997, 91 patients with locally advanced papillary thyroid cancers (pathologic Stage T4 or N1) were treated with surgical resection. After surgery, 23...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2003-03, Vol.55 (4), p.1006-1012 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Kim, Tae-Hyun Yang, Dae-Sik Jung, Kwang-Yoon Kim, Chul-Yong Choi, Myung-Sun |
| description | To look for the possible efficacy of external beam irradiation (EBRT) for locally advanced papillary thyroid cancers
Between August 1981 and September 1997, 91 patients with locally advanced papillary thyroid cancers (pathologic Stage T4 or N1) were treated with surgical resection. After surgery, 23 patients received postoperative EBRT with or without ablative radioiodine therapy, and 68 patients were treated with ablative radioiodine therapy alone. The distribution of age, gender, and stage was comparable in both groups.
The overall survival rates at 7 years were not significantly different statistically between the two groups at 98.1% for the no-EBRT group and 90% for the EBRT group (
p = 0.506). The locoregional control rates at 5 years were significantly different (EBRT 95.2% and no EBRT 67.5%;
p = 0.0408). Analysis of the prognostic factors, age, gender, stage, and use of radioiodine ablative therapy, indicated these were not significant variables, except for EBRT.
Adjuvant postoperative EBRT did not affect overall survival, but significantly improved locoregional control in patients with locally advanced papillary thyroid cancer (Stage pT4 or lymph node involvement). |
| doi_str_mv | 10.1016/S0360-3016(02)04203-7 |
| format | Article |
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Between August 1981 and September 1997, 91 patients with locally advanced papillary thyroid cancers (pathologic Stage T4 or N1) were treated with surgical resection. After surgery, 23 patients received postoperative EBRT with or without ablative radioiodine therapy, and 68 patients were treated with ablative radioiodine therapy alone. The distribution of age, gender, and stage was comparable in both groups.
The overall survival rates at 7 years were not significantly different statistically between the two groups at 98.1% for the no-EBRT group and 90% for the EBRT group (
p = 0.506). The locoregional control rates at 5 years were significantly different (EBRT 95.2% and no EBRT 67.5%;
p = 0.0408). Analysis of the prognostic factors, age, gender, stage, and use of radioiodine ablative therapy, indicated these were not significant variables, except for EBRT.
Adjuvant postoperative EBRT did not affect overall survival, but significantly improved locoregional control in patients with locally advanced papillary thyroid cancer (Stage pT4 or lymph node involvement).</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/S0360-3016(02)04203-7</identifier><identifier>PMID: 12605980</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Analysis of Variance ; Biological and medical sciences ; Carcinoma, Papillary - radiotherapy ; Carcinoma, Papillary - secondary ; Carcinoma, Papillary - surgery ; Combined Modality Therapy ; External beam radiotherapy ; Female ; Humans ; Locoregional control ; Lymph Node Excision ; Male ; Medical sciences ; Middle Aged ; Neck ; Neoplasm Staging ; Papillary thyroid carcinoma ; Postoperative Complications ; Prognosis ; Survival Rate ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - radiotherapy ; Thyroid Neoplasms - surgery ; Thyroidectomy - methods</subject><ispartof>International journal of radiation oncology, biology, physics, 2003-03, Vol.55 (4), p.1006-1012</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-22ef1aad208ce2e67bc51ccac6b8ea143aff2a0a5f0143cca15859a59223a04b3</citedby><cites>FETCH-LOGICAL-c457t-22ef1aad208ce2e67bc51ccac6b8ea143aff2a0a5f0143cca15859a59223a04b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0360-3016(02)04203-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14590378$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12605980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Tae-Hyun</creatorcontrib><creatorcontrib>Yang, Dae-Sik</creatorcontrib><creatorcontrib>Jung, Kwang-Yoon</creatorcontrib><creatorcontrib>Kim, Chul-Yong</creatorcontrib><creatorcontrib>Choi, Myung-Sun</creatorcontrib><title>Value of external irradiation for locally advanced papillary thyroid cancer</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>To look for the possible efficacy of external beam irradiation (EBRT) for locally advanced papillary thyroid cancers
Between August 1981 and September 1997, 91 patients with locally advanced papillary thyroid cancers (pathologic Stage T4 or N1) were treated with surgical resection. After surgery, 23 patients received postoperative EBRT with or without ablative radioiodine therapy, and 68 patients were treated with ablative radioiodine therapy alone. The distribution of age, gender, and stage was comparable in both groups.
The overall survival rates at 7 years were not significantly different statistically between the two groups at 98.1% for the no-EBRT group and 90% for the EBRT group (
p = 0.506). The locoregional control rates at 5 years were significantly different (EBRT 95.2% and no EBRT 67.5%;
p = 0.0408). Analysis of the prognostic factors, age, gender, stage, and use of radioiodine ablative therapy, indicated these were not significant variables, except for EBRT.
