Altered basal firing pattern and postactivation inhibition of locus coeruleus neurons in spontaneously hypertensive rats
We compared the spontaneous unit activity and inhibition of impulse activity following antidromic activation (postactivation inhibition, PAI) of locus coeruleus (LC) neurons in spontaneously hypertensive rats (SHR) with those of LC neurons in Wistar-Kyoto rats (WKY). Spontaneous spikes of the LC wer...
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| Veröffentlicht in: | Neuroscience letters 1992-03, Vol.137 (1), p.37-40 |
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| container_title | Neuroscience letters |
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| creator | Miyawaki, Takashi Kawamura, Hiroshi Mitsubayashi, Hiromi Usui, Wataru Yasugi, Tadao |
| description | We compared the spontaneous unit activity and inhibition of impulse activity following antidromic activation (postactivation inhibition, PAI) of locus coeruleus (LC) neurons in spontaneously hypertensive rats (SHR) with those of LC neurons in Wistar-Kyoto rats (WKY). Spontaneous spikes of the LC were analyzed by interspike time histograms. The basal unit activity and variation coefficient of the interspike interval were decreased in SHR. The duration of the PAI which was yielded by antidromic activation from the dorsal noradrenergic bundle was shortened in SHR. These findings suggest that SHR LC neurons possess an altered basal firing pattern and inhibitory mechanism. |
| doi_str_mv | 10.1016/0304-3940(92)90292-F |
| format | Article |
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Spontaneous spikes of the LC were analyzed by interspike time histograms. The basal unit activity and variation coefficient of the interspike interval were decreased in SHR. The duration of the PAI which was yielded by antidromic activation from the dorsal noradrenergic bundle was shortened in SHR. These findings suggest that SHR LC neurons possess an altered basal firing pattern and inhibitory mechanism.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(92)90292-F</identifier><identifier>PMID: 1625814</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Action Potentials ; Animals ; Antidromic stimulation ; Dorsal noradrenergic bundle ; Electroencephalography ; Heart Rate ; Hypertension - physiopathology ; Locus coeruleus ; Locus Coeruleus - physiology ; Male ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Single unit activity ; Spontaneously hypertensive rat</subject><ispartof>Neuroscience letters, 1992-03, Vol.137 (1), p.37-40</ispartof><rights>1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-7193e68f3da6e10c9b3ff7c083aa10705b680301bb1a0ebb796196a40b30ec1d3</citedby><cites>FETCH-LOGICAL-c303t-7193e68f3da6e10c9b3ff7c083aa10705b680301bb1a0ebb796196a40b30ec1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/030439409290292F$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1625814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyawaki, Takashi</creatorcontrib><creatorcontrib>Kawamura, Hiroshi</creatorcontrib><creatorcontrib>Mitsubayashi, Hiromi</creatorcontrib><creatorcontrib>Usui, Wataru</creatorcontrib><creatorcontrib>Yasugi, Tadao</creatorcontrib><title>Altered basal firing pattern and postactivation inhibition of locus coeruleus neurons in spontaneously hypertensive rats</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>We compared the spontaneous unit activity and inhibition of impulse activity following antidromic activation (postactivation inhibition, PAI) of locus coeruleus (LC) neurons in spontaneously hypertensive rats (SHR) with those of LC neurons in Wistar-Kyoto rats (WKY). Spontaneous spikes of the LC were analyzed by interspike time histograms. The basal unit activity and variation coefficient of the interspike interval were decreased in SHR. The duration of the PAI which was yielded by antidromic activation from the dorsal noradrenergic bundle was shortened in SHR. These findings suggest that SHR LC neurons possess an altered basal firing pattern and inhibitory mechanism.