Radionuclide scintigraphy in the evaluation of gastro-oesophageal reflux in post-operative oesophageal atresia and tracheo-oesophageal fistula patients
Gastro-oesophageal reflux (GOR) is a major cause of morbidity in children who undergo surgical repair for oesophageal atresia with tracheo-oesophageal fistula (OA/TOF). We performed a retrospective analysis to determine the incidence of GOR on radionuclide scintigraphy in symptomatic and asymptomati...
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| Veröffentlicht in: | Nuclear medicine communications 2003-03, Vol.24 (3), p.317-320 |
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| creator | THOMAS, E J KUMAR, R DASAN, J B CHANDRASHEKAR, N AGARWALA, S TRIPATHI, M BAL, C S |
| description | Gastro-oesophageal reflux (GOR) is a major cause of morbidity in children who undergo surgical repair for oesophageal atresia with tracheo-oesophageal fistula (OA/TOF). We performed a retrospective analysis to determine the incidence of GOR on radionuclide scintigraphy in symptomatic and asymptomatic OA/TOF patients in the first post-operative year. A total of 124 patients (74 males, 50 females), with a mean age of 3.5 months (range, 20 days to 12 months), were studied. Of these 124 patients, 67 were symptomatic and 57 were asymptomatic. On radionuclide scintigraphy, 73 patients (48 symptomatic and 25 asymptomatic) had reflux. Of the 48 symptomatic patients with scintigraphic studies positive for reflux, 79.2% (38) had proximal reflux and 20.8% (10) had distal reflux, whereas, of the 57 asymptomatic patients, 48% (12) had proximal reflux and 52% (13) had distal reflux. There was a significantly higher incidence of GOR in symptomatic children than in asymptomatic children (P |
| doi_str_mv | 10.1097/00006231-200303000-00012 |
| format | Article |
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We performed a retrospective analysis to determine the incidence of GOR on radionuclide scintigraphy in symptomatic and asymptomatic OA/TOF patients in the first post-operative year. A total of 124 patients (74 males, 50 females), with a mean age of 3.5 months (range, 20 days to 12 months), were studied. Of these 124 patients, 67 were symptomatic and 57 were asymptomatic. On radionuclide scintigraphy, 73 patients (48 symptomatic and 25 asymptomatic) had reflux. Of the 48 symptomatic patients with scintigraphic studies positive for reflux, 79.2% (38) had proximal reflux and 20.8% (10) had distal reflux, whereas, of the 57 asymptomatic patients, 48% (12) had proximal reflux and 52% (13) had distal reflux. There was a significantly higher incidence of GOR in symptomatic children than in asymptomatic children (P<0.01). In particular, there was a significantly higher incidence of proximal GOR in symptomatic children than in asymptomatic children (P<0.001). In conclusion, the severity and incidence of GOR were significantly higher in symptomatic than asymptomatic OA/TOF patients in their first post-operative year. Scintigraphic evidence of proximal reflux correlates with the presence of symptomatic GOR.</description><identifier>ISSN: 0143-3636</identifier><identifier>EISSN: 1473-5628</identifier><identifier>DOI: 10.1097/00006231-200303000-00012</identifier><identifier>PMID: 12612473</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Biological and medical sciences ; Dilatation ; Esophageal Atresia - diagnostic imaging ; Esophageal Atresia - etiology ; Esophageal Atresia - therapy ; Follow-Up Studies ; Gastroesophageal Reflux - diagnostic imaging ; Gastroesophageal Reflux - surgery ; Humans ; Incidence ; Infant ; Infant, Newborn ; Medical sciences ; Postoperative Complications - diagnostic imaging ; Postoperative Complications - epidemiology ; Radionuclide Imaging ; Radiopharmaceuticals ; Technetium Tc 99m Sulfur Colloid ; Tracheoesophageal Fistula - diagnostic imaging ; Tracheoesophageal Fistula - etiology ; Tracheoesophageal Fistula - therapy</subject><ispartof>Nuclear medicine communications, 2003-03, Vol.24 (3), p.317-320</ispartof><rights>2003 Lippincott Williams & Wilkins, Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4562-bd447521b34b637c901f3c2e07e13e78f1c474a41eb2c28ba800647f22c55fa43</citedby><cites>FETCH-LOGICAL-c4562-bd447521b34b637c901f3c2e07e13e78f1c474a41eb2c28ba800647f22c55fa43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14642822$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12612473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THOMAS, E J</creatorcontrib><creatorcontrib>KUMAR, R</creatorcontrib><creatorcontrib>DASAN, J B</creatorcontrib><creatorcontrib>CHANDRASHEKAR, N</creatorcontrib><creatorcontrib>AGARWALA, S</creatorcontrib><creatorcontrib>TRIPATHI, M</creatorcontrib><creatorcontrib>BAL, C S</creatorcontrib><title>Radionuclide scintigraphy in the evaluation of gastro-oesophageal reflux in post-operative oesophageal atresia and tracheo-oesophageal fistula patients</title><title>Nuclear medicine communications</title><addtitle>Nucl Med Commun</addtitle><description>Gastro-oesophageal reflux (GOR) is a major cause of morbidity in children who undergo surgical repair for oesophageal atresia with tracheo-oesophageal fistula (OA/TOF). We performed a retrospective analysis to determine the incidence of GOR on radionuclide scintigraphy in symptomatic and asymptomatic OA/TOF patients in the first post-operative year. A total of 124 patients (74 males, 50 females), with a mean age of 3.5 months (range, 20 days to 12 months), were studied. Of these 124 patients, 67 were symptomatic and 57 were asymptomatic. On radionuclide scintigraphy, 73 patients (48 symptomatic and 25 asymptomatic) had reflux. Of the 48 symptomatic patients with scintigraphic studies positive for reflux, 79.2% (38) had proximal reflux and 20.8% (10) had distal reflux, whereas, of the 57 asymptomatic patients, 48% (12) had proximal reflux and 52% (13) had distal reflux. There was a significantly higher incidence of GOR in symptomatic children than in asymptomatic children (P<0.01). In particular, there was a significantly higher incidence of proximal GOR in symptomatic children than in asymptomatic children (P<0.001). In conclusion, the severity and incidence of GOR were significantly higher in symptomatic than asymptomatic OA/TOF patients in their first post-operative year. Scintigraphic evidence of proximal reflux correlates with the presence of symptomatic GOR.</description><subject>Biological and medical sciences</subject><subject>Dilatation</subject><subject>Esophageal Atresia - diagnostic imaging</subject><subject>Esophageal Atresia - etiology</subject><subject>Esophageal Atresia - therapy</subject><subject>Follow-Up Studies</subject><subject>Gastroesophageal Reflux - diagnostic imaging</subject><subject>Gastroesophageal Reflux - surgery</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Postoperative Complications - diagnostic imaging</subject><subject>Postoperative Complications - epidemiology</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Technetium Tc 99m Sulfur Colloid</subject><subject>Tracheoesophageal Fistula - diagnostic imaging</subject><subject>Tracheoesophageal Fistula - etiology</subject><subject>Tracheoesophageal Fistula - therapy</subject><issn>0143-3636</issn><issn>1473-5628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ks1u1TAQhS1ERS-FV0DewM7gv8TpElX8SZWQUFlbE2dyY_CNg-209El4XXy5F0oXtWXN5jtnNHNMCBX8teDn5g2vp5VKMMm5qpdzVp-Qj8hGaKNY08ruMdlwoRVTrWpPydOcv1WkU615Qk6FbIWs4Ib8-gKDj_Pqgh-QZufn4rcJlumW-pmWCSleQ1ihVIjGkW4hlxRZxByXCbYIgSYcw_pzjy8xFxYXTBW_Rvo_BCVh9kBhHmhJ4Ca8bzL6XNYAdKlSnEt-Rk5GCBmfH-sZ-fr-3dXFR3b5-cOni7eXzOk6JOsHrU0jRa903yrjzrkYlZPIDQqFphuF00aDFthLJ7seuro4bUYpXdOMoNUZeXXwXVL8sWIuduezwxBgxrhmaxTXbWN4BbsD6FLMuc5sl-R3kG6t4HYfiv0biv0Xiv0TSpW-OPZY-x0Od8JjChV4eQQgOwhjgtn5fMfpVstO7o30gbuJoWDK38N6g8lOdYFlsg99CvUbgPKnYQ</recordid><startdate>200303</startdate><enddate>200303</enddate><creator>THOMAS, E J</creator><creator>KUMAR, R</creator><creator>DASAN, J B</creator><creator>CHANDRASHEKAR, N</creator><creator>AGARWALA, S</creator><creator>TRIPATHI, M</creator><creator>BAL, C S</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200303</creationdate><title>Radionuclide scintigraphy in the evaluation of gastro-oesophageal reflux in