dup(12)(q13→qter) in two t(14;18)-negative follicular b-non-hodgkin's lymphomas
Two t(14;18)‐negative follicular B‐non‐Hodgkin's lymphomas with the same chromosomal abnormality, dup(12)(q13→qter), are presented. The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for th...
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| Veröffentlicht in: | Genes chromosomes & cancer 1992-06, Vol.4 (4), p.302-308 |
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| creator | Wlodarska, Iwona Mecucci, Cristina Vandenberghe, Elisabeth Hilliker, Carl Schoenmakers, Eric Stul, Michel Marynen, Peter Cassiman, Jean-Jacques Berghe, Herman Van Den De Wolf-Peeters, Chris Thomas, José |
| description | Two t(14;18)‐negative follicular B‐non‐Hodgkin's lymphomas with the same chromosomal abnormality, dup(12)(q13→qter), are presented. The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for the presence of the dup(12)(q13→qter) was found using fluorescence in situ hybridization. dup(12q) may be equivalent to the trisomy 12 originally described in B‐chronic lymphocytic leukemia. This chromosome anomaly has also been reported in B‐non‐Hodgkin's lymphomas, usually in association with other chromosome anomalies and a more aggressive tumor phenotype. Occurrence of dup(12q) in two histologically similar cases of follicular small cleaved‐cell lymphoma without a typical t(14;18), suggests that this karyotypic change may play a critical role in some cases of follicle center‐cell lymphomas. |
| doi_str_mv | 10.1002/gcc.2870040405 |
| format | Article |
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The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for the presence of the dup(12)(q13→qter) was found using fluorescence in situ hybridization. dup(12q) may be equivalent to the trisomy 12 originally described in B‐chronic lymphocytic leukemia. This chromosome anomaly has also been reported in B‐non‐Hodgkin's lymphomas, usually in association with other chromosome anomalies and a more aggressive tumor phenotype. 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Cancer</addtitle><description>Two t(14;18)‐negative follicular B‐non‐Hodgkin's lymphomas with the same chromosomal abnormality, dup(12)(q13→qter), are presented. The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for the presence of the dup(12)(q13→qter) was found using fluorescence in situ hybridization. dup(12q) may be equivalent to the trisomy 12 originally described in B‐chronic lymphocytic leukemia. This chromosome anomaly has also been reported in B‐non‐Hodgkin's lymphomas, usually in association with other chromosome anomalies and a more aggressive tumor phenotype. 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Mecucci, Cristina ; Vandenberghe, Elisabeth ; Hilliker, Carl ; Schoenmakers, Eric ; Stul, Michel ; Marynen, Peter ; Cassiman, Jean-Jacques ; Berghe, Herman Van Den ; De Wolf-Peeters, Chris ; Thomas, José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3245-60f381f6db55b187ba7f35d574ad97e5b3c06808af628420599af4e7419d58323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aged</topic><topic>B-non-Hodgkin's lymphoma</topic><topic>chromosome 12</topic><topic>chromosome 14</topic><topic>chromosome 18</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 12</topic><topic>Chromosomes, Human, Pair 14</topic><topic>Chromosomes, Human, Pair 18</topic><topic>DNA Probes - genetics</topic><topic>duplication</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Humans</topic><topic>Lymphoma, B-Cell - genetics</topic><topic>Lymphoma, Follicular - genetics</topic><topic>man</topic><topic>Nucleic Acid Hybridization</topic><topic>translocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wlodarska, Iwona</creatorcontrib><creatorcontrib>Mecucci, Cristina</creatorcontrib><creatorcontrib>Vandenberghe, Elisabeth</creatorcontrib><creatorcontrib>Hilliker, Carl</creatorcontrib><creatorcontrib>Schoenmakers, Eric</creatorcontrib><creatorcontrib>Stul, Michel</creatorcontrib><creatorcontrib>Marynen, Peter</creatorcontrib><creatorcontrib>Cassiman, Jean-Jacques</creatorcontrib><creatorcontrib>Berghe, Herman Van Den</creatorcontrib><creatorcontrib>De Wolf-Peeters, Chris</creatorcontrib><creatorcontrib>Thomas, José</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genes chromosomes & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wlodarska, Iwona</au><au>Mecucci, Cristina</au><au>Vandenberghe, Elisabeth</au><au>Hilliker, Carl</au><au>Schoenmakers, Eric</au><au>Stul, Michel</au><au>Marynen, Peter</au><au>Cassiman, Jean-Jacques</au><au>Berghe, Herman Van Den</au><au>De Wolf-Peeters, Chris</au><au>Thomas, José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>dup(12)(q13→qter) in two t(14;18)-negative follicular b-non-hodgkin's lymphomas</atitle><jtitle>Genes chromosomes & cancer</jtitle><addtitle>Genes Chromosom. Cancer</addtitle><date>1992-06</date><risdate>1992</risdate><volume>4</volume><issue>4</issue><spage>302</spage><epage>308</epage><pages>302-308</pages><issn>1045-2257</issn><eissn>1098-2264</eissn><abstract>Two t(14;18)‐negative follicular B‐non‐Hodgkin's lymphomas with the same chromosomal abnormality, dup(12)(q13→qter), are presented. The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for the presence of the dup(12)(q13→qter) was found using fluorescence in situ hybridization. dup(12q) may be equivalent to the trisomy 12 originally described in B‐chronic lymphocytic leukemia. This chromosome anomaly has also been reported in B‐non‐Hodgkin's lymphomas, usually in association with other chromosome anomalies and a more aggressive tumor phenotype. 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| ispartof | Genes chromosomes & cancer, 1992-06, Vol.4 (4), p.302-308 |
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| subjects | Aged B-non-Hodgkin's lymphoma chromosome 12 chromosome 14 chromosome 18 Chromosome Aberrations Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 DNA Probes - genetics duplication Female Fluorescence Humans Lymphoma, B-Cell - genetics Lymphoma, Follicular - genetics man Nucleic Acid Hybridization translocation |
| title | dup(12)(q13→qter) in two t(14;18)-negative follicular b-non-hodgkin's lymphomas |
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