PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug 1 , 2 . The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet 3 , 4 . Its primary action is to decrease lipolysis in adipose...
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| Veröffentlicht in: | Nature medicine 2003-03, Vol.9 (3), p.352-355 |
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| creator | Tunaru, Sorin Kero, Jukka Schaub, Annette Wufka, Christian Blaukat, Andree Pfeffer, Klaus Offermanns, Stefan |
| description | Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug
1
,
2
. The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet
3
,
4
. Its primary action is to decrease lipolysis in adipose tissue by inhibiting hormone-sensitive triglyceride lipase
5
. This anti-lipolytic effect of nicotinic acid involves the inhibition of cyclic adenosine monophosphate (cAMP) accumulation in adipose tissue
6
through a G
i
-protein-mediated inhibition of adenylyl cyclase
7
,
8
,
9
. A G-protein-coupled receptor for nicotinic acid has been proposed in adipocytes
10
,
11
. Here, we show that the orphan G-protein-coupled receptor, 'protein upregulated in macrophages by interferon-γ' (mouse PUMA-G, human HM74)
12
,
13
, is highly expressed in adipose tissue and is a nicotinic acid receptor. Binding of nicotinic acid to PUMA-G or HM74 results in a G
i
-mediated decrease in cAMP levels. In mice lacking PUMA-G, the nicotinic acid–induced decrease in free fatty acid (FFA) and triglyceride plasma levels was abrogated, indicating that PUMA-G mediates the anti-lipolytic and lipid-lowering effects of nicotinic acid
in vivo
. The identification of the nicotinic acid receptor may be useful in the development of new drugs to treat dyslipidemia.
NOTE:
In the version of this article initially published online, the statements concerning equal author contribution and corresponding authors were incorrect. This mistake has been corrected for the HTML and print versions of the article. |
| doi_str_mv | 10.1038/nm824 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_73053607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A193899820</galeid><sourcerecordid>A193899820</sourcerecordid><originalsourceid>FETCH-LOGICAL-c573t-94a67fb419d5d7bf4375a7462f1f61af6dfc6f1fb9cfd25ba23ce66a99d391c43</originalsourceid><addsrcrecordid>eNqN0lFr3SAUAGAZG2vX9S-MMFihD-k0Ro2Pl7K1hZaObS17E2OOt5ZE79TA-u9rey_c3dGHETAaP4_meBA6JPiEYNp99lPXtK_QPmEtr4nAv16XPhZd3UnG99C7lO4xxhQz-RbtkYZxSgnbR7ffbq4W9Vml_VCdX4m20hGqCAZWOcRU2RAr70zIrrSVNm54lhMMTmeoXE5lnF09ulUYH3IxYC2Y_B69sXpMcLh5H6Cbr19-np7Xl9dnF6eLy9owQXMtW82F7VsiBzaI3rZUMC1a3lhiOdGWD9bw0u-lsUPDet1QA5xrKQcqiWnpATpax13F8HuGlNXkkoFx1B7CnJQoP0w5FgV-_Afehzn6cjbVNJQQ2nVP0eo1WuoRlPM25KjNEjxEPQYP1pXPCyJpJ2XX4OJPXvDlGWAqSXtpwfHOgmIy_MlLPaekLn58_397fbtrj_6yd6DHfJfCOGcXfNqFn9bQxJBSBKtW0U06PiiC1VMdqec6Ku7DJl1zXy57qzaFs90xlSm_hLjN526kR4zEypg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223113884</pqid></control><display><type>article</type><title>PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect</title><source>MEDLINE</source><source>Nature</source><source>SpringerLink Journals - AutoHoldings</source><creator>Tunaru, Sorin ; Kero, Jukka ; Schaub, Annette ; Wufka, Christian ; Blaukat, Andree ; Pfeffer, Klaus ; Offermanns, Stefan</creator><creatorcontrib>Tunaru, Sorin ; Kero, Jukka ; Schaub, Annette ; Wufka, Christian ; Blaukat, Andree ; Pfeffer, Klaus ; Offermanns, Stefan</creatorcontrib><description>Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug
1
,
2
. The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet
3
,
4
. Its primary action is to decrease lipolysis in adipose tissue by inhibiting hormone-sensitive triglyceride lipase
5
. This anti-lipolytic effect of nicotinic acid involves the inhibition of cyclic adenosine monophosphate (cAMP) accumulation in adipose tissue
6
through a G
i
-protein-mediated inhibition of adenylyl cyclase
7
,
8
,
9
. A G-protein-coupled receptor for nicotinic acid has been proposed in adipocytes
10
,
11
. Here, we show that the orphan G-protein-coupled receptor, 'protein upregulated in macrophages by interferon-γ' (mouse PUMA-G, human HM74)
12
,
13
, is highly expressed in adipose tissue and is a nicotinic acid receptor. Binding of nicotinic acid to PUMA-G or HM74 results in a G
i
-mediated decrease in cAMP levels. In mice lacking PUMA-G, the nicotinic acid–induced decrease in free fatty acid (FFA) and triglyceride plasma levels was abrogated, indicating that PUMA-G mediates the anti-lipolytic and lipid-lowering effects of nicotinic acid
in vivo
. The identification of the nicotinic acid receptor may be useful in the development of new drugs to treat dyslipidemia.
