The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2 MR/LRP) is a large cell-surface glycoprotein consisting of a 515-kDa and an 85-kDa polypeptide; this receptor is thought to be responsible for the binding and endocytosis of activated alpha 2-macroglobulin a...

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Veröffentlicht in:	The Journal of biological chemistry 1992-06, Vol.267 (18), p.12420-12423
Hauptverfasser:	Kounnas, M Z, Morris, R E, Thompson, M R, FitzGerald, D J, Strickland, D K, Saelinger, C B
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases Amino Acid Sequence Animals Bacterial Toxins - metabolism Cells, Cultured Electrophoresis, Polyacrylamide Gel Exotoxins - metabolism Fibroblasts - cytology Humans Low Density Lipoprotein Receptor-Related Protein-1 Mice Molecular Sequence Data Pseudomonas aeruginosa - metabolism Pseudomonas aeruginosa Exotoxin A Receptors, Immunologic - metabolism Virulence Factors
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