Overexpression of KIT in chromophobe renal cell carcinoma

We analysed gene-expression profiles in 15 surgical specimens of conventional, papillary, and chromophobe renal cell carcinomas (RCCs) using high-density oligonucleotide arrays. From about 12 000 genes targeted by the array, 67 were upregulated specifically in each histological type of RCC. The onco...

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Veröffentlicht in:	Oncogene 2003-02, Vol.22 (6), p.847-852
Hauptverfasser:	Yamazaki, Ken, Sakamoto, Michiie, Ohta, Tsutomu, Kanai, Yae, Ohki, Misao, Hirohashi, Setsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Biomarkers, Tumor Carcinoma, Renal Cell - genetics Cell Biology Cell membranes Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cytoplasm DNA microarrays Endothelial Growth Factors - genetics Endothelial Growth Factors - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genomics Growth factors Human Genetics Humans Immunohistochemistry Insulin-Like Growth Factor Binding Protein 3 - genetics Insulin-Like Growth Factor Binding Protein 3 - metabolism Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Internal Medicine Kidney cancer KIT protein Ligases - genetics Ligases - metabolism Lymphokines - genetics Lymphokines - metabolism Medicine Medicine & Public Health Molecular and cellular biology Oligonucleotides Oncology original-paper Pathology Proto-Oncogene Proteins c-kit - biosynthesis Proto-Oncogene Proteins c-kit - genetics Renal tubules Research centers Therapeutic targets Tumor Suppressor Proteins Tumorigenesis Tumors Ubiquitin-Protein Ligases Up-Regulation Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Von Hippel-Lindau Tumor Suppressor Protein
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