Studies on the Constituents of Leonurus sibiricus L

Two new furanoditerpene-lactones, LS-1 (1) and LS-2 (2), were isolated along with four known furanoditerpene-lactones 3, 4, 5 and 6 from the aerial part of Leonurus sibiricus L. The structures of the new compounds were determined by spectroscopic means. Compounds 1—6 isolated here exhibited moderate...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2003, Vol.51(3), pp.341-342
Hauptverfasser:	Satoh, Mitsuru, Satoh, Yoshio, Isobe, Kimiaki, Fujimoto, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences cytotoxic activity furanoditerpene-lactone General pharmacology Labiatae Leonurus Leonurus sibiricus L Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Components, Aerial Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Tumor Cells, Cultured - drug effects
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Zusammenfassung:	Two new furanoditerpene-lactones, LS-1 (1) and LS-2 (2), were isolated along with four known furanoditerpene-lactones 3, 4, 5 and 6 from the aerial part of Leonurus sibiricus L. The structures of the new compounds were determined by spectroscopic means. Compounds 1—6 isolated here exhibited moderate cytotoxic activity (IC50=50—60 μg/ml) against leukemia cells (L 1210) in tissue culture.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.51.341