Biphasic effects of leptin in porcine granulosa cells

The direct effects of recombinant porcine leptin on porcine granulosa cells were studied to test the hypothesis that leptin, acting through the nuclear transcription factor signal transducer and activator of transcription 3 (STAT-3), modulates sterol regulatory element-binding protein 1 (SREBP1) the...

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Veröffentlicht in:	Biology of reproduction 2003-03, Vol.68 (3), p.789-796
Hauptverfasser:	Ruiz-Cortes, Z.T, Martel-Kennes, Y, Gevry, N.Y, Downey, B.R, Palin, M.F, Murphy, B.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals binding proteins Biological and medical sciences CCAAT-Enhancer-Binding Proteins - metabolism Cells, Cultured cultured cells DNA-Binding Proteins - metabolism dose response Female Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation - drug effects granulosa cells Granulosa Cells - drug effects Granulosa Cells - metabolism Granulosa Cells - physiology hormonal regulation Hormone metabolism and regulation leptin Leptin - pharmacology Mammalian female genital system Phosphoproteins - genetics Phosphoproteins - metabolism phosphorylation Phosphorylation - drug effects progesterone Progesterone - metabolism promoter regions recombinant proteins Recombinant Proteins - pharmacology regulation regulatory proteins signal transducer and activator of transcription-3 STAT3 Transcription Factor steroidogenesis steroidogenic acute regulatory protein Sterol Regulatory Element Binding Protein 1 Swine temporal variation Trans-Activators - metabolism transcription (genetics) Transcription Factors Transcription, Genetic Transfection Vertebrates: reproduction
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