Adjuvant postoperative EBRT did not affect overall survival, but significantly improved locoregional control in patients with locally advanced papillary thyroid cancer (Stage pT4 or lymph node involvement).</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Papillary - radiotherapy</subject><subject>Carcinoma, Papillary - secondary</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Combined Modality Therapy</subject><subject>External beam radiotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Locoregional control</subject><subject>Lymph Node Excision</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neck</subject><subject>Neoplasm Staging</subject><subject>Papillary thyroid carcinoma</subject><subject>Postoperative Complications</subject><subject>Prognosis</subject><subject>Survival Rate</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - radiotherapy</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy - methods</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFOGzEQhq2KqoTQR2jlC4geFsb2er17QghBqUDqoYB6sybesepqE6f2BpG3xyFROXLyWPPN-PfH2BcBpwJEc_YLVAOVKuUJyG9QS1CV-cAmojVdpbT-vccm_5F9dpDzXwAQwtSf2L6QDeiuhQm7fcRhRTx6Ts8jpQUOPKSEfcAxxAX3MfEhOhyGNcf-CReOer7EZRgGTGs-_lmnGHruNo10yD56HDJ93p1T9nB9dX95U939_P7j8uKucrU2YyUleYHYS2gdSWrMzGnhHLpm1hKKWqH3EgG1h3IpDaFb3aHupFQI9UxN2fF27zLFfyvKo52H7KhEWlBcZWsUaGOUKqDegi7FnBN5u0xhXoJbAXZj0b5atBtFFqR9tVjGp-zr7oHVbE7929ROWwGOdgDmIsen8v-Q37had6BMW7jzLUdFx1OgZLMLtJEYErnR9jG8E-UFab-PSw</recordid><startdate>20030315</startdate><enddate>20030315</enddate><creator>Kim, Tae-Hyun</creator><creator>Yang, Dae-Sik</creator><creator>Jung, Kwang-Yoon</creator><creator>Kim, Chul-Yong</creator><creator>Choi, Myung-Sun</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030315</creationdate><title>Value of external irradiation for locally advanced papillary thyroid cancer</title><author>Kim, Tae-Hyun ; Yang, Dae-Sik ; Jung, Kwang-Yoon ; Kim, Chul-Yong ; Choi, Myung-Sun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-22ef1aad208ce2e67bc51ccac6b8ea143aff2a0a5f0143cca15859a59223a04b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Papillary - radiotherapy</topic><topic>Carcinoma, Papillary - secondary</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Combined Modality Therapy</topic><topic>External beam radiotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>Locoregional control</topic><topic>Lymph Node Excision</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neck</topic><topic>Neoplasm Staging</topic><topic>Papillary thyroid carcinoma</topic><topic>Postoperative Complications</topic><topic>Prognosis</topic><topic>Survival Rate</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - radiotherapy</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Tae-Hyun</creatorcontrib><creatorcontrib>Yang, Dae-Sik</creatorcontrib><creatorcontrib>Jung, Kwang-Yoon</creatorcontrib><creatorcontrib>Kim, Chul-Yong</creatorcontrib><creatorcontrib>Choi, Myung-Sun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Tae-Hyun</au><au>Yang, Dae-Sik</au><au>Jung, Kwang-Yoon</au><au>Kim, Chul-Yong</au><au>Choi, Myung-Sun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of external irradiation for locally advanced papillary thyroid cancer</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2003-03-15</date><risdate>2003</risdate><volume>55</volume><issue>4</issue><spage>1006</spage><epage>1012</epage><pages>1006-1012</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>To look for the possible efficacy of external beam irradiation (EBRT) for locally advanced papillary thyroid cancers
Between August 1981 and September 1997, 91 patients with locally advanced papillary thyroid cancers (pathologic Stage T4 or N1) were treated with surgical resection. After surgery, 23 patients received postoperative EBRT with or without ablative radioiodine therapy, and 68 patients were treated with ablative radioiodine therapy alone. The distribution of age, gender, and stage was comparable in both groups.
The overall survival rates at 7 years were not significantly different statistically between the two groups at 98.1% for the no-EBRT group and 90% for the EBRT group (
p = 0.506). The locoregional control rates at 5 years were significantly different (EBRT 95.2% and no EBRT 67.5%;
p = 0.0408). Analysis of the prognostic factors, age, gender, stage, and use of radioiodine ablative therapy, indicated these were not significant variables, except for EBRT.
Adjuvant postoperative EBRT did not affect overall survival, but significantly improved locoregional control in patients with locally advanced papillary thyroid cancer (Stage pT4 or lymph node involvement).</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12605980</pmid><doi>10.1016/S0360-3016(02)04203-7</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 2003-03, Vol.55 (4), p.1006-1012 |
| issn | 0360-3016 1879-355X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Analysis of Variance Biological and medical sciences Carcinoma, Papillary - radiotherapy Carcinoma, Papillary - secondary Carcinoma, Papillary - surgery Combined Modality Therapy External beam radiotherapy Female Humans Locoregional control Lymph Node Excision Male Medical sciences Middle Aged Neck Neoplasm Staging Papillary thyroid carcinoma Postoperative Complications Prognosis Survival Rate Thyroid Neoplasms - pathology Thyroid Neoplasms - radiotherapy Thyroid Neoplasms - surgery Thyroidectomy - methods |
| title | Value of external irradiation for locally advanced papillary thyroid cancer |
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