NOTE:
In the version of this article initially published online, the statements concerning equal author contribution and corresponding authors were incorrect. This mistake has been corrected for the HTML and print versions of the article.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm824</identifier><identifier>PMID: 12563315</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adipose tissue ; Adipose Tissue - metabolism ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cell Line ; Cloning, Molecular ; Fatty acids ; Fatty Acids, Nonesterified - metabolism ; Genes, Reporter ; GTP-Binding Proteins - metabolism ; Humans ; Hypolipidemic Agents - metabolism ; Infectious Diseases ; Metabolic Diseases ; Mice ; Mice, Knockout ; Molecular Medicine ; Molecular Sequence Data ; Neurosciences ; Niacin - metabolism ; Radioligand Assay ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; Receptors, G-Protein-Coupled ; Receptors, Nicotinic - genetics ; Receptors, Nicotinic - metabolism ; Tissue Distribution ; Triglycerides - metabolism</subject><ispartof>Nature medicine, 2003-03, Vol.9 (3), p.352-355</ispartof><rights>Springer Nature America, Inc. 2003</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-94a67fb419d5d7bf4375a7462f1f61af6dfc6f1fb9cfd25ba23ce66a99d391c43</citedby><cites>FETCH-LOGICAL-c573t-94a67fb419d5d7bf4375a7462f1f61af6dfc6f1fb9cfd25ba23ce66a99d391c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm824$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm824$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12563315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tunaru, Sorin</creatorcontrib><creatorcontrib>Kero, Jukka</creatorcontrib><creatorcontrib>Schaub, Annette</creatorcontrib><creatorcontrib>Wufka, Christian</creatorcontrib><creatorcontrib>Blaukat, Andree</creatorcontrib><creatorcontrib>Pfeffer, Klaus</creatorcontrib><creatorcontrib>Offermanns, Stefan</creatorcontrib><title>PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug
1
,
2
. The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet
3
,
4
. Its primary action is to decrease lipolysis in adipose tissue by inhibiting hormone-sensitive triglyceride lipase
5
. This anti-lipolytic effect of nicotinic acid involves the inhibition of cyclic adenosine monophosphate (cAMP) accumulation in adipose tissue
6
through a G
i
-protein-mediated inhibition of adenylyl cyclase
7
,
8
,
9
. A G-protein-coupled receptor for nicotinic acid has been proposed in adipocytes
10
,
11
. Here, we show that the orphan G-protein-coupled receptor, 'protein upregulated in macrophages by interferon-γ' (mouse PUMA-G, human HM74)
12
,
13
, is highly expressed in adipose tissue and is a nicotinic acid receptor. Binding of nicotinic acid to PUMA-G or HM74 results in a G
i
-mediated decrease in cAMP levels. In mice lacking PUMA-G, the nicotinic acid–induced decrease in free fatty acid (FFA) and triglyceride plasma levels was abrogated, indicating that PUMA-G mediates the anti-lipolytic and lipid-lowering effects of nicotinic acid
in vivo
. The identification of the nicotinic acid receptor may be useful in the development of new drugs to treat dyslipidemia.
