Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase

The catalytic activity of phenylalanine hydroxylase (PAH, phenylalanine 4‐monooxygenase EC 1.14.16.1) is regulated by three main mechanisms, i.e. substrate (l‐phenylalanine, L‐Phe) activation, pterin cofactor inhibition and phosphorylation of a single serine (Ser16) residue. To address the molecular...

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