post-operative oesophageal atresia and tracheo-oesophageal fistula patients</title><author>THOMAS, E J ; KUMAR, R ; DASAN, J B ; CHANDRASHEKAR, N ; AGARWALA, S ; TRIPATHI, M ; BAL, C S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4562-bd447521b34b637c901f3c2e07e13e78f1c474a41eb2c28ba800647f22c55fa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Dilatation</topic><topic>Esophageal Atresia - diagnostic imaging</topic><topic>Esophageal Atresia - etiology</topic><topic>Esophageal Atresia - therapy</topic><topic>Follow-Up Studies</topic><topic>Gastroesophageal Reflux - diagnostic imaging</topic><topic>Gastroesophageal Reflux - surgery</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>Postoperative Complications - diagnostic imaging</topic><topic>Postoperative Complications - epidemiology</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Technetium Tc 99m Sulfur Colloid</topic><topic>Tracheoesophageal Fistula - diagnostic imaging</topic><topic>Tracheoesophageal Fistula - etiology</topic><topic>Tracheoesophageal Fistula - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THOMAS, E J</creatorcontrib><creatorcontrib>KUMAR, R</creatorcontrib><creatorcontrib>DASAN, J B</creatorcontrib><creatorcontrib>CHANDRASHEKAR, N</creatorcontrib><creatorcontrib>AGARWALA, S</creatorcontrib><creatorcontrib>TRIPATHI, M</creatorcontrib><creatorcontrib>BAL, C S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THOMAS, E J</au><au>KUMAR, R</au><au>DASAN, J B</au><au>CHANDRASHEKAR, N</au><au>AGARWALA, S</au><au>TRIPATHI, M</au><au>BAL, C S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radionuclide scintigraphy in the evaluation of gastro-oesophageal reflux in post-operative oesophageal atresia and tracheo-oesophageal fistula patients</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>2003-03</date><risdate>2003</risdate><volume>24</volume><issue>3</issue><spage>317</spage><epage>320</epage><pages>317-320</pages><issn>0143-3636</issn><eissn>1473-5628</eissn><abstract>Gastro-oesophageal reflux (GOR) is a major cause of morbidity in children who undergo surgical repair for oesophageal atresia with tracheo-oesophageal fistula (OA/TOF). We performed a retrospective analysis to determine the incidence of GOR on radionuclide scintigraphy in symptomatic and asymptomatic OA/TOF patients in the first post-operative year. A total of 124 patients (74 males, 50 females), with a mean age of 3.5 months (range, 20 days to 12 months), were studied. Of these 124 patients, 67 were symptomatic and 57 were asymptomatic. On radionuclide scintigraphy, 73 patients (48 symptomatic and 25 asymptomatic) had reflux. Of the 48 symptomatic patients with scintigraphic studies positive for reflux, 79.2% (38) had proximal reflux and 20.8% (10) had distal reflux, whereas, of the 57 asymptomatic patients, 48% (12) had proximal reflux and 52% (13) had distal reflux. There was a significantly higher incidence of GOR in symptomatic children than in asymptomatic children (P<0.01). In particular, there was a significantly higher incidence of proximal GOR in symptomatic children than in asymptomatic children (P<0.001). 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| ispartof | Nuclear medicine communications, 2003-03, Vol.24 (3), p.317-320 |
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| subjects | Biological and medical sciences Dilatation Esophageal Atresia - diagnostic imaging Esophageal Atresia - etiology Esophageal Atresia - therapy Follow-Up Studies Gastroesophageal Reflux - diagnostic imaging Gastroesophageal Reflux - surgery Humans Incidence Infant Infant, Newborn Medical sciences Postoperative Complications - diagnostic imaging Postoperative Complications - epidemiology Radionuclide Imaging Radiopharmaceuticals Technetium Tc 99m Sulfur Colloid Tracheoesophageal Fistula - diagnostic imaging Tracheoesophageal Fistula - etiology Tracheoesophageal Fistula - therapy |
| title | Radionuclide scintigraphy in the evaluation of gastro-oesophageal reflux in post-operative oesophageal atresia and tracheo-oesophageal fistula patients |
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