Evidence that estrogen receptor alpha, but not beta, mediates seasonal changes in the response of the ovine retrochiasmatic area to estradiol

In ewes, anestrus results from a reduction in LH pulsatility due to an increased sensitivity of the hypothalamic estradiol negative feedback system. Considerable evidence has implicated the A15 group of dopaminergic neurons in the retrochiasmatic area in this seasonally dependent estradiol effect. M...

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Veröffentlicht in:	Biology of reproduction 2003-03, Vol.68 (3), p.846-852
Hauptverfasser:	Hardy, S.L, Anderson, G.M, Valent, M, Connors, J.M, Goodman, R.L
Format:	Artikel
Sprache:	eng
Schlagworte:	anestrus Anestrus - drug effects Anestrus - physiology Animals antagonists Biological and medical sciences breeding season dopamine Dopamine Antagonists - pharmacology estradiol Estradiol - pharmacology Estrogen Receptor alpha Estrogen Receptor beta ewes Female Fundamental and applied biological sciences. Psychology genistein Genistein - pharmacology hormonal regulation hormone agonists hormone receptors hormone secretion Hormones and neuropeptides. Regulation hypothalamus Hypothalamus, Middle - drug effects Hypothalamus, Middle - physiology Hypothalamus. Hypophysis. Epiphysis. Urophysis luteinizing hormone Luteinizing Hormone - pharmacology ovariectomy physiological response pulsatile secretion Receptors, Estrogen - agonists Receptors, Estrogen - physiology seasonal variation Seasons sheep Sheep - physiology sulpiride Sulpiride - pharmacology Vertebrates: endocrinology
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