Dykellic acid inhibits drug-induced caspase-3-like protease activation

Dykellic acid is a novel microbial metabolite isolated from the broth of Westerdykella multispora F50733. Investigations on the molecular function of dykellic acid revealed that this compound partially inhibits calcium influx, resulting in a decrease in Ca 2+-dependent endonuclease activation and DN...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-03, Vol.302 (3), p.539-544
Hauptverfasser:	Lee, Sang-Han, Youk, Eun-Soo, Lee, Ho-Jae, Kho, Yung-Hee, Kim, Hwan Mook, Kim, Sung-Uk
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis inhibitor Blotting, Western Calcium - metabolism Camptothecin Camptothecin - metabolism Camptothecin - pharmacology Caspase 3 Caspase-3-like protease Caspases - metabolism Cell Line Cytochrome c Group - metabolism Cytosol - enzymology DNA Fragmentation Dose-Response Relationship, Drug Dykellic acid Endonucleases - metabolism Enzyme Activation Enzyme Precursors - metabolism HL-60 Cells Humans Inhibitor Jurkat Cells Microscopy, Electron, Scanning Models, Chemical Poly(ADP-ribose) Polymerases - metabolism Propionates - pharmacology Pyrones - pharmacology Spectrometry, Fluorescence Surface Plasmon Resonance Time Factors U937 Cells
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