Testosterone inhibits the immunostimulant effect of thymosin fraction 5 on secondary immune response in mice

Testosterone inhibits the immunostimulant effect of thymosin fraction 5 on secondary immune response in mice

The purpose of the present investigation was to examine the in vivo influence of testosterone on the immune properties of a thymic factor (thymosin fraction 5, TF5) a partially purified thymic preparation in male Swiss IOPS/OF1 mice (5–10 weeks old). Testosterone administration (100 μg/ml) significa...

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Veröffentlicht in:International journal of immunopharmacology 1992-02, Vol.14 (2), p.263-268
Hauptverfasser: Catanzano-Troutaud, D., Ardail, D., Deschaux, P.A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibody Formation - drug effects
Biological and medical sciences
Cells, Cultured
Erythrocytes - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
Male
Mice
Modulation of the immune response (stimulation, suppression)
Sheep
Testosterone - pharmacology
Thymosin - analogs & derivatives
Thymosin - antagonists & inhibitors
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Zusammenfassung:The purpose of the present investigation was to examine the in vivo influence of testosterone on the immune properties of a thymic factor (thymosin fraction 5, TF5) a partially purified thymic preparation in male Swiss IOPS/OF1 mice (5–10 weeks old). Testosterone administration (100 μg/ml) significantly inhibited the enhanced anti-sheep red blood cell antibody response induced by TF5 (100 μg/ml); this inhibition was only observed on the secondary antibody response and not on the primary. These results suggest that gonadal steroids can affect the immune response by modulating the activity of thymic factors.
ISSN:0192-0561
1879-3495
DOI:10.1016/0192-0561(92)90038-M