Alterations in Janus Kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy

Experimental studies indicate that interleukin-6 (IL-6)-related cytokines, signaling via the shared receptor gp130, Janus kinases (JAKs), and signal transducers and activators of transcription (STATs), provide a critical cardiomyocyte survival pathway in vivo. Little is known about the activation of...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-02, Vol.107 (6), p.798-802
Hauptverfasser:	PODEWSKI, Edith K, HILFIKER-KLEINER, Denise, HILFIKER, Andres, MORAWIETZ, Henning, LICHTENBERG, Artur, WOLLERT, Kai C, DREXLER, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, CD - metabolism Biological and medical sciences Cardiology. Vascular system Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - pathology Carrier Proteins - metabolism Cell Survival Chronic Disease Cytokine Receptor gp130 Cytokines - metabolism DNA-Binding Proteins - metabolism Growth Inhibitors - metabolism Heart Heart Ventricles - metabolism Heart Ventricles - pathology Humans Immunohistochemistry Interleukin-6 - metabolism Intracellular Signaling Peptides and Proteins Janus Kinase 2 Leukemia Inhibitory Factor Leukemia Inhibitory Factor Receptor alpha Subunit Lymphokines - metabolism Medical sciences Membrane Glycoproteins - metabolism Myocarditis. Cardiomyopathies Myocardium - metabolism Myocardium - pathology Phosphorylation Protein-Tyrosine Kinases - metabolism Proteins - metabolism Proto-Oncogene Proteins Receptors, Cytokine - metabolism Receptors, OSM-LIF Repressor Proteins Signal Transduction STAT3 Transcription Factor Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins Trans-Activators - metabolism TYK2 Kinase
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