THE SQUALESTATINS, NOVEL INHIBITORS OF SQUALENE SYNTHASE PRODUCED BY A SPECIES OF PHOMA: I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITY

During the screening of fungi for inhibitors of squalene synthase, Phoma sp. C2932 was found to produce three structurally related novel inhibitors. These compounds, designated the squalestatins, exhibited potent activity against both mammalian (rat liver) and fungal (Candida albicans) squalene synt...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1992/05/25, Vol.45(5), pp.639-647
Hauptverfasser:	DAWSON, MICHAEL J., FARTHING, JOHN E., MARSHALL, PETER S., MIDDLETON, ROBERT F., O'NEILL, MELANIE J., SHUTTLEWORTH, ALAN, STYLLI, CHARI, TAIT, R. MURRAY, TAYLOR, PAM M., WILDMAN, HOWARD G., BUSS, ANTONY D., LANGLEY, DAVID, HAYES, MICHAEL V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applied microbiology Biological and medical sciences Bridged Bicyclo Compounds - chemistry Bridged Bicyclo Compounds - isolation & purification Bridged Bicyclo Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors Fundamental and applied biological sciences. Psychology Fungi - drug effects Microbial Sensitivity Tests Microbiology Phoma Rats Tricarboxylic Acids - chemistry Tricarboxylic Acids - isolation & purification Tricarboxylic Acids - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	During the screening of fungi for inhibitors of squalene synthase, Phoma sp. C2932 was found to produce three structurally related novel inhibitors. These compounds, designated the squalestatins, exhibited potent activity against both mammalian (rat liver) and fungal (Candida albicans) squalene synthase. Furthermore, they also had broad spectrum in vitro antifungal activity.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.45.639