NOTE:
In the version of this article initially published online, the statements concerning equal author contribution and corresponding authors were incorrect. This mistake has been corrected for the HTML and print versions of the article.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cell Line</subject><subject>Cloning, Molecular</subject><subject>Fatty acids</subject><subject>Fatty Acids, Nonesterified - metabolism</subject><subject>Genes, Reporter</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Humans</subject><subject>Hypolipidemic Agents - metabolism</subject><subject>Infectious Diseases</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Molecular Medicine</subject><subject>Molecular Sequence Data</subject><subject>Neurosciences</subject><subject>Niacin - metabolism</subject><subject>Radioligand Assay</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, G-Protein-Coupled</subject><subject>Receptors, Nicotinic - genetics</subject><subject>Receptors, Nicotinic - metabolism</subject><subject>Tissue Distribution</subject><subject>Triglycerides - metabolism</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0lFr3SAUAGAZG2vX9S-MMFihD-k0Ro2Pl7K1hZaObS17E2OOt5ZE79TA-u9rey_c3dGHETAaP4_meBA6JPiEYNp99lPXtK_QPmEtr4nAv16XPhZd3UnG99C7lO4xxhQz-RbtkYZxSgnbR7ffbq4W9Vml_VCdX4m20hGqCAZWOcRU2RAr70zIrrSVNm54lhMMTmeoXE5lnF09ulUYH3IxYC2Y_B69sXpMcLh5H6Cbr19-np7Xl9dnF6eLy9owQXMtW82F7VsiBzaI3rZUMC1a3lhiOdGWD9bw0u-lsUPDet1QA5xrKQcqiWnpATpax13F8HuGlNXkkoFx1B7CnJQoP0w5FgV-_Afehzn6cjbVNJQQ2nVP0eo1WuoRlPM25KjNEjxEPQYP1pXPCyJpJ2XX4OJPXvDlGWAqSXtpwfHOgmIy_MlLPaekLn58_397fbtrj_6yd6DHfJfCOGcXfNqFn9bQxJBSBKtW0U06PiiC1VMdqec6Ku7DJl1zXy57qzaFs90xlSm_hLjN526kR4zEypg</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Tunaru, Sorin</creator><creator>Kero, Jukka</creator><creator>Schaub, Annette</creator><creator>Wufka, Christian</creator><creator>Blaukat, Andree</creator><creator>Pfeffer, Klaus</creator><creator>Offermanns, Stefan</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030301</creationdate><title>PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect</title><author>Tunaru, Sorin ; Kero, Jukka ; Schaub, Annette ; Wufka, Christian ; Blaukat, Andree ; Pfeffer, Klaus ; Offermanns, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-94a67fb419d5d7bf4375a7462f1f61af6dfc6f1fb9cfd25ba23ce66a99d391c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cell Line</topic><topic>Cloning, Molecular</topic><topic>Fatty acids</topic><topic>Fatty Acids, Nonesterified - metabolism</topic><topic>Genes, Reporter</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Humans</topic><topic>Hypolipidemic Agents - metabolism</topic><topic>Infectious Diseases</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Molecular Medicine</topic><topic>Molecular Sequence Data</topic><topic>Neurosciences</topic><topic>Niacin - metabolism</topic><topic>Radioligand Assay</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, G-Protein-Coupled</topic><topic>Receptors, Nicotinic - genetics</topic><topic>Receptors, Nicotinic - metabolism</topic><topic>Tissue Distribution</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tunaru, Sorin</creatorcontrib><creatorcontrib>Kero, Jukka</creatorcontrib><creatorcontrib>Schaub, Annette</creatorcontrib><creatorcontrib>Wufka, Christian</creatorcontrib><creatorcontrib>Blaukat, Andree</creatorcontrib><creatorcontrib>Pfeffer, Klaus</creatorcontrib><creatorcontrib>Offermanns, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tunaru, Sorin</au><au>Kero, Jukka</au><au>Schaub, Annette</au><au>Wufka, Christian</au><au>Blaukat, Andree</au><au>Pfeffer, Klaus</au><au>Offermanns, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>9</volume><issue>3</issue><spage>352</spage><epage>355</epage><pages>352-355</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug
1
,
2
. The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet
3
,
4
. Its primary action is to decrease lipolysis in adipose tissue by inhibiting hormone-sensitive triglyceride lipase
5
. This anti-lipolytic effect of nicotinic acid involves the inhibition of cyclic adenosine monophosphate (cAMP) accumulation in adipose tissue
6
through a G
i
-protein-mediated inhibition of adenylyl cyclase
7
,
8
,
9
. A G-protein-coupled receptor for nicotinic acid has been proposed in adipocytes
10
,
11
. Here, we show that the orphan G-protein-coupled receptor, 'protein upregulated in macrophages by interferon-γ' (mouse PUMA-G, human HM74)
12
,
13
, is highly expressed in adipose tissue and is a nicotinic acid receptor. Binding of nicotinic acid to PUMA-G or HM74 results in a G
i
-mediated decrease in cAMP levels. In mice lacking PUMA-G, the nicotinic acid–induced decrease in free fatty acid (FFA) and triglyceride plasma levels was abrogated, indicating that PUMA-G mediates the anti-lipolytic and lipid-lowering effects of nicotinic acid
in vivo
. The identification of the nicotinic acid receptor may be useful in the development of new drugs to treat dyslipidemia.
NOTE:
In the version of this article initially published online, the statements concerning equal author contribution and corresponding authors were incorrect. This mistake has been corrected for the HTML and print versions of the article.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>12563315</pmid><doi>10.1038/nm824</doi><tpages>4</tpages></addata></record> |
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| ispartof | Nature medicine, 2003-03, Vol.9 (3), p.352-355 |
| issn | 1078-8956 1546-170X |
| language | eng |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Adipose tissue Adipose Tissue - metabolism Animals Biomedical and Life Sciences Biomedicine Cancer Research Cell Line Cloning, Molecular Fatty acids Fatty Acids, Nonesterified - metabolism Genes, Reporter GTP-Binding Proteins - metabolism Humans Hypolipidemic Agents - metabolism Infectious Diseases Metabolic Diseases Mice Mice, Knockout Molecular Medicine Molecular Sequence Data Neurosciences Niacin - metabolism Radioligand Assay Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism Tissue Distribution Triglycerides - metabolism |
| title | PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect |
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