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>Antidromic stimulation</subject><subject>Dorsal noradrenergic bundle</subject><subject>Electroencephalography</subject><subject>Heart Rate</subject><subject>Hypertension - physiopathology</subject><subject>Locus coeruleus</subject><subject>Locus Coeruleus - physiology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Single unit activity</subject><subject>Spontaneously hypertensive rat</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EKkvhDUDyCcEhMLaTOL4gVRULSJW4wNmynQk1ytrBdlbdt8fbVHCD04xmvpmx_5-QlwzeMWD9exDQNkK18Ebxtwq44s3-EdmxQfJGKskfk90f5Cl5lvNPAOhY116QC9bzbmDtjtxdzQUTjtSabGY6-eTDD7qYUquBmjDSJeZiXPFHU3wM1Idbb_19Gic6R7dm6iKmdcaaBVxTDLlSNC8xFBMwrnk-0dvTgqlgyP6INJmSn5Mnk5kzvniIl-T7_uO368_NzddPX66vbhonQJRGMiWwHyYxmh4ZOGXFNEkHgzCGgYTO9kP9JbOWGUBrpeqZ6k0LVgA6NopL8nrbu6T4a8Vc9MFnh_O8PU1LAV0vW_FfsErG-DDwCrYb6FLMOeGkl-QPJp00A312Rp9l12fZteL63hm9r2OvHvav9oDj36HNitr_sPWxqnH0mHR2HoPD0Sd0RY_R__vAbxc2oBM</recordid><startdate>19920316</startdate><enddate>19920316</enddate><creator>Miyawaki, Takashi</creator><creator>Kawamura, Hiroshi</creator><creator>Mitsubayashi, Hiromi</creator><creator>Usui, Wataru</creator><creator>Yasugi, Tadao</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19920316</creationdate><title>Altered basal firing pattern and postactivation inhibition of locus coeruleus neurons in spontaneously hypertensive rats</title><author>Miyawaki, Takashi ; Kawamura, Hiroshi ; Mitsubayashi, Hiromi ; Usui, Wataru ; Yasugi, Tadao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-7193e68f3da6e10c9b3ff7c083aa10705b680301bb1a0ebb796196a40b30ec1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>Antidromic stimulation</topic><topic>Dorsal noradrenergic bundle</topic><topic>Electroencephalography</topic><topic>Heart Rate</topic><topic>Hypertension - physiopathology</topic><topic>Locus coeruleus</topic><topic>Locus Coeruleus - physiology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Single unit activity</topic><topic>Spontaneously hypertensive rat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyawaki, Takashi</creatorcontrib><creatorcontrib>Kawamura, Hiroshi</creatorcontrib><creatorcontrib>Mitsubayashi, Hiromi</creatorcontrib><creatorcontrib>Usui, Wataru</creatorcontrib><creatorcontrib>Yasugi, Tadao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyawaki, Takashi</au><au>Kawamura, Hiroshi</au><au>Mitsubayashi, Hiromi</au><au>Usui, Wataru</au><au>Yasugi, Tadao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered basal firing pattern and postactivation inhibition of locus coeruleus neurons in spontaneously hypertensive rats</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1992-03-16</date><risdate>1992</risdate><volume>137</volume><issue>1</issue><spage>37</spage><epage>40</epage><pages>37-40</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>We compared the spontaneous unit activity and inhibition of impulse activity following antidromic activation (postactivation inhibition, PAI) of locus coeruleus (LC) neurons in spontaneously hypertensive rats (SHR) with those of LC neurons in Wistar-Kyoto rats (WKY). Spontaneous spikes of the LC were analyzed by interspike time histograms. The basal unit activity and variation coefficient of the interspike interval were decreased in SHR. The duration of the PAI which was yielded by antidromic activation from the dorsal noradrenergic bundle was shortened in SHR. These findings suggest that SHR LC neurons possess an altered basal firing pattern and inhibitory mechanism.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>1625814</pmid><doi>10.1016/0304-3940(92)90292-F</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1992-03, Vol.137 (1), p.37-40 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Action Potentials Animals Antidromic stimulation Dorsal noradrenergic bundle Electroencephalography Heart Rate Hypertension - physiopathology Locus coeruleus Locus Coeruleus - physiology Male Rats Rats, Inbred SHR Rats, Inbred WKY Single unit activity Spontaneously hypertensive rat |
| title | Altered basal firing pattern and postactivation inhibition of locus coeruleus neurons in spontaneously hypertensive rats |
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