Ethanol- and Fe(+2)-induced membrane lipid oxidation is not additive in developing chick brains
In order to study the effects of exogenous EtOH and/or Fe(+2) on membrane lipid peroxidation, exogenous EtOH, FeCl(2), FeCl(2) & EtOH, NaCl and NaCl & EtOH were injected into fertile chicken eggs. Controls were either shams or injected with saline. These injections were made at 0 days or 0-2...
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| Veröffentlicht in: | Comparative biochemistry and physiology. Toxicology & pharmacology 2003-02, Vol.134 (2), p.267-279 |
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| container_title | Comparative biochemistry and physiology. Toxicology & pharmacology |
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| creator | Miller, Jr, Robert R Coughlin, Daniel J Fraser-Thomson, Elisabeth Sabrina Noe, Elizabeth C Palenick, Amanda Voorhees, Emily B |
| description | In order to study the effects of exogenous EtOH and/or Fe(+2) on membrane lipid peroxidation, exogenous EtOH, FeCl(2), FeCl(2) & EtOH, NaCl and NaCl & EtOH were injected into fertile chicken eggs. Controls were either shams or injected with saline. These injections were made at 0 days or 0-2 days of development and tissue removed at stage 37 (11 days of development). Embryonic exposure to exogenous EtOH and/or Fe(+2) promoted decreased brain mass, decreased levels of brain membrane polyunsaturated fatty acids, elevated levels of brain lipid hydroperoxides, and elevated levels of Fe(+2) within embryonic brain and liver. These alterations were more severe in triple-injected embryos (E0-2/E11) as compared to single-injected embryos (E0/E11). While exogenous treatments of either EtOH and/or FeCl(2) promoted increased levels of endogenous brain Fe(+2), the effects were not additive. These observations are consistent with the hypothesis that embryonic exposure to exogenous EtOH and/or Fe(+2) promotes brain membrane lipid peroxidation. |
| doi_str_mv | 10.1016/S1532-0456(02)00278-8 |
| format | Article |
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Controls were either shams or injected with saline. These injections were made at 0 days or 0-2 days of development and tissue removed at stage 37 (11 days of development). Embryonic exposure to exogenous EtOH and/or Fe(+2) promoted decreased brain mass, decreased levels of brain membrane polyunsaturated fatty acids, elevated levels of brain lipid hydroperoxides, and elevated levels of Fe(+2) within embryonic brain and liver. These alterations were more severe in triple-injected embryos (E0-2/E11) as compared to single-injected embryos (E0/E11). While exogenous treatments of either EtOH and/or FeCl(2) promoted increased levels of endogenous brain Fe(+2), the effects were not additive. 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These observations are consistent with the hypothesis that embryonic exposure to exogenous EtOH and/or Fe(+2) promotes brain membrane lipid peroxidation.</description><subject>Animals</subject><subject>Brain - drug effects</subject><subject>Brain - embryology</subject><subject>Brain - metabolism</subject><subject>Chick Embryo</subject><subject>Drug Combinations</subject><subject>Ethanol - pharmacology</subject><subject>Fatty Acids, Unsaturated - analysis</subject><subject>Ferrous Compounds - pharmacology</subject><subject>Intracellular Membranes - chemistry</subject><subject>Intracellular Membranes - drug effects</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - embryology</subject><subject>Liver - metabolism</subject><subject>Organ Size - drug effects</subject><issn>1532-0456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFLwzAYxXNQ3Jz-CUpOsiHRL2matEcZmwoDD-q5pMlXF23T2rRD_3sHTk8PHr_3eDxCLjjccODq9pmniWAgUzUHsQAQOmPZEZn-2xNyGuM7AKSSqxMy4UIBqExPSbEatia0NaMmOLrG-bVYMB_caNHRBpuyNwFp7TvvaPvlnRl8G6iPNLQDNc75we-Q-kAd7rBuOx_eqN16-0H3SR_iGTmuTB3x_KAz8rpevSwf2Obp_nF5t2EdF2Jg3FYizyvjjNMSnNASHfDSiCRLbS5tia5CTASkKk1VjlpaLo1WSqDJKquTGbn67e369nPEOBSNjxbrej-_HWOhE5BZxmEPXh7AsWzQFV3vG9N_F3-XJD9nxWIf</recordid><startdate>200302</startdate><enddate>200302</enddate><creator>Miller, Jr, Robert R</creator><creator>Coughlin, Daniel J</creator><creator>Fraser-Thomson, Elisabeth Sabrina</creator><creator>Noe, Elizabeth C</creator><creator>Palenick, Amanda</creator><creator>Voorhees, Emily B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200302</creationdate><title>Ethanol- and Fe(+2)-induced membrane lipid oxidation is not additive in developing chick brains</title><author>Miller, Jr, Robert R ; Coughlin, Daniel J ; Fraser-Thomson, Elisabeth Sabrina ; Noe, Elizabeth C ; Palenick, Amanda ; Voorhees, Emily B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p122t-1cf299fadad740d274ed01ba2385c94cbedfee320565569e74c14a7662ea8fc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Brain - drug effects</topic><topic>Brain - embryology</topic><topic>Brain - metabolism</topic><topic>Chick Embryo</topic><topic>Drug Combinations</topic><topic>Ethanol - pharmacology</topic><topic>Fatty Acids, Unsaturated - analysis</topic><topic>Ferrous Compounds - pharmacology</topic><topic>Intracellular Membranes - chemistry</topic><topic>Intracellular Membranes - drug effects</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - embryology</topic><topic>Liver - metabolism</topic><topic>Organ Size - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Jr, Robert R</creatorcontrib><creatorcontrib>Coughlin, Daniel J</creatorcontrib><creatorcontrib>Fraser-Thomson, Elisabeth Sabrina</creatorcontrib><creatorcontrib>Noe, Elizabeth C</creatorcontrib><creatorcontrib>Palenick, Amanda</creatorcontrib><creatorcontrib>Voorhees, Emily B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. 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| ispartof | Comparative biochemistry and physiology. Toxicology & pharmacology, 2003-02, Vol.134 (2), p.267-279 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Brain - drug effects Brain - embryology Brain - metabolism Chick Embryo Drug Combinations Ethanol - pharmacology Fatty Acids, Unsaturated - analysis Ferrous Compounds - pharmacology Intracellular Membranes - chemistry Intracellular Membranes - drug effects Lipid Peroxidation - drug effects Liver - drug effects Liver - embryology Liver - metabolism Organ Size - drug effects |
| title | Ethanol- and Fe(+2)-induced membrane lipid oxidation is not additive in developing chick